Protein Overview: HPR1

General Information:
Name(s) found:	HPR1 / YDR138W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|665671\|emb\|CAA88220.1\| Hpr1p [Saccharomyces cerevisiae] [NCBI NR] gi\|6320342\|ref\|NP_010422.1\| Subunit of THO/TREX complexes that couple transcription elongation with mitotic recombination and with mRNA metabolism and export, subunit of an RNA Pol II complex; regulates lifespan; involved in telomere maintenance; similar [NCBI NR] gi\|2507048\|sp\|P17629.2\|HPR1_YEAST RecName: Full=THO complex subunit HPR1; AltName: Full=Hyperrecombination protein 1 [NCBI NR] pir\|\|S51866 HPR1 protein - yeast (Saccharomyces cerevisiae) [NCBI NR] THO complex subunit HPR1 OS=Saccharomyces cerevisiae GN=HPR1 PE=1 SV=2 [Swiss-Prot] HPR1 Hyperrecombination protein related to Top1p [mips] Subunit of THO/TREX complexes that couple transcription elongation with mitotic recombination and with mRNA metabolism and export, subunit of an RNA Pol II complex; regulates lifespan; involved in telomere maintenance; similar to Top1p [SGD] HPR1, Chr IV from 730571-732829 [yeast_orfs2] Chr IV from 730571-732829 [yeastorf3.fasta] (P17629) HPR1 protein [4932.FASTACCERV.txt] HPR1 SGDID:S0002545, Chr IV from 730572-732830, Verified ORF [yeastflysequest.fasta] HPR1 SGDID:S0002545, Chr IV from 730573-732831, Verified ORF [10112005cervSGD.fasta] Hpr1p [Saccharomyces cerevisiae]gi\|665671\|emb\|CAA88220.1\| Hpr1p [Saccharomyces cerevisiae]gi\|2507048\|sp\|P17629\|HPR1_YEAST HPR1 proteingi\|1077165\|pir\|\|S51866 HPR1 protein - yeast (Saccharomyces cerevisiae) [nrdb_11152004_Chlamydomonas] HPR1 SGDID:S000002545, Chr IV from 730573-732831, Verified ORF, "Subunit of THO/TREX, related complexes that couple transcription elongation with mitotic recombination and elongation with mRNA metabolism and export, subunit of an RNA Pol II complex; regul [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] HPR1 SGDID:S000002545, Chr IV from 730575-732833, Verified ORF, "Subunit of THO/TREX complexes that couple transcription elongation with mitotic recombination and with mRNA metabolism and export, subunit of an RNA Pol II complex; regulates lifespan; invol [yeast-contam.fasta] HPR1 SGDID:S000002545, Chr IV from 730576-732834, Verified ORF, "Subunit of THO/TREX complexes that couple transcription elongation with mitotic recombination and with mRNA metabolism and export, subunit of an RNA Pol II complex; regulates lifespan; invol [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta] Hpr1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Subunit of THO/TREX complexes that couple transcription elongation with mitotic recombination and with mRNA metabolism and export, subunit of an RNA Pol II complex; regulates lifespan; involved in telomere maintenance; similar to Top1p; Hpr1p [Saccharomyc [nr-271106-contam.fasta] Protein HPR1 [nr-271106-contam.fasta] HPR1 SGDID:S000002545, Chr IV from 730576-732834, Verified ORF, "Subunit of THO/TREX complexes that couple transcription elongation with mitotic recombination and with mRNA metabolism and export, subunit of an RNA Pol II complex; regulates lifespan; involved in telomere maintenance; similar to Top1p" [yeast-bovrabprots.fasta] HPR1 SGDID:S000002545, Chr IV from 730575-732833, Verified ORF, "Subunit of THO/TREX complexes that couple transcription elongation with mitotic recombination and with mRNA metabolism and export, subunit of an RNA Pol II complex; regulates lifespan; involved in telomere maintenance; similar to Top1p" [yeast-contam_custom.fasta] [chemostatdb.fasta] THO complex subunit HPR1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HPR1 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] HPR1 SGDID:S000002545, Chr IV from 730578-732836, Genome Release 64-1-1, Verified ORF, "Subunit of THO/TREX complexes that couple transcription elongation with mitotic recombination and with mRNA metabolism and export, subunit of an RNA Pol II complex; regulates lifespan; involved in telomere maintenance; similar to Top1p" [yeast-030211-contam.fasta] HPR1 SGDID:S000002545, Chr IV from 730578-732836, Genome Release 64-2-1, Verified ORF, "Subunit of THO/TREX complexes; this complex couple transcription elongation with mitotic recombination and with mRNA metabolism and export, subunit of an RNA Pol II complex; regulates lifespan; involved in telomere maintenance; similar to Top1p" [20141208_orf_trans.fasta] YDR138W SGDID:S000002545, Chr IV from 730578-732836, Genome Release 64-1-1, Verified ORF, "Subunit of THO/TREX complexes that couple transcription elongation with mitotic recombination and with mRNA metabolism and export, subunit of an RNA Pol II complex; regulates lifespan; involved in telomere maintenance; similar to Top1p" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	752 amino acids
Gene Ontology:
Cellular Component:	Cdc73/Paf1 complex [IPI] THO complex [IMP][IPI]
Biological Process:	mRNA export from nucleus [IGI][IMP] DNA recombination [IMP ] telomere maintenance [IMP] response to DNA damage stimulus [IMP] RNA elongation from RNA polymerase II promoter [IMP]
Molecular Function:	nucleic acid binding [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNTEELIQN SIGFLQKTFK ALPVSFDSIR HEPLPSSMLH ASVLNFEWEP LEKNISAIHD  60
   61 RDSLIDIILK RFIIDSMTNA IEDEEENNLE KGLLNSCIGL DFVYNSRFNR SNPASWGNTF 120
  121 FELFSTIIDL LNSPSTFLKF WPYAESRIEW FKMNTSVEPV SLGESNLISY KQPLYEKLRH 180
  181 WNDILAKLEN NDILNTVKHY NMKYKLENFL SELLPINEES NFNRSASISA LQESDNEWNR 240
  241 SARERESNRS SDVIFAADYN FVFYHLIICP IEFAFSDLEY KNDVDRSLSP LLDAILEIEE 300
  301 NFYSKIKMNN RTRYSLEEAL NTEYYANYDV MTPKLPVYMK HSNAMKMDRN EFWANLQNIK 360
  361 ESDDYTLRPT IMDISLSNTT CLYKQLTQED DDYYRKQFIL QLCFTTNLIR NLISSDETRN 420
  421 FYKSCYLREN PLSDIDFENL DEVNKKRGLN LCSYICDNRV LKFYKIKDPD FYRVIRKLMS 480
  481 SDEKFTTAKI DGFKEFQNFR ISKEKIPPPA FDETFKKFTF IKMGNKLINN VWKIPTGLDK 540
  541 IEQEVKKPEG VYEAAQAKWE SKISSETSGG EAKDEIIRQW QTLRFLRSRY LFDFDKVNEK 600
  601 TGVDGLFEEP RKVEALDDSF KEKLLYKINQ EHRKKLQDAR EYKIGKERKK RALEEEASFP 660
  661 EREQKIKSQR INSASQTEGD ELKSEQTQPK GEISEENTKI KSSEVSSQDP DSGVAGEFAP 720
  721 QNTTAQLENP KTEDNNAATS NISNGSSTQD MK

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		GBP2 HPR1 HRB1 MFT1 SUB2 TEX1 THO2 THP2
View Details	Krogan NJ, et al. (2006)		CPR7 GBP2 GVP36 HHO1 HPR1 HRB1 MFT1 SUB2 TEX1 THO2 THP2 ULS1 YNL140C
View Details	Gavin AC, et al. (2006)		HPR1 HRB1 MFT1 SUB2 TEX1 THO2 THP2
View Details	Ho Y, et al. (2002)		AHA1 DIS3 EAF3 FIP1 GBP2 HAS1 HPR1 IMD3 KAP95 MES1 MFT1 NAM8 NOP6 NUP1 NUP2 NUP60 PAP1 PCT1 PRB1 PSK2 REB1 RNT1 RPN1 RRP4 RRP43 RRP6 RTT103 SET1 SFP1 SGS1 SIF2 SIN3 SNU56 SRP1 SSK2 STO1 SUB2 SUV3 SWD3 TEX1 THO2 THP2 TRA1 UME1 YPR090W YRA1
View Details	Qiu et al. (2008)		HPR1 MFT1 SUB2 THO2 THP2 YRA1

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	CEP3	sample cbf3 from feb 2005	Sandall S, et all (2006)
View Run	BOI1	Sample boi1 with gst from october 2005	McCusker D, et al (2007)
View Run	MLP2	#25 Asynchronous Prep3-TiO2 Flowthrough	Keck JM, et al. (2011)
View Run	MLP2	#26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2	Keck JM, et al. (2011)
View Run	MLP2	#13 Mitotic Prep2-TiO2 Phosphopeptide enrichment	Keck JM, et al. (2011)
View Run	MLP2	#12 Mitotic Prep1-TiO2 Flowthrough	Keck JM, et al. (2011)
View Run	None Entered	#17 Mitotic Prep3-TiO2 Phosphopeptide enrichment	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	LIA1	HPR1	1	Unpublished Fields Lab Data
View Screen	RRB1	HPR1	1	Unpublished Fields Lab Data
View Screen	SPT21	HPR1	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	HPR1	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..752]	deduced	N/A	No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.97

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2