Protein Overview: NAB2

General Information:
Name(s) found:	NAB2 / YGL122C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6321316\|ref\|NP_011393.1\| Nuclear polyadenylated RNA-binding protein; autoregulates mRNA levels; related to human hnRNPs; has nuclear localization signal sequence that binds to Kap104p; required for poly(A) tail length control and nuclear mRNA export; N [NCBI NR] pir\|\|B48058 RNA-binding protein NAB2 - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|51830329\|gb\|AAU09727.1\| YGL122C [Saccharomyces cerevisiae] [NCBI NR] gi\|417337\|sp\|P32505.1\|NAB2_YEAST RecName: Full=Nuclear polyadenylated RNA-binding protein NAB2 [NCBI NR] gi\|295629\|gb\|AAA34819.1\| RNA-binding protein [NCBI NR] gi\|1322681\|emb\|CAA96830.1\| NAB2 [Saccharomyces cerevisiae] [NCBI NR] Nuclear polyadenylated RNA-binding protein NAB2 OS=Saccharomyces cerevisiae GN=NAB2 PE=1 SV=1 [Swiss-Prot] NAB2 Nuclear poly(A)-binding protein [mips] Nuclear polyadenylated RNA-binding protein required for nuclear mRNA export and poly(A) tail length control; binds nuclear pore protein Mlp1p; autoregulates mRNA levels; related to human hnRNPs; nuclear localization sequence binds Kap104p [SGD] NAB2, Chr VII from 278947-280524, reverse complement [yeast_orfs2] Chr VII from 278947-280524, reverse complement [yeastorf3.fasta] Chr VII from 278950-280527, reverse complement [yeastorf4.fasta] Chr VII from 280527-278950, reverse complement [yeastorf5.fasta] (P32505) Nuclear polyadenylated RNA-binding protein NAB2 [4932.FASTACCERV.txt] NAB2 SGDID:S0003090, Chr VII from 280527-278950, reverse complement, Verified ORF [yeastflysequest.fasta] NAB2 SGDID:S0003090, Chr VII from 280529-278952, reverse complement, Verified ORF [10112005cervSGD.fasta] Nab2p [Saccharomyces cerevisiae]gi\|51830329\|gb\|AAU09727.1\| YGL122C [Saccharomyces cerevisiae]gi\|1322681\|emb\|CAA96830.1\| NAB2 [Saccharomyces cerevisiae]gi\|539349\|pir\|\|B48058 RNA-binding protein NAB2 - yeast (Saccharomyces cerevisiae)gi\|417337\|sp\|P32505 [nrdb_11152004_Chlamydomonas] NAB2 SGDID:S000003090, Chr VII from 280529-278952, reverse complement, Verified ORF, "Nuclear polyadenylated RNA-binding protein; autoregulates mRNA levels; related to human hnRNPs; has nuclear localization signal sequence that binds to Kap104p; required [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] NAB2 SGDID:S000003090, Chr VII from 280529-278952, reverse complement, Verified ORF, "Nuclear polyadenylated RNA-binding protein required for nuclear mRNA export and poly(A) tail length control; binds nuclear pore protein Mlp1p; autoregulates mRNA levels; [yeast-200209-contam.fasta] Nuclear polyadenylated RNA-binding protein; autoregulates mRNA levels; related to human hnRNPs; has nuclear localization signal sequence that binds to Kap104p; required for poly(A) tail length control and nuclear mRNA export; Nab2p [Saccharomyces cerevisi [nr-271106-contam.fasta] RNA-binding protein [nr-271106-contam.fasta] Nuclear polyadenylated RNA-binding protein NAB2 [nr-271106-contam.fasta] NAB2 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] YGL122C [Saccharomyces cerevisiae] [nr-271106-contam.fasta] NAB2 SGDID:S000003090, Chr VII from 280529-278952, reverse complement, Verified ORF, "Nuclear polyadenylated RNA-binding protein required for nuclear mRNA export and poly(A) tail length control; binds nuclear pore protein Mlp1p; autoregulates mRNA levels; related to human hnRNPs; nuclear localization sequence binds Kap104p" [yeast-bovrabprots.fasta] NAB2 SGDID:S000003090, Chr VII from 280529-278952, reverse complement, Verified ORF, "Nuclear polyadenylated RNA-binding protein; autoregulates mRNA levels; related to human hnRNPs; has nuclear localization signal sequence that binds to Kap104p; required for poly(A) tail length control and nuclear mRNA export" [yeast-contam_custom.fasta] [chemostatdb.fasta] Nuclear polyadenylated RNA-binding protein NAB2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NAB2 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] NAB2 SGDID:S000003090, Chr VII from 280523-278946, Genome Release 64-1-1, reverse complement, Verified ORF, "Nuclear polyadenylated RNA-binding protein required for nuclear mRNA export and poly(A) tail length control; binds nuclear pore protein Mlp1p; autoregulates mRNA levels; related to human hnRNPs; nuclear localization sequence binds Kap104p" [yeast-030211-contam.fasta] NAB2 SGDID:S000003090, Chr VII from 280523-278946, Genome Release 64-2-1, reverse complement, Verified ORF, "Nuclear polyadenylated RNA-binding protein; required for nuclear mRNA export and poly(A) tail length control; binds nuclear pore protein Mlp1p; involved in forming export-competent mRNPs in the nucleus; autoregulates mRNA levels; related to human hnRNPs; nuclear localization sequence binds Kap104p; protein abundance increases in response to DNA replication stress" [20141208_orf_trans.fasta] YGL122C SGDID:S000003090, Chr VII from 280523-278946, Genome Release 64-1-1, reverse complement, Verified ORF, "Nuclear polyadenylated RNA-binding protein required for nuclear mRNA export and poly(A) tail length control; binds nuclear pore protein Mlp1p; autoregulates mRNA levels; related to human hnRNPs; nuclear localization sequence binds Kap104p" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	525 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA ][TAS] cytoplasm [TAS]
Biological Process:	mRNA polyadenylation [IDA] poly(A)+ mRNA export from nucleus [IMP]
Molecular Function:	poly(A) RNA binding [TAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQEQYTENL KVIVAEKLAG IPNFNEDIKY VAEYIVLLIV NGGTVESVVD ELASLFDSVS  60
   61 RDTLANVVQT AFFALEALQQ GESAENIVSK IRMMNAQSLG QSDIAQQQQQ QQQQQQPDIA 120
  121 QQQPQQQPQQ QPQQQPQQQP QQQPQQQPQQ QPQQQPQLQP LQPQLGTQNA MQTDAPATPS 180
  181 PISAFSGVVN AAAPPQFAPV DNSQRFTQRG GGAVGKNRRG GRGGNRGGRN NNSTRFNPLA 240
  241 KALGMAGESN MNFTPTKKEG RCRLFPHCPL GRSCPHAHPT KVCNEYPNCP KPPGTCEFLH 300
  301 PNEDEELMKE MERTREEFQK RKADLLAAKR KPVQTGIVLC KFGALCSNPS CPFGHPTPAN 360
  361 EDAKVIDLMW CDKNLTCDNP ECRKAHSSLS KIKEVKPISQ KKAAPPPVEK SLEQCKFGTH 420
  421 CTNKRCKYRH ARSHIMCREG ANCTRIDCLF GHPINEDCRF GVNCKNIYCL FRHPPGRVLP 480
  481 EKKGAAPNSN VPTNERPFAL PENAIIENAP PQTSFTHQEQ DTEMN

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		ENP1 HRP1 KAP104 MRT4 NAB2 YNL035C
View Details	Gavin AC, et al. (2002)		BMH1 BMH2 CLU1 CRM1 ECM29 FKS1 GCN1 GEA2 GFA1 HRP1 KAP104 KAP123 LCB1 LCB2 LYS12 MIR1 NAB2 SAM1 SAM2 YHR020W
View Details	Ho Y, et al. (2002)		ADH4 ADR1 ARC1 AYR1 BGL2 CBP6 DIM1 DPS1 ENP1 FAA1 GAR1 GSP1 GSP2 HEM15 HRP1 HTA2 KAP104 KTR3 MRT4 NAB2 NDE1 OAC1 PAA1 PET10 PET9 PGM2 PSD1 RPT4 RTN2 SAC1 TFG2 VMA8 YDL063C YHM2 YNL035C YRB1
View Details	Qiu et al. (2008)		NAB2 NPL3

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	MLP2	#12 Mitotic Prep1-TiO2 Flowthrough	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

	PROTEIN(S)	PUBLICATION
View Data	NAB2	Huh WK, et al. (2003)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..237]	ORFEUS	14.87	RBP1
2	View Details	[238..525]	ORFEUS	9.66	Hybrid domain of integrin beta; Integrin beta A domain; Integrin beta tail domain; Integrin beta EGF-like domains

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: NAB2

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: