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The process whereby a signal is conveyed via the transfer of one or more phosphate groups. A cascade of protein kinase activities, culminating in the phosphorylation and activation of a member of the JUN kinase subfamily of stress-activated protein kinases, which in turn are a subfamily of mitogen-activated protein (MAP) kinases that is activated primarily by cytokines and exposure to environmental stress. A MAPKKK cascade culminating in the phosphorylation and activation of a MAP kinase that occurs in the context of conjugation with cellular fusion. The directed movement of a MAP kinase to the nucleus upon activation. A series of molecular signals in which a stress-activated MAP kinase cascade relays one or more of the signals; MAP kinase cascades involve at least three protein kinase activities and culminate in the phosphorylation and activation of a MAP kinase. Any process that terminates the activity of the active enzyme MAP kinase kinase. A series of reactions that occur within the cell, mediated by protein kinases, which occurs as a result of a single trigger reaction or compound. The process whereby a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. Any process that terminates the activity of the active enzyme MAP kinase. Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade. A MAPKKK cascade culminating in the phosphorylation and activation of a MAP kinase that occurs in the context of an innate immune response, a defense response mediated by germline encoded components that directly recognize components of potential pathogens. A MAPKKK cascade culminating in the phosphorylation and activation of a MAP kinase that occurs in the context of cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells. MAPKKK cascade involved in signal transduction in response to change in osmotic conditions. The initiation of the activity of the inactive enzyme MAP kinase by phosphorylation by a MAPKK. The initiation of the activity of the inactive enzyme MAP kinase kinase by phosphorylation by a MAPKKK. Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase. A cascade of at least three protein kinase activities culminating in the phosphorylation and activation of a MAP kinase. MAPKKK cascades lie downstream of numerous signaling pathways. Any process that terminates the activity of the active enzyme MAP kinase kinase kinase. The process whereby a signal is passed from the epidermal growth factor receptor (EGFR) to components of the MAPKKK cascade, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade. A cascade of protein kinase activities, culminating in the phosphorylation and activation of big MAP kinase (BMK1/ERK5), which is a type of mitogen-activated protein (MAP) kinase. A cascade of protein kinase activities, culminating in the phosphorylation and activation of either the ERK1 or ERK2 kinases, which in turn are a subfamily of mitogen-activated protein (MAP) kinases. Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: MAPKKK cascade
Acc: GO:0000165
Aspect: Biological Process
Desc: A cascade of at least three protein kinase activities culminating in the phosphorylation and activation of a MAP kinase. MAPKKK cascades lie downstream of numerous signaling pathways.
Synonyms:
  • MAPK cascade
  • MAP kinase kinase kinase cascade
  • MAPKKK cascade during sporulation
  • ERK/MAPK cascade
  • MAP kinase cascade
  • MAPK signalling
  • MAPK signaling
Proteins in PDR annotated with:
   This term: 131 [Search]
   Term or descendants: 784 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0000165 - MAPKKK cascade (interactive image map)
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