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Protein Overview: URB2

General Information:
Name(s) found: URB2 / YJR041C [SGD]
Description(s) found:
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  • gi|6322501|ref|NP_012575.1| Nucleolar protein required for normal metabolism of the rRNA primary transcript, proposed to be involved in ribosome biogenesis; Urb2p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1352879|sp|P47108.1|URB2_YEAST RecName: Full=Nucleolar pre-ribosomal-associated protein 2; AltName: Full=Unhealthy ribosome biogenesis protein 2 [NCBI NR]
  • gi|1197069|gb|AAA88743.1| ORF; putative [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S57060 probable membrane protein YJR041c - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1015693|emb|CAA89568.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • (P47108) Hypothetical 135.1 kDa protein in GEF1-NUP85 intergenic region [Swiss-Prot]
  • Nucleolar pre-ribosomal-associated protein 2 OS=Saccharomyces cerevisiae GN=URB2 PE=1 SV=1 [Swiss-Prot]
  • URB2 Nucleolar protein required for normal metabolism of the rRNA primary transcript [mips]
  • Nucleolar protein required for normal metabolism of the rRNA primary transcript, proposed to be involved in ribosome biogenesis [SGD]
  • YJR041C, Chr X from 509931-513455, reverse complement [yeast_orfs2]
  • Chr X from 509931-513455, reverse complement [yeastorf3.fasta]
  • Chr X from 509932-513456, reverse complement [yeastorf4.fasta]
  • Chr X from 513457-509933, reverse complement [yeastorf5.fasta]
  • URB2 SGDID:S0003802, Chr X from 513677-510153, reverse complement, Uncharacterized ORF [yeastflysequest.fasta]
  • URB2 SGDID:S0003802, Chr X from 513677-510153, reverse complement, Verified ORF [10112005cervSGD.fasta]
  • Nucleolar protein required for normal metabolism of the rRNA primary transcript, proposed to be involved in ribosome biogenesis [Saccharomyces cerevisiae]gi|1015693|emb|CAA89568.1| unnamed protein product [Saccharomyces cerevisiae]gi|1078264|pir||S57060 [nrdb_11152004_Chlamydomonas]
  • URB2 SGDID:S000003802, Chr X from 513677-510153, reverse complement, Verified ORF, "Nucleolar protein required for normal metabolism of the rRNA primary transcript, proposed to be involved in ribosome biogenesis" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • URB2 SGDID:S000003802, Chr X from 513756-510232, reverse complement, Verified ORF, "Nucleolar protein required for normal metabolism of the rRNA primary transcript, proposed to be involved in ribosome biogenesis" [yeast-contam.fasta]
  • URB2 SGDID:S000003802, Chr X from 513755-510231, reverse complement, Verified ORF, "Nucleolar protein required for normal metabolism of the rRNA primary transcript, proposed to be involved in ribosome biogenesis" [yeast-200209-contam.fasta]
  • Nucleolar protein required for normal metabolism of the rRNA primary transcript, proposed to be involved in ribosome biogenesis; Urb2p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Hypothetical 135.1 kDa protein in GEF1-NUP85 intergenic region [nr-271106-contam.fasta]
  • ORF; putative [nr-271106-contam.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • Nucleolar pre-ribosomal-associated protein 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=URB2 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • URB2 SGDID:S000003802, Chr X from 513763-510239, Genome Release 64-1-1, reverse complement, Verified ORF, "Nucleolar protein required for normal metabolism of the rRNA primary transcript, proposed to be involved in ribosome biogenesis" [yeast-030211-contam.fasta]
  • URB2 SGDID:S000003802, Chr X from 513763-510239, Genome Release 64-2-1, reverse complement, Verified ORF, "Protein required for normal metabolism of the rRNA primary transcript; nucleolar protein; proposed to be involved in ribosome biogenesis" [20141208_orf_trans.fasta]
  • YJR041C SGDID:S000003802, Chr X from 513763-510239, Genome Release 64-1-1, reverse complement, Verified ORF, "Nucleolar protein required for normal metabolism of the rRNA primary transcript, proposed to be involved in ribosome biogenesis" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 1174 amino acids

    Gene Ontology:
    Cellular Component: nucleolus [IDALink to PubMed articleLink to PubMed article]
    Biological Process: rRNA metabolic process [IMPLink to PubMed article]
    ribosome biogenesis [IPILink to PubMed article][RCALink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGDLTEELSI PDNAQDLSKL LRSTSTKPHQ IAEIVSKFDK LETYFPKKEI FVLDLLIDRL  60
   61 NNGNLDDFKT SEHTWIIFTR LLDAINDPIS IKKLLKKLKT VPVMIRTFFL WPKDKLLTRS 120
  121 VSFIKAFFAI NDYLIVNFSV EESFQLLEHA INGLSSCPTT DFALSYLQDA CNLTHVDNIT 180
  181 TTDNKIATCY CKHMLLPSLR YFAQTKNSAS SNQSFIRLSH FMGKFLLQPR IDYMKLNKKF 240
  241 VQENASEITD DMAYYYFATF VTFLSKDNFA QLEVIFTILG AKKPSLECRF LNLLSESKKT 300
  301 VSQEFLEALL LEMLASTDES GVLSLIPIIL KLDIEVAIKH IFRLLELIQL ENLNDPLFSS 360
  361 HIWDLIIQSH ANARELSDFF AKINEYCSRK GPDSYFLINH PAYVKSITKQ LFTLSSLQWK 420
  421 NLLQALLDQV NHDSTNRVPL YLIRICLEGL SEGASRATLD EVKPILSQVF TLESFNNSLQ 480
  481 WDLKYHIMEV YDDIVPAEEL EKIDYVLSSN IFDTTSADVE ELFFYCFKLR EYISFDLSDA 540
  541 KKKFMRHFEI LDEERKSNLS YSVVSKFATL VNNNFTREQI SSLIDSLLLN STNLSSLLKN 600
  601 DDIFEETNIT YALINKLASS YHQTFALEAL IQIPIQCINK NVRVALINNL TCESFCLDSA 660
  661 TRECLLHLLS SPTFKSNIET NFYELCEKTI MSPEMAISET GDEKKEIEDK ISIFEKVWTN 720
  721 HLSQAKEPVS EKFLESGYDI VKQSMSLSNG DSKLIIAGFT IAKFLKPDNK HRDIQGMAIS 780
  781 YAVKILENYS ENFESETIPL FRISMSTLYK IITTGQGDIS KHKSRILDIF SKIMLRYHSK 840
  841 KVYHAPEEQE MFLVHSLLTE NKLEYIFAEY LNIEHTDKCD SALGFCLEES LKQGPDAFNR 900
  901 LLWNSAKSFS TISQPCAEKF VRVFIIMSKR IARDNNLGHH LFVIALLEAY TYCDIEKFGY 960
  961 KSYLLLFNAI KEFLVSKPWL FSQYCIEMLL PFCLKTLAFI VNHESTDEIN EGFINIIEVI1020
 1021 DHMLLVHRFK FSNRHHLFNS VLCQILEIIA IHDGTLCANS ADAVARLITN YCEPYNVSNA1080
 1081 QNGQKNNLSS KISLIKQSIR KNVLVVLTKY IQLSITTQFS LNIKKSLQPG IHAIFDILSQ1140
 1141 NELNQLNAFL DTPGKQYFKA LYLQYKKVGK WRED

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) URB1 URB2
    View Details Krogan NJ, et al. (2006) CBC2 KAP95 NUP1 NUP2 NUP60 OGG1 PCT1 RAD53 SRP1 STO1 ULP1 URB2 YRA2
    View Details Gavin AC, et al. (2006) NOP8 URB1 URB2
    View Details Ho Y, et al. (2002) CBF5 CBP2 CCM1 CDC33 CIC1 DBP7 DRS1 ENP2 ERB1 GBP2 HAS1 HMO1 HTB2 IMD1 IMD3 ISA1 KRE33 KRI1 KRR1 MGM101 MSS116 NOC2 NOP12 NOP6 NPL3 PET127 POL5 PRP43 PUF6 PWP1 RLI1 RPF2 RRP12 RRP5 TIF4631 TIF6 TRA1 TSR1 URB1 URB2 UTP10 UTP20 YPP1 YRA1 YTM1
    View Details Qiu et al. (2008) DHR2 GAR1 MAK5 URB2 UTP6 UTP8 UTP9

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run SLI15 No Comments Cheeseman IM, et al. (2002)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run MLP2 #31 Asynchronous Prep (Protease cleavage) Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen RBG1 URB2 1 Unpublished Fields Lab Data
    View Screen SPT21 URB2 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data URB2 and NOP56 Huh WK, et al. (2003)
    View Data URB2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..267] Pcons 1.6 Constant regulatory domain of protein phosphatase 2a, pr65alpha
    2 View Details [268..336] Pcons 1.6 Constant regulatory domain of protein phosphatase 2a, pr65alpha
    3 View Details [337..509] Pcons 1.6 Constant regulatory domain of protein phosphatase 2a, pr65alpha
    4 View Details [510..748] Pcons 1.6 Constant regulatory domain of protein phosphatase 2a, pr65alpha
    5 View Details [749..1003] deduced N/A No confident structure predictions are available.
    6 View Details [1004..1174] MSA 1.003931 View MSA. Confident ab initio structure predictions are available.
    7 View Details [767..977] deduced N/A No confident structure predictions are available.
    8 View Details [978..1174] MSA 4.016994 View MSA. Confident ab initio structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.92

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle