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Protein Overview: PHO23

General Information:
Name(s) found: PHO23 / YNL097C [SGD]
Description(s) found:
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  • gi|929856|emb|CAA90529.1| ORF2205 [Saccharomyces cerevisiae] [NCBI NR]
  • gi|6324232|ref|NP_014302.1| Probable component of the Rpd3 histone deacetylase complex, involved in transcriptional regulation of PHO5; C-terminus has similarity to human candidate tumor suppressor p33(ING1); Pho23p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|51013603|gb|AAT93095.1| YNL097C [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S58255 hypothetical protein YNL097c - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1730755|sp|P50947.1|PHO23_YEAST RecName: Full=Transcriptional regulatory protein PHO23 [NCBI NR]
  • gi|1302006|emb|CAA95973.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • (P50947) Hypothetical 37.0 kDa protein in RAS2-RPS7B intergenic region [Swiss-Prot]
  • Transcriptional regulatory protein PHO23 OS=Saccharomyces cerevisiae GN=PHO23 PE=1 SV=1 [Swiss-Prot]
  • PHO23 Protein involved in transcriptional regulation of PHO5 [mips]
  • Probable component of the Rpd3 histone deacetylase complex, involved in transcriptional regulation of PHO5; C-terminus has similarity to human candidate tumor suppressor p33(ING1) and its isoform ING3 [SGD]
  • PHO23, Chr XIV from 441363-442355, reverse complement [yeast_orfs2]
  • Chr XIV from 441363-442355, reverse complement [yeastorf3.fasta]
  • Chr XIV from 442355-441363, reverse complement [yeastorf5.fasta]
  • PHO23 SGDID:S0005041, Chr XIV from 442358-441366, reverse complement, Verified ORF [yeastflysequest.fasta]
  • Pho23p [Saccharomyces cerevisiae]gi|51013603|gb|AAT93095.1| YNL097C [Saccharomyces cerevisiae]gi|1302006|emb|CAA95973.1| unnamed protein product [Saccharomyces cerevisiae]gi|929856|emb|CAA90529.1| ORF2205 [Saccharomyces cerevisiae]gi|2131886|pir||S582 [nrdb_11152004_Chlamydomonas]
  • PHO23 SGDID:S000005041, Chr XIV from 442360-441368, reverse complement, Verified ORF, "Probable component of the Rpd3 histone deacetylase complex, involved in transcriptional regulation of PHO5; C-terminus has similarity to human candidate tumor suppresso [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • YNL097C [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Probable component of the Rpd3 histone deacetylase complex, involved in transcriptional regulation of PHO5; C-terminus has similarity to human candidate tumor suppressor p33(ING1); Pho23p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Transcriptional regulatory protein PHO23 [nr-271106-contam.fasta]
  • ORF2205 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • PHO23 SGDID:S000005041, Chr XIV from 442360-441368, reverse complement, Verified ORF, "Probable component of the Rpd3 histone deacetylase complex, involved in transcriptional regulation of PHO5; C-terminus has similarity to human candidate tumor suppressor p33(ING1) and its isoform ING3" [yeast-bovrabprots.fasta]
  • PHO23 SGDID:S000005041, Chr XIV from 442360-441368, reverse complement, Verified ORF, "Probable component of the Rpd3 histone deacetylase complex, involved in transcriptional regulation of PHO5; C-terminus has similarity to human candidate tumor suppressor p33(ING1)" [yeast-contam_custom.fasta]
  • [chemostatdb.fasta]
  • Transcriptional regulatory protein PHO23 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PHO23 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • PHO23 SGDID:S000005041, Chr XIV from 442358-441366, Genome Release 64-1-1, reverse complement, Verified ORF, "Probable component of the Rpd3 histone deacetylase complex, involved in transcriptional regulation of PHO5; affects termination of snoRNAs and cryptic unstable transcripts (CUTs); C-terminus has similarity to human candidate tumor suppressor p33(ING1) and its isoform ING3" [yeast-030211-contam.fasta]
  • PHO23 SGDID:S000005041, Chr XIV from 442358-441366, Genome Release 64-2-1, reverse complement, Verified ORF, "Component of the Rpd3L histone deacetylase complex; involved in transcriptional regulation of PHO5; affects termination of snoRNAs and cryptic unstable transcripts (CUTs); C-terminus has similarity to human candidate tumor suppressor p33(ING1) and its isoform ING3" [20141208_orf_trans.fasta]
  • TR6825|c0_g1_i1|g.4874 ORF TR6825|c0_g1_i1|g.4874 TR6825|c0_g1_i1|m.4874 type:complete len:331 (+) TR6825|c0_g1_i1:186-1178(+) [DBVPG6044_S_cerevisiae-Sep2015-contam.fasta]
  • YNL097C SGDID:S000005041, Chr XIV from 442358-441366, Genome Release 64-1-1, reverse complement, Verified ORF, "Probable component of the Rpd3 histone deacetylase complex, involved in transcriptional regulation of PHO5; affects termination of snoRNAs and cryptic unstable transcripts (CUTs); C-terminus has similarity to human candidate tumor suppressor p33(ING1) and its isoform ING3" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
