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Protein Overview: TOS4

General Information:
Name(s) found: TOS4 / YLR183C [SGD]
Description(s) found:
Found 31 descriptions.
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  • Forkhead Associated domain containing protein and putative transcription factor found associated with chromatin; target of SBF transcription factor; expression is periodic and peaks in G1; similar to PLM2 [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 489 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed articleLink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    Biological Process: regulation of transcription involved in G1/S-phase of mitotic cell cycle [IPILink to PubMed article]
    Molecular Function: transcription factor activity [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSQFPSSPY RTVDPYSPPN YKQQPNCPSS NYEKAGKTAS ESIGNFGKGD YPTPFPSSSI  60
   61 GRVSSPVRSN KVDAIPSSPA FPGQLAETSP KFSSKLSSPS RHTRVINAEL DPSKISTITV 120
  121 GRNSSQCDVA LCKNKFISRV HASITYLPQT NEVKIHCFSM NGLIVTYRKQ FDCYQLKDTM 180
  181 NNNNRAYRLV PRFSNEKCVK EIQDEGGFIN FTLEEGDTVY MTYYKGIMLD FRQVLLRISL 240
  241 KEKNSSSEPL RFEKKAEFES ESETKHMGSI RKHPLIFTDT SMDRPKKILK DSNKISIGSD 300
  301 SGVAERMLNH FLNSKSSPLS SVSSVDHEEQ TLRQDSLSSD KNPMTMKKPK LNKRVLPSKP 360
  361 KKSVKENLDE LSRRNIDVMH LQHILTNHLA FANVQQTPLF QLQQVNSQIS ELSRDELRSI 420
  421 LSDAKCVGVI YRHGKDAAGK PLDEEYFYDL ENDDDYERRN LVSSLKGGRT GLRSCRRTHK 480
  481 QYFWKKPAK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Gavin AC, et al. (2006) HTA1 TOS4
    View Details Gavin AC, et al. (2002) AAR2 BRR1 BUD31 CDC33 CEF1 CLF1 CSN12 CUS1 CWC2 CWC22 CWC23 DHH1 DIB1 ECM2 GCN2 HSH155 HTA1 IMG1 LEA1 LIN1 LSM1 LSM2 LSM4 LSM5 LSM6 LSM7 LUC7 MRP7 MRPL28 MRPL3 MRPL35 MRPL38 MRPL4 MRPL8 MRPS5 MSL1 MUD1 PAT1 PRP11 PRP18 PRP19 PRP21 PRP24 PRP28 PRP3 PRP31 PRP38 PRP39 PRP4 PRP40 PRP42 PRP43 PRP46 PRP6 PRP8 PRP9 RSE1 RVB2 SLU7 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNP1 SNT309 SNU114 SNU23 SNU56 SNU66 SNU71 SPP381 SPP382 SRB2 STO1 SYF1 TOS4 UTP21 YML6
    View Details Qiu et al. (2008) ATG27 FKH2 MNL1 NTC20 RIA1 RKI1 RPL11B RPL12B, RPL12A RPL13A RPL13B RPL14A RPL19B, RPL19A RPL20A RPL20B RPL23B, RPL23A RPL24A RPL24B RPL26A RPL26B RPL27B RPL29 RPL2A, RPL2B RPL33B RPL34A RPL35A, RPL35B RPL38 RPL40B, RPL40A RPL42B, RPL42A RPL5 RPL6A RPL6B RPL8B RPL9A RPL9B RPP2A RPS0B RPS10A RPS10B RPS16B, RPS16A RPS17A RPS17B RPS18B, RPS18A RPS1A RPS1B RPS22A RPS23B, RPS23A RPS25B RPS26B RPS29A RPS4B, RPS4A RPS6A, RPS6B RPS7B RPS8B, RPS8A TOS4 UTP6 VMA6 YPL199C

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data TOS4 Sundin BA, et al. (2004)
    View Data TOS4 Sundin BA, et al. (2004)
    View Data TOS4 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..183] ab initio 7.02 No description for 1g3gA was found.
    2 View Details [184..266] deduced N/A No confident structure predictions are available.
    3 View Details [267..489] MSA 1.004997 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle