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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Grr1. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 13 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
CDC53
  • SCF ubiquitin ligase complex
  • G2/M transition of mitotic cell cycle
  • G1/S transition of mitotic cell cycle
  • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
  • protein ubiquitination during ubiquitin-dependent protein catabolic process
  • DNA replication origin binding
  • ubiquitin-protein ligase activity
  • protein binding, bridging
  • COF1
  • actin cortical patch
  • actin filament severing
  • actin filament depolymerization
  • actin filament organization
  • protein binding
  • CPR1
  • nucleus
  • mitochondrion
  • histone deacetylase complex
  • ascospore formation
  • protein metabolic process
  • peptidyl-prolyl cis-trans isomerase activity
  • FOL2
  • nucleus
  • cytoplasm
  • folic acid and derivative biosynthetic process
  • GTP cyclohydrolase I activity
  • GRR1
  • nucleus
  • cellular bud neck contractile ring
  • nuclear ubiquitin ligase complex
  • cytoplasm
  • SCF ubiquitin ligase complex
  • G1/S transition of mitotic cell cycle
  • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
  • response to DNA damage stimulus
  • cell cycle arrest in response to pheromone
  • protein ubiquitination
  • ubiquitin-protein ligase activity
  • protein binding
  • HTB2
  • nuclear nucleosome
  • chromatin assembly or disassembly
  • DNA binding
  • PDC5
  • nucleus
  • cytoplasm
  • cytosol
  • pyruvate metabolic process
  • glucose catabolic process to ethanol
  • pyruvate decarboxylase activity
  • PDC6
  • cytoplasm
  • ethanol metabolic process
  • pyruvate decarboxylase activity
  • PFK1
  • 6-phosphofructokinase complex
  • cytoplasm
  • mitochondrion
  • glycolysis
  • 6-phosphofructokinase activity
  • POR1
  • integral to mitochondrial outer membrane
  • mitochondrion
  • mitochondrial outer membrane
  • ion transport
  • aerobic respiration
  • mitochondrion organization
  • voltage-gated anion channel activity
  • SAH1
  • cytoplasm
  • methionine metabolic process
  • selenocysteine metabolic process
  • adenosylhomocysteinase activity
  • SKP1
  • RAVE complex
  • nucleus
  • cytoplasm
  • CBF3 complex
  • SCF ubiquitin ligase complex
  • kinetochore
  • G2/M transition of mitotic cell cycle
  • protein complex assembly
  • regulation of exit from mitosis
  • G1/S transition of mitotic cell cycle
  • cytokinesis
  • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
  • regulation of protein complex assembly
  • protein neddylation
  • kinetochore assembly
  • vacuolar acidification
  • protein ubiquitination during ubiquitin-dependent protein catabolic process
  • DNA replication origin binding
  • ubiquitin-protein ligase activity
  • protein binding
  • UBI4
  • cytoplasm
  • protein deubiquitination
  • ascospore formation
  • protein polyubiquitination
  • protein monoubiquitination
  • response to stress
  • protein ubiquitination
  • protein tag
  • ATP-dependent protein binding
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    SCF ubiquitin ligase complex 1.1264E-6 13 11 3 6292
    cullin-RING ubiquitin ligase complex 2.476E-6 13 14 3 6292
    ubiquitin ligase complex 8.1089E-5 13 43 3 6292
    6-phosphofructokinase complex 4.1283E-3 13 2 1 6292
    RAVE complex 6.1865E-3 13 3 1 6292
    CBF3 complex 8.2408E-3 13 4 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    SCF-dependent proteasomal ubiquitin-dependent protein catabolic process 2.4008E-7 13 7 3 6292
    protein ubiquitination 6.9177E-6 13 65 4 6292
    protein modification by small protein conjugation 2.1179E-5 13 86 4 6292
    protein modification by small protein conjugation or removal 6.4433E-5 13 114 4 6292
    G1/S transition of mitotic cell cycle 1.2771E-4 13 50 3 6292
    monohydric alcohol metabolic process 2.145E-4 13 11 2 6292
    ethanol metabolic process 2.145E-4 13 11 2 6292
    protein ubiquitination during ubiquitin-dependent protein catabolic process 2.145E-4 13 11 2 6292
    proteasomal protein catabolic process 3.3372E-4 13 69 3 6292
    proteasomal ubiquitin-dependent protein catabolic process 3.3372E-4 13 69 3 6292
    interphase of mitotic cell cycle 9.0814E-4 13 97 3 6292
    interphase 9.0814E-4 13 97 3 6292
    G2/M transition of mitotic cell cycle 1.5505E-3 13 29 2 6292
    selenocysteine metabolic process 2.0661E-3 13 1 1 6292
    actin filament severing 2.0661E-3 13 1 1 6292
    selenium metabolic process 2.0661E-3 13 1 1 6292
    catabolic process 2.253E-3 13 496 5 6292
    glucose catabolic process 3.5501E-3 13 44 2 6292
    modification-dependent protein catabolic process 3.5614E-3 13 156 3 6292
    ubiquitin-dependent protein catabolic process 3.5614E-3 13 156 3 6292
    proteolysis involved in cellular protein catabolic process 3.7586E-3 13 159 3 6292
    modification-dependent macromolecule catabolic process 4.1022E-3 13 164 3 6292
    hexose catabolic process 4.3876E-3 13 49 2 6292
    cellular protein catabolic process 4.6147E-3 13 171 3 6292
    post-translational protein modification 4.8383E-3 13 357 4 6292
    monosaccharide catabolic process 5.308E-3 13 54 2 6292
    alcohol catabolic process 5.8994E-3 13 57 2 6292
    proteolysis 6.0179E-3 13 188 3 6292
    protein catabolic process 6.1077E-3 13 189 3 6292
    centromere complex assembly 6.1865E-3 13 3 1 6292
    kinetochore assembly 6.1865E-3 13 3 1 6292
    kinetochore organization 6.1865E-3 13 3 1 6292
    generation of precursor metabolites and energy 6.663E-3 13 195 3 6292
    actin filament depolymerization 8.2408E-3 13 4 1 6292
    reproductive cellular process 8.2902E-3 13 211 3 6292
    reproductive process 8.399E-3 13 212 3 6292
    cellular carbohydrate catabolic process 9.2843E-3 13 72 2 6292
    alcohol metabolic process 9.301E-3 13 220 3 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    pyruvate decarboxylase activity 2.3591E-5 13 4 2 6292
    ubiquitin-protein ligase activity 1.8907E-4 13 57 3 6292
    small conjugating protein ligase activity 2.4292E-4 13 62 3 6292
    DNA replication origin binding 3.0349E-4 13 13 2 6292
    acid-amino acid ligase activity 3.6318E-4 13 71 3 6292
    carboxy-lyase activity 7.3325E-4 13 20 2 6292
    ligase activity, forming carbon-nitrogen bonds 8.2861E-4 13 94 3 6292
    carbon-carbon lyase activity 1.6593E-3 13 30 2 6292
    trialkylsulfonium hydrolase activity 2.0661E-3 13 1 1 6292
    GTP cyclohydrolase activity 2.0661E-3 13 1 1 6292
    GTP cyclohydrolase I activity 2.0661E-3 13 1 1 6292
    ATP-dependent protein binding 2.0661E-3 13 1 1 6292
    adenosylhomocysteinase activity 2.0661E-3 13 1 1 6292
    ligase activity 3.1865E-3 13 150 3 6292
    6-phosphofructokinase activity 4.1283E-3 13 2 1 6292
    sequence-specific DNA binding 4.5651E-3 13 50 2 6292
    protein binding 5.6775E-3 13 612 5 6292
    hydrolase activity, acting on ether bonds 6.1865E-3 13 3 1 6292
    voltage-gated anion channel activity 6.1865E-3 13 3 1 6292
    anion channel activity 6.1865E-3 13 3 1 6292

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