  • asmbl_5661|g.4122 ORF asmbl_5661|g.4122 asmbl_5661|m.4122 type:complete len:331 (+) asmbl_5661:152-1144(+) [DBVPG6044_Trinity_v2_2_0_PASA_6May2016-contam.fasta]
  • ID=asmbl_5658|g.3404 ORF ID=asmbl_5658|g.3404 ID=asmbl_5658|m.3404 type:complete len:331 (+) ID=asmbl_5658:152-1144(+) [DBVPG6044_quiverGenomes_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 330 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    histone deacetylase complex [IDALink to PubMed article]
    Biological Process: chromatin modification [IMPLink to PubMed article][IPILink to PubMed article][ISSLink to PubMed article]
    histone deacetylation [IDALink to PubMed articleLink to PubMed article]
    Molecular Function: histone deacetylase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSPANLFPG LNDITDVLEE FPLATSRYLT LLHEIDAKCV HSMPNLNERI DKFLKKDFNK  60
   61 DHQTQVRLLN NINKIYEELM PSLEEKMHVS SIMLDNLDRL TSRLELAYEV AIKNTEIPRG 120
  121 LRLGVDNHPA MHLHHELMEK IESKSNSKSS QALKSESRRE AMAANRRQGE HYSASTHQQD 180
  181 DSKNDANYGG SRHESQDHTG NNTNSRKRAN AANTNNADPE TKKRKRRVAT TAVSPSTIST 240
  241 ATAVNNGRIG TSTASRGVSS VGNSNNSRIS RPKTNDYGEP LYCYCNQVAY GEMVGCDGAD 300
  301 CELEWFHLPC IGLETLPKGK WYCDDCKKKL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CTI6 DEP1 EAF3 PHO23 RCO1 RPD3 RXT2 RXT3 SAP30 SDS3 SIN3 UME1
    View Details Krogan NJ, et al. (2006) ASH1 COQ6 CTI6 DEP1 EAF3 GRX5 PHO23 RCO1 RPD3 RXT2 RXT3 SAP30 SAY1 SDS3 SIN3 UME1
    View Details Gavin AC, et al. (2002) ABF2 CKA1 CKA2 CKB1 CKB2 CTI6 DEP1 DOT6 EAF3 ECM16 HTA2 IOC3 ISW1 MED4 NHP10 NRD1 PHO23 RCO1 RPD3 RSC8 RXT2 RXT3 SAP30 SDS3 SIN3 STO1 TOP1 TUP1 UME1 UME6 VPS1
    View Details Qiu et al. (2008) HDA1 HDA3 HOS1 HST1 PHO23 RPD3 RXT2 SAP30 SDS3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PHO23 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..35]
    [81..207]    		 ORFEUS 7.33 Variant surface glycoprotein (N-terminal domain)
    2 View Details [36..80] ORFEUS 7.33 Variant surface glycoprotein (N-terminal domain)
    3 View Details [208..273] deduced N/A No confident structure predictions are available.
    4 View Details [274..330] PSI-BLAST 5.69897 Williams-Beuren syndrome transcription factor, WSTF

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • protein deacetylase activity
    		•  7.50578521120904 bayes_pls_golite062009
  • histone deacetylase activity
    		•  7.35162059871663 bayes_pls_golite062009
  • histone acetyltransferase activity
    		•  7.10262960897544 bayes_pls_golite062009
  • lysine N-acetyltransferase activity
    		•  7.10262960897544 bayes_pls_golite062009
  • deacetylase activity
    		•  6.55925777139018 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
    		•  5.24378850198774 bayes_pls_golite062009
  • N-acetyltransferase activity
    		•  5.0952093808777 bayes_pls_golite062009
    		• 4.75659254650148 bayes_pls_golite062009
  • N-acyltransferase activity
    		•  4.73470737654883 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
    		•  4.39452339322141 bayes_pls_golite062009
  • acetyltransferase activity
    		•  4.29938591960121 bayes_pls_golite062009
  • methylated histone residue binding
    		•  4.19057851212315 bayes_pls_golite062009
  • acyltransferase activity
    		•  3.59302841227183 bayes_pls_golite062009
    		• 3.57133019761926 bayes_pls_golite062009
  • transferase activity, transferring acyl groups other than amino-acyl groups
    		•  3.54892905221507 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  3.34035867339622 bayes_pls_golite062009
  • histone binding
    		•  3.01402804224903 bayes_pls_golite062009
  • binding
    		•  2.78627791259335 bayes_pls_golite062009
  • nucleosome binding
    		•  1.69494047037058 bayes_pls_golite062009
  • protein binding
    		•  1.6308789519356 bayes_pls_golite062009
  • chromatin binding
    		•  1.0360039180364 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.01735624308761 bayes_pls_golite062009
  • DNA binding
    		•  0.896491359501813 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.723245820583374 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.655033722565177 bayes_pls_golite062009
  • kinase activity
    		•  0.596989785523293 bayes_pls_golite062009
  • histone methyltransferase activity
    		•  0.476506467104495 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.465950484314184 bayes_pls_golite062009
  • protein kinase activity
    		•  0.405766438875014 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.327424740985033 bayes_pls_golite062009
  • transferase activity
    		•  0.245705939593188 bayes_pls_golite062009
  • histone methyltransferase activity (H3-K4 specific)
    		•  0.0490968711985191 bayes_pls_golite062009
  • histone acetyl-lysine binding
    		•  0.0410393640547611 bayes_pls_golite062009
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle