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Protein Overview: FRS2

General Information:
Name(s) found: FRS2 / YFL022C [SGD]
Description(s) found:
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  • gi|836732|dbj|BAA09216.1| cytoplasmic phenylalanyl-tRNA synthetase beta chain [Saccharomyces cerevisiae] [NCBI NR]
  • pir||YFBYAC phenylalanine-tRNA ligase (EC 6.1.1.20) beta chain, cytosolic [validated] - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|14318497|ref|NP_116631.1| Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate bind [NCBI NR]
  • gi|1174509|sp|P15625.3|SYFA_YEAST RecName: Full=Phenylalanyl-tRNA synthetase alpha chain; AltName: Full=Phenylalanine--tRNA ligase alpha chain; Short=PheRS [NCBI NR]
  • Phenylalanyl-tRNA synthetase alpha chain OS=Saccharomyces cerevisiae GN=FRS2 PE=1 SV=3 [Swiss-Prot]
  • FRS2 Phenylalanine--tRNA ligase alpha chain, cytosolic [mips]
  • Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar [SGD]
  • FRS2, Chr VI from 93497-95008, reverse complement [yeast_orfs2]
  • Chr VI from 93497-95008, reverse complement [yeastorf3.fasta]
  • Chr VI from 95008-93497, reverse complement [yeastorf5.fasta]
  • FRS2 SGDID:S0001872, Chr VI from 95008-93497, reverse complement, Verified ORF [yeastflysequest.fasta]
  • Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar [Saccharomyces [nrdb_11152004_Chlamydomonas]
  • FRS2 SGDID:S000001872, Chr VI from 95008-93497, reverse complement, Verified ORF, "Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA sy [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • Phenylalanyl-tRNA synthetase alpha chain (Phenylalanine--tRNA ligase alpha chain) (PheRS) [nr-271106-contam.fasta]
  • cytoplasmic phenylalanyl-tRNA synthetase beta chain [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar; Frs2p [Saccha [nr-271106-contam.fasta]
  • FRS2 SGDID:S000001872, Chr VI from 95008-93497, reverse complement, Verified ORF, "Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • Phenylalanine--tRNA ligase alpha subunit OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FRS2 PE=1 SV=3 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • FRS2 SGDID:S000001872, Chr VI from 95010-93499, Genome Release 64-1-1, reverse complement, Verified ORF, "Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar" [yeast-030211-contam.fasta]
  • FRS2 SGDID:S000001872, Chr VI from 95010-93499, Genome Release 64-2-1, reverse complement, Verified ORF, "Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase; forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar" [20141208_orf_trans.fasta]
  • TR8159|c1_g1_i1|g.5657 ORF TR8159|c1_g1_i1|g.5657 TR8159|c1_g1_i1|m.5657 type:complete len:504 (+) TR8159|c1_g1_i1:147-1658(+) [Y12_S_cerevisiae-Sep2015-contam.fasta]
  • YFL022C SGDID:S000001872, Chr VI from 95010-93499, Genome Release 64-1-1, reverse complement, Verified ORF, "Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
  • ID=asmbl_9473|g.5697 ORF ID=asmbl_9473|g.5697 ID=asmbl_9473|m.5697 type:complete len:504 (+) ID=asmbl_9473:147-1658(+) [Y12_quiver_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 503 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article][TASLink to PubMed article]
    phenylalanine-tRNA ligase complex [TASLink to PubMed article]
    Biological Process: phenylalanyl-tRNA aminoacylation [TASLink to PubMed article]
    Molecular Function: phenylalanine-tRNA ligase activity [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDFQLEILK KLDELDEIKS TLATFPQHGS QDVLSALNSL KAHNKLEFSK VDTVTYDLTK  60
   61 EGAQILNEGS YEIKLVKLIQ ELGQLQIKDV MSKLGPQVGK VGQARAFKNG WIAKNASNEL 120
  121 ELSAKLQNTD LNELTDETQS ILAQIKNNSH LDSIDAKILN DLKKRKLIAQ GKITDFNVTK 180
  181 GPEFSTDLTK LETDLTSDMV STNAYKDLKF KPYNFNSQGV QISSGALHPL NKVREEFRQI 240
  241 FFSMGFTEMP SNQYVETGFW NFDALYVPQQ HPARDLQDTF YIKDPLTADL PDDKTYMDNI 300
  301 KAVHEQGRFG SIGYRYNWKP EECQKLVLRT HSTAISARML HDLAKDPKPT RLFSIDRVFR 360
  361 NEAVDATHLA EFHQVEGVLA DYNITLGDLI KFMEEFFERM GVTGLRFKPT YNPYTEPSME 420
  421 IFSWHEGLQK WVEIGNSGMF RPEMLESMGL PKDLRVLGWG LSLERPTMIK YKVQNIRELL 480
  481 GHKVSLDFIE TNPAARLDED LYE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) FRS1 FRS2
    View Details (MIPS) Mewes HW, et al. (2004) FRS1 FRS2 MSF1
    View Details Krogan NJ, et al. (2006) FRS1 FRS2 ILS1
    View Details Gavin AC, et al. (2006) FRS1 FRS2
    View Details Gavin AC, et al. (2002) FRS1 FRS2
    View Details Ho Y, et al. (2002) AAT2 ACH1 ACO1 AFR1 AHP1 ARC1 ARF1 ATP3 BGL2 CAR2 CBP6 CDC33 CLU1 COF1 COR1 CPR1 CYR1 CYS4 EGD1 ERG13 ERG6 FPR1 FRS2 GCD11 GCN3 GND1 GND2 GRX1 GUS1 HEF3 HHF1, HHF2 HXT7 LRO1 LSP1 MCX1 MET6 NDE1 NPA3 NTF2 OLA1 OYE2 PET10 PET9 PFK1 PIL1 PRM2 RNR2 RSN1 SAH1 SCP160 SEC53 SEN15 SES1 SLC1 SNU13 SOD1 TEF4 THS1 TIF1, TIF2 TMA19 TRP3 TRP5 TSA2 UBA1 VMA4 VMA5 VPS8 WTM1 YKU70 YNK1
    View Details Qiu et al. (2008) FRS1 FRS2 GUS1 MES1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..114] ORFEUS 9.66 MexR repressor
    2 View Details [115..503] PSI-BLAST 383.228787 Phenyl-tRNA synthetase (PheRS) alpha subunit, PheS

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • phenylalanine-tRNA ligase activity
    		•  13.8919118344182 bayes_pls_golite062009
  • ligase activity, forming carbon-oxygen bonds
    		•  12.5698315343202 bayes_pls_golite062009
  • ligase activity, forming aminoacyl-tRNA and related compounds
    		•  12.5698315343202 bayes_pls_golite062009
  • aminoacyl-tRNA ligase activity
    		•  12.5592545638101 bayes_pls_golite062009
  • ligase activity
    		•  6.92073480193262 bayes_pls_golite062009
  • glycine-tRNA ligase activity
    		•  2.61548498770105 bayes_pls_golite062009
  • threonine-tRNA ligase activity
    		•  2.18642354927 bayes_pls_golite062009
  • serine-tRNA ligase activity
    		•  2.07594942154162 bayes_pls_golite062009
  • catalytic activity
    		•  1.99372273395202 bayes_pls_golite062009
  • alanine-tRNA ligase activity
    		•  1.82594054955281 bayes_pls_golite062009
  • lysine-tRNA ligase activity
    		•  1.72324031407565 bayes_pls_golite062009
  • histidine-tRNA ligase activity
    		•  1.72215103383322 bayes_pls_golite062009
  • asparagine-tRNA ligase activity
    		•  0.921492123574877 bayes_pls_golite062009
  • binding
    		•  0.705666054154871 bayes_pls_golite062009
  • aspartate-tRNA ligase activity
    		•  0.00572514744734753 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle