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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Sec27. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 29 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
ARG4
  • cytosol
  • arginine biosynthetic process
  • argininosuccinate lyase activity
  • AYR1
  • lipid particle
  • cytoplasm
  • mitochondrion
  • endoplasmic reticulum
  • mitochondrial outer membrane
  • phosphatidic acid biosynthetic process
  • acylglycerone-phosphate reductase activity
  • COR1
  • mitochondrion
  • mitochondrial respiratory chain complex III
  • aerobic respiration
  • ubiquinol-cytochrome-c reductase activity
  • CPR6
  • cytoplasm
  • protein folding
  • peptidyl-prolyl cis-trans isomerase activity
  • unfolded protein binding
  • ERG27
  • endoplasmic reticulum membrane
  • endoplasmic reticulum
  • mitochondrial outer membrane
  • ergosterol biosynthetic process
  • 3-keto sterol reductase activity
  • GPT2
  • cytoplasm
  • endoplasmic reticulum
  • phospholipid biosynthetic process
  • glycerol-3-phosphate O-acyltransferase activity
  • LIA1
  • nucleus
  • cytoplasm
  • ribosome biogenesis
  • microtubule cytoskeleton organization
  • protein binding
  • deoxyhypusine monooxygenase activity
  • MAE1
  • mitochondrion
  • cellular amino acid metabolic process
  • pyruvate metabolic process
  • malic enzyme activity
  • OM45
  • integral to mitochondrial outer membrane
  • mitochondrion
  • mitochondrial outer membrane
  • biological_process
  • molecular_function
  • PCT1
  • nuclear envelope
  • nucleus
  • Golgi apparatus
  • CDP-choline pathway
  • phosphatidylcholine biosynthetic process
  • choline-phosphate cytidylyltransferase activity
  • PDA1
  • mitochondrial pyruvate dehydrogenase complex
  • mitochondrion
  • mitochondrial nucleoid
  • pyruvate metabolic process
  • pyruvate dehydrogenase (acetyl-transferring) activity
  • PET10
  • lipid particle
  • aerobic respiration
  • molecular_function
  • PET9
  • mitochondrion
  • mitochondrial inner membrane
  • anaerobic respiration
  • mitochondrial transport
  • aerobic respiration
  • ATP transport
  • ADP transport
  • ATP:ADP antiporter activity
  • PIL1
  • cytoplasm
  • mitochondrion
  • mitochondrial outer membrane
  • eisosome
  • response to heat
  • protein localization
  • endocytosis
  • protein kinase inhibitor activity
  • PRE10
  • proteasome core complex, alpha-subunit complex
  • ubiquitin-dependent protein catabolic process
  • endopeptidase activity
  • PRO3
  • cytoplasm
  • proline biosynthetic process
  • pyrroline-5-carboxylate reductase activity
  • RET2
  • COPI vesicle coat
  • ER to Golgi vesicle-mediated transport
  • retrograde vesicle-mediated transport, Golgi to ER
  • protein binding
  • RNR2
  • nucleus
  • cytoplasm
  • ribonucleoside-diphosphate reductase complex
  • DNA replication
  • ribonucleoside-diphosphate reductase activity
  • RTN2
  • endoplasmic reticulum
  • biological_process
  • molecular_function
  • RVS161
  • mating projection
  • membrane raft
  • actin cortical patch
  • bipolar cellular bud site selection
  • response to osmotic stress
  • endocytosis
  • cytoskeletal protein binding
  • SEC18
  • cytoplasm
  • extrinsic to plasma membrane
  • vacuole inheritance
  • ER to Golgi vesicle-mediated transport
  • vacuole fusion, non-autophagic
  • ATPase activity
  • SEC21
  • endosome
  • COPI vesicle coat
  • ER to Golgi vesicle-mediated transport
  • retrograde vesicle-mediated transport, Golgi to ER
  • molecular_function
  • SEC26
  • coated vesicle
  • COPI vesicle coat
  • ER to Golgi vesicle-mediated transport
  • molecular_function
  • SEC27
  • COPI vesicle coat
  • ER to Golgi vesicle-mediated transport
  • retrograde vesicle-mediated transport, Golgi to ER
  • molecular_function
  • SEC28
  • endosome
  • COPI vesicle coat
  • vesicle coating
  • ER to Golgi vesicle-mediated transport
  • molecular_function
  • TIF34
  • multi-eIF complex
  • eukaryotic translation initiation factor 3 complex
  • translational initiation
  • translation initiation factor activity
  • TIF35
  • eukaryotic translation initiation factor 3 complex
  • translational initiation
  • translation initiation factor activity
  • TPA1
  • nucleus
  • ribosome biogenesis
  • translational readthrough
  • mRNA catabolic process
  • nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
  • molecular_function
  • YNL181W
  • nuclear envelope
  • endoplasmic reticulum
  • biological_process
  • oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor
  • oxidoreductase activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    COPI coated vesicle membrane 1.8006E-10 29 9 5 6292
    COPI vesicle coat 1.8006E-10 29 9 5 6292
    Golgi-associated vesicle membrane 6.1043E-9 29 16 5 6292
    COPI-coated vesicle 2.7988E-8 29 21 5 6292
    vesicle coat 3.6717E-7 29 34 5 6292
    coated vesicle membrane 4.27E-7 29 35 5 6292
    cytoplasmic vesicle membrane 4.27E-7 29 35 5 6292
    vesicle membrane 4.27E-7 29 35 5 6292
    membrane coat 6.5394E-7 29 38 5 6292
    coated membrane 6.5394E-7 29 38 5 6292
    cytoplasmic vesicle part 7.4772E-7 29 39 5 6292
    Golgi-associated vesicle 8.5181E-7 29 40 5 6292
    Golgi membrane 2.3986E-6 29 49 5 6292
    cytoplasmic part 1.3595E-5 29 2482 23 6292
    cytoplasm 1.6092E-5 29 3552 27 6292
    coated vesicle 3.2763E-5 29 83 5 6292
    Golgi apparatus 1.0425E-4 29 171 6 6292
    membrane-bounded vesicle 1.111E-4 29 107 5 6292
    cytoplasmic vesicle 1.111E-4 29 107 5 6292
    cytoplasmic membrane-bounded vesicle 1.111E-4 29 107 5 6292
    vesicle 1.2668E-4 29 110 5 6292
    organelle membrane 1.4106E-4 29 692 11 6292
    Golgi apparatus part 1.8367E-4 29 119 5 6292
    endomembrane system 3.1511E-4 29 398 8 6292
    eukaryotic translation initiation factor 3 complex 4.2467E-4 29 7 2 6292
    membrane part 4.8333E-4 29 662 10 6292
    mitochondrial outer membrane 7.6856E-4 29 92 4 6292
    intracellular part 8.7176E-4 29 4938 29 6292
    intracellular 1.0831E-3 29 4975 29 6292
    mitochondrial membrane 1.1266E-3 29 266 6 6292
    membrane 1.3108E-3 29 1198 13 6292
    envelope 1.5406E-3 29 505 8 6292
    organelle envelope 1.5406E-3 29 505 8 6292
    mitochondrial envelope 2.5537E-3 29 312 6 6292
    protein complex 2.8676E-3 29 1137 12 6292
    mitochondrial part 4.8367E-3 29 475 7 6292
    outer membrane 8.4595E-3 29 178 4 6292
    organelle outer membrane 8.4595E-3 29 178 4 6292
    eisosome 9.1975E-3 29 2 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ER to Golgi vesicle-mediated transport 1.6363E-6 29 83 6 6292
    Golgi vesicle transport 9.4494E-5 29 168 6 6292
    vesicle-mediated transport 1.0561E-4 29 340 8 6292
    retrograde vesicle-mediated transport, Golgi to ER 2.1318E-4 29 26 3 6292
    lipid biosynthetic process 2.7684E-3 29 130 4 6292
    phospholipid biosynthetic process 2.774E-3 29 62 3 6292
    translational readthrough 4.609E-3 29 1 1 6292
    phosphatidic acid metabolic process 4.609E-3 29 1 1 6292
    CDP-choline pathway 4.609E-3 29 1 1 6292
    ADP transport 4.609E-3 29 1 1 6292
    phosphatidic acid biosynthetic process 4.609E-3 29 1 1 6292
    aerobic respiration 6.3163E-3 29 83 3 6292
    glutamine family amino acid biosynthetic process 7.1991E-3 29 28 2 6292
    anaerobic respiration 9.1975E-3 29 2 1 6292
    phospholipid metabolic process 9.4365E-3 29 96 3 6292
    organophosphate metabolic process 9.7077E-3 29 97 3 6292
    cellular respiration 9.7077E-3 29 97 3 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    oxidoreductase activity 2.831E-6 29 281 9 6292
    oxidoreductase activity, acting on CH or CH2 groups 2.0338E-4 29 5 2 6292
    oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor 4.609E-3 29 1 1 6292
    pyrroline-5-carboxylate reductase activity 4.609E-3 29 1 1 6292
    acylglycerone-phosphate reductase activity 4.609E-3 29 1 1 6292
    malic enzyme activity 4.609E-3 29 1 1 6292
    choline-phosphate cytidylyltransferase activity 4.609E-3 29 1 1 6292
    argininosuccinate lyase activity 4.609E-3 29 1 1 6292
    3-keto sterol reductase activity 4.609E-3 29 1 1 6292
    deoxyhypusine monooxygenase activity 4.609E-3 29 1 1 6292
    oxidoreductase activity, acting on CH-OH group of donors 5.9015E-3 29 81 3 6292
    translation initiation factor activity 6.7039E-3 29 27 2 6292
    amidine-lyase activity 9.1975E-3 29 2 1 6292
    glycerol-3-phosphate O-acyltransferase activity 9.1975E-3 29 2 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle