YRC Public Data Repository - Protein Complex GO Analysis

Complex Overview

From Publication:	Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes:	This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Fyv14. The topolgies of protein complexes in this experiment are unknown.
Complex Size:	40 proteins

Complex Member Proteins

Protein	GO Cellular Component	GO Biological Process	GO Molecular Function
CBF5	box H/ACA snoRNP complex nuclear outer membrane nucleolus	rRNA pseudouridine synthesis ribosome biogenesis	pseudouridylate synthase activity
CBP2	mitochondrion	Group I intron splicing	RNA binding
CCM1	mitochondrion	biological_process	molecular_function
CDC33	nucleus eukaryotic translation initiation factor 4F complex cytoplasm ribosome	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay translational initiation	translation initiation factor activity
CIC1	proteasome complex nucleolus	protein catabolic process ribosomal large subunit biogenesis ribosome biogenesis	protein binding, bridging
DBP7	nuclear outer membrane nucleolus	ribosome biogenesis ribosomal large subunit assembly	ATP-dependent RNA helicase activity
ENP2	nucleolus	ribosome biogenesis rRNA processing	molecular_function
GBP2	nucleus	telomere maintenance poly(A)+ mRNA export from nucleus	RNA binding telomeric DNA binding
HAS1	nuclear envelope nucleolus	ribosome biogenesis rRNA processing	RNA binding RNA-dependent ATPase activity ATP-dependent RNA helicase activity
HMO1	nucleus nuclear chromatin cytoplasm nucleolus	telomere maintenance plasmid maintenance	RNA polymerase I transcription factor activity single-stranded DNA binding
HTB2	nuclear nucleosome	chromatin assembly or disassembly	DNA binding
IMD1
IMD3	cytoplasm	GTP biosynthetic process	IMP dehydrogenase activity
ISA1	mitochondrial matrix	iron ion transport telomere maintenance	molecular_function
KRE33	nucleolus	ribosome biogenesis	molecular_function
KRI1	nucleolus	ribosome biogenesis	molecular_function
MGM101	mitochondrial chromosome mitochondrion mitochondrial nucleoid	DNA repair mitochondrial genome maintenance	DNA binding
MSS116	mitochondrial matrix mitochondrion	RNA splicing	RNA binding RNA-dependent ATPase activity ATP-dependent RNA helicase activity
NOC2	nucleus Noc2p-Noc3p complex mitochondrion Noc1p-Noc2p complex	ribosomal subunit export from nucleus ribosome biogenesis ribosome assembly	molecular_function
NOP12	nucleolus	rRNA metabolic process	RNA binding
NOP6	nucleolus	rRNA processing	molecular_function
NPL3	nucleus cytoplasm	mRNA export from nucleus pseudohyphal growth	poly(A) RNA binding mRNA binding
PET127	mitochondrion mitochondrial envelope	RNA processing	molecular_function
POL5	nucleolus	DNA replication rRNA transcription	DNA-directed DNA polymerase activity
PRP43	mitochondrion spliceosomal complex nuclear outer membrane	maturation of SSU-rRNA ribosomal large subunit biogenesis ribosome biogenesis rRNA processing processing of 27S pre-rRNA	ATP-dependent RNA helicase activity
PUF6	nucleus nucleolus	regulation of transcription, mating-type specific ribosome biogenesis	mRNA binding specific transcriptional repressor activity
PWP1	nucleus cytoplasm nucleolus	rRNA processing	molecular_function
RLI1	nucleus cytoplasm	ribosomal subunit export from nucleus ribosomal large subunit biogenesis translational initiation	ATPase activity iron ion binding
RRP12	nucleus ribosome	maturation of SSU-rRNA ribosome biogenesis	molecular_function
RRP5	nuclear outer membrane nucleolus small nucleolar ribonucleoprotein complex	maturation of SSU-rRNA ribosome biogenesis rRNA processing	RNA binding snoRNA binding rRNA primary transcript binding
TIF4631	eukaryotic translation initiation factor 4F complex mitochondrion ribosome	ribosome biogenesis translational initiation	translation initiation factor activity
TRA1	NuA4 histone acetyltransferase complex SLIK (SAGA-like) complex SAGA complex histone acetyltransferase complex	DNA repair histone acetylation regulation of transcription from RNA polymerase II promoter	histone acetyltransferase activity
TSR1	cytoplasm nucleolus	ribosome biogenesis rRNA processing	ribonucleoprotein binding
URB1	nucleolus	rRNA processing processing of 27S pre-rRNA	molecular_function
URB2	nucleolus	rRNA metabolic process ribosome biogenesis	molecular_function
UTP10	mitochondrion small nucleolar ribonucleoprotein complex	maturation of SSU-rRNA ribosome biogenesis	snoRNA binding
UTP20	cytoplasm nuclear outer membrane nucleolus small nucleolar ribonucleoprotein complex	endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ribosome biogenesis endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) rRNA processing	snoRNA binding
YPP1	cytoplasm ribosome plasma membrane	MAPKKK cascade	molecular_function
YRA1	transcription export complex	mRNA export from nucleus	RNA binding
YTM1	nucleus nucleolus	ribosomal large subunit biogenesis ribosome biogenesis	molecular_function

Cellular Component Analysis

Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
nucleolus	1.0066E-19	40	211	20	6292
nuclear lumen	2.347E-14	40	453	21	6292
organelle lumen	2.6286E-14	40	660	24	6292
intracellular organelle lumen	2.6286E-14	40	660	24	6292
membrane-enclosed lumen	9.9176E-14	40	700	24	6292
non-membrane-bounded organelle	1.1427E-12	40	959	26	6292
intracellular non-membrane-bounded organelle	1.1427E-12	40	959	26	6292
nuclear part	2.0212E-9	40	1103	24	6292
nucleus	2.2574E-7	40	2041	29	6292
membrane-bounded organelle	4.0266E-6	40	3771	37	6292
intracellular membrane-bounded organelle	4.0266E-6	40	3771	37	6292
intracellular organelle	6.5685E-6	40	4070	38	6292
organelle	6.6248E-6	40	4071	38	6292
intracellular organelle part	1.4188E-5	40	2282	28	6292
organelle part	1.4188E-5	40	2282	28	6292
nuclear outer membrane	1.9165E-4	40	86	5	6292
eukaryotic translation initiation factor 4F complex	2.3456E-4	40	4	2	6292
nuclear membrane	3.3697E-4	40	97	5	6292
intracellular part	7.1918E-4	40	4938	39	6292
intracellular	9.3977E-4	40	4975	39	6292
small nucleolar ribonucleoprotein complex	1.0554E-3	40	72	4	6292
ribonucleoprotein complex	1.0886E-3	40	514	10	6292
nuclear envelope	1.4513E-3	40	199	6	6292
outer membrane	5.0506E-3	40	178	5	6292
organelle outer membrane	5.0506E-3	40	178	5	6292

Biological Process Analysis

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
ribosome biogenesis	4.6156E-18	40	346	22	6292
ribonucleoprotein complex biogenesis	2.484E-17	40	374	22	6292
rRNA metabolic process	3.9441E-14	40	137	14	6292
rRNA processing	1.0294E-11	40	128	12	6292
cellular component biogenesis	1.0376E-11	40	694	22	6292
ncRNA metabolic process	2.2701E-10	40	257	14	6292
RNA processing	3.9551E-9	40	380	15	6292
ncRNA processing	4.4835E-9	40	215	12	6292
RNA metabolic process	3.7254E-8	40	954	21	6292
nucleic acid metabolic process	5.9261E-8	40	1415	25	6292
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	9.0231E-8	40	1566	26	6292
cellular nitrogen compound metabolic process	1.2463E-6	40	1770	26	6292
nitrogen compound metabolic process	1.5963E-6	40	1791	26	6292
gene expression	6.4029E-6	40	1283	21	6292
macromolecule metabolic process	2.653E-5	40	2349	28	6292
maturation of SSU-rRNA	3.1234E-5	40	59	5	6292
ribosomal large subunit biogenesis	5.0115E-5	40	65	5	6292
cellular macromolecule metabolic process	5.7646E-5	40	2285	27	6292
cellular process	1.1683E-4	40	4426	38	6292
nuclear export	4.4514E-4	40	103	5	6292
primary metabolic process	6.0732E-4	40	2896	29	6292
nuclear transport	1.2839E-3	40	130	5	6292
nucleocytoplasmic transport	1.2839E-3	40	130	5	6292
translational initiation	2.3016E-3	40	42	3	6292
metabolic process	3.3468E-3	40	3157	29	6292
cellular metabolic process	4.2676E-3	40	3033	28	6292
processing of 27S pre-rRNA	4.4702E-3	40	16	2	6292
mRNA export from nucleus	8.9661E-3	40	68	3	6292
mRNA transport	8.9661E-3	40	68	3	6292

Molecular Function Analysis

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
nucleic acid binding	1.1404E-6	40	666	16	6292
RNA binding	1.141E-5	40	367	11	6292
ATP-dependent RNA helicase activity	2.5691E-5	40	28	4	6292
RNA-dependent ATPase activity	2.9665E-5	40	29	4	6292
binding	1.1947E-4	40	1294	19	6292
RNA helicase activity	1.3172E-4	40	42	4	6292
ATP-dependent helicase activity	2.2277E-4	40	48	4	6292
purine NTP-dependent helicase activity	2.2277E-4	40	48	4	6292
snoRNA binding	9.4586E-4	40	31	3	6292
helicase activity	1.7928E-3	40	83	4	6292

View Protein Complex Details

Complex Overview

Complex Member Proteins

Cellular Component Analysis

Biological Process Analysis

Molecular Function Analysis