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Protein Overview: SWI4

General Information:
Name(s) found: SWI4 / YER111C [SGD]
Description(s) found:
Found 23 descriptions.
SHOW ALL
  • DNA binding component of the SBF complex (Swi4p-Swi6p), a transcriptional activator that in concert with MBF (Mbp1-Swi6p) regulates late G1-specific transcription of targets including cyclins and genes required for DNA synthesis and repair [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1093 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    Biological Process: transcription [IMPLink to PubMed article]
    G1/S transition of mitotic cell cycle [IGILink to PubMed article]
    Molecular Function: DNA binding [IDALink to PubMed article]
    transcription factor activity [IMPLink to PubMed article][IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPFDVLISNQ KDNTNHQNIT PISKSVLLAP HSNHPVIEIA TYSETDVYEC YIRGFETKIV  60
   61 MRRTKDDWIN ITQVFKIAQF SKTKRTKILE KESNDMQHEK VQGGYGRFQG TWIPLDSAKF 120
  121 LVNKYEIIDP VVNSILTFQF DPNNPPPKRS KNSILRKTSP GTKITSPSSY NKTPRKKNSS 180
  181 SSTSATTTAA NKKGKKNASI NQPNPSPLQN LVFQTPQQFQ VNSSMNIMNN NDNHTTMNFN 240
  241 NDTRHNLINN ISNNSNQSTI IQQQKSIHEN SFNNNYSATQ KPLQFFPIPT NLQNKNVALN 300
  301 NPNNNDSNSY SHNIDNVINS SNNNNNGNNN NLIIVPDGPM QSQQQQQHHH EYLTNNFNHS 360
  361 MMDSITNGNS KKRRKKLNQS NEQQFYNQQE KIQRHFKLMK QPLLWQSFQN PNDHHNEYCD 420
  421 SNGSNNNNNT VASNGSSIEV FSSNENDNSM NMSSRSMTPF SAGNTSSQNK LENKMTDQEY 480
  481 KQTILTILSS ERSSDVDQAL LATLYPAPKN FNINFEIDDQ GHTPLHWATA MANIPLIKML 540
  541 ITLNANALQC NKLGFNCITK SIFYNNCYKE NAFDEIISIL KICLITPDVN GRLPFHYLIE 600
  601 LSVNKSKNPM IIKSYMDSII LSLGQQDYNL LKICLNYQDN IGNTPLHLSA LNLNFEVYNR 660
  661 LVYLGASTDI LNLDNESPAS IMNKFNTPAG GSNSRNNNTK ADRKLARNLP QKNYYQQQQQ 720
  721 QQQPQNNVKI PKIIKTQHPD KEDSTADVNI AKTDSEVNES QYLHSNQPNS TNMNTIMEDL 780
  781 SNINSFVTSS VIKDIKSTPS KILENSPILY RRRSQSISDE KEKAKDNENQ VEKKKDPLNS 840
  841 VKTAMPSLES PSSLLPIQMS PLGKYSKPLS QQINKLNTKV SSLQRIMGEE IKNLDNEVVE 900
  901 TESSISNNKK RLITIAHQIE DAFDSVSNKT PINSISDLQS RIKETSSKLN SEKQNFIQSL 960
  961 EKSQALKLAT IVQDEESKVD MNTNSSSHPE KQEDEEPIPK STSETSSPKN TKADAKFSNT1020
 1021 VQESYDVNET LRLATELTIL QFKRRMTTLK ISEAKSKINS SVKLDKYRNL IGITIENIDS1080
 1081 KLDDIEKDLR ANA

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) SWI4 SWI6
    View Details (MIPS) Mewes HW, et al. (2004) SWI4 SWI6
    View Details Krogan NJ, et al. (2006) BUD2 MBP1 MSA2 SWI4 SWI6 WHI5
    View Details Gavin AC, et al. (2006) SWI4 SWI6
    View Details Ho Y, et al. (2002) ASF1 CDC13 EDE1 KAP95 PTC2 RAD53 SRP1 SWI4 TBF1 UTP22 YTA7

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #02 Alpha Factor Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen RAD4 SWI4 1 Unpublished Fields Lab Data
    View Screen CAB2 SWI4 1 Unpublished Fields Lab Data
    View Screen NOP13 SWI4 1 Unpublished Fields Lab Data
    View Screen YIF1 SWI4 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SWI4 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..165] PSI-BLAST 259.38764 DNA-binding domain of Mlu1-box binding protein MBP1
    2 View Details [166..420] MSA 3.381996 View MSA. No confident structure predictions are available.
    3 View Details [421..510] PSI-BLAST 26.154902 GA bindinig protein (GABP) beta 1
    4 View Details [511..690] PSI-BLAST 127.457575 Swi6 ankyrin-repeat fragment
    5 View Details [691..1093] MSA 30.801997 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  4.36949648004482 bayes_pls_golite062009
  • DNA binding
    		•  4.06494205639151 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.98559547948274 bayes_pls_golite062009
  • transcription factor activity
    		•  3.87642218322379 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  3.19892138828988 bayes_pls_golite062009
  • binding
    		•  2.79149251200147 bayes_pls_golite062009
  • protein binding
    		•  1.55473080522232 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.838109968340069 bayes_pls_golite062009
    2 No functions predicted.
    3
    Term Confidence Notes
  • protein binding
    		•  2.69918165732603 bayes_pls_golite062009
  • binding
    		•  2.60916417202222 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.37103377984038 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.8957142857582 bayes_pls_golite062009
  • DNA binding
    		•  1.78305438715057 bayes_pls_golite062009
  • transcription activator activity
    		•  1.6418915400902 bayes_pls_golite062009
  • transcription factor activity
    		•  1.2667825651547 bayes_pls_golite062009
  • transcription factor binding
    		•  1.06366405671195 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.949906091645366 bayes_pls_golite062009
  • structural molecule activity
    		•  0.648591660171134 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.63796241781934 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.32425530306039 bayes_pls_golite062009
  • cyclin-dependent protein kinase regulator activity
    		•  0.0462605323512499 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle