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Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate. Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH + H+. Also decarboxylates oxaloacetate. Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. Catalysis of the reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH + H+. Does not decarboxylate oxaloacetate. Catalysis of the reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH + H+. Also decarboxylates oxaloacetate.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: malic enzyme activity
Acc: GO:0004470
Aspect: Molecular Function
Desc: Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate.
Synonyms:
  • pyruvic-malic carboxylase activity
Proteins in PDR annotated with:
   This term: 26 [Search]
   Term or descendants: 49 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004470 - malic enzyme activity (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle