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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 8 proteins

Complex Member Proteins

Protein

 GO Cellular Component GO Biological Process GO Molecular Function
ASF1
  • chromatin assembly complex
    		•
  • histone acetylation
  • DNA replication-independent nucleosome assembly
  • chromatin silencing at silent mating-type cassette
  • nucleosome disassembly
  • chromatin silencing at telomere
  • DNA replication-dependent nucleosome assembly
    		•
  • histone binding
    		•
    HAT1
  • nucleus
  • cytoplasm
  • histone acetyltransferase complex
    		•
  • histone acetylation
  • chromatin silencing at telomere
    		•
  • histone binding
    		•
    HAT2
  • nucleus
  • cytoplasm
  • histone acetyltransferase complex
    		•
  • chromatin assembly or disassembly
  • histone acetylation
  • chromatin silencing at telomere
    		•
  • histone binding
    		•
    HHF1, HHF2
  • nucleus
  • nucleoplasm part
  • nuclear nucleosome
  • chromosome
  • replication fork protection complex
  • chromatin remodeling complex
  • nucleosome
  • histone acetyltransferase complex
  • nucleoplasm
    		•
  • histone H3-K79 methylation
  • DNA repair
  • negative regulation of transcription
  • chromatin assembly or disassembly
  • positive regulation of transcription
  • nucleosome assembly
    		•
  • DNA binding
    		•
    HHT1, HHT2
  • nucleus
  • nuclear nucleosome
  • chromosome
  • replication fork protection complex
  • nucleosome
    		•
  • mitotic cell cycle spindle assembly checkpoint
  • DNA repair
  • negative regulation of biosynthetic process
  • chromatin assembly or disassembly
  • positive regulation of transcription
  • response to DNA damage stimulus
  • aging
  • DNA packaging
  • nucleosome assembly
  • negative regulation of transposition, RNA-mediated
  • chromosome organization
  • negative regulation of transcription
  • negative regulation of transposition
  • regulation of transposition
  • regulation of transposition, RNA-mediated
    		•
  • DNA binding
    		•
    HIF1
  • nucleus
  • histone acetyltransferase complex
    		•
  • histone acetylation
  • chromatin silencing at telomere
  • nucleosome assembly
    		•
  • histone binding
    		•
    POB3
  • nucleus
  • FACT complex
  • nuclear chromatin
  • alpha DNA polymerase:primase complex
    		•
  • chromatin remodeling
  • DNA-dependent DNA replication
  • chromatin assembly or disassembly
  • transcription initiation from RNA polymerase II promoter
  • RNA elongation from RNA polymerase II promoter
    		•
  • chromatin binding
    		•
    PSH1
  • nucleus
    		•
  • RNA elongation from RNA polymerase II promoter
    		•
  • molecular_function
    		•

    Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    histone acetyltransferase complex 1.4271E-7 8 44 4 6292
    replication fork protection complex 1.4147E-6 8 2 2 6292
    nuclear replication fork 1.5229E-6 8 20 3 6292
    nucleoplasm part 4.3736E-6 8 245 5 6292
    nucleoplasm 6.3232E-6 8 264 5 6292
    replication fork 1.5136E-5 8 42 3 6292
    nuclear part 3.3951E-5 8 1103 7 6292
    protein-DNA complex 3.8233E-5 8 57 3 6292
    protein complex 4.178E-5 8 1137 7 6292
    nuclear chromatin 8.0492E-5 8 73 3 6292
    nuclear lumen 8.8346E-5 8 453 5 6292
    nuclear nucleosome 9.2781E-5 8 12 2 6292
    nucleosome 9.2781E-5 8 12 2 6292
    chromatin 9.4442E-5 8 77 3 6292
    nucleus 1.2145E-4 8 2041 8 6292
    macromolecular complex 4.9027E-4 8 1635 7 6292
    organelle lumen 5.3463E-4 8 660 5 6292
    intracellular organelle lumen 5.3463E-4 8 660 5 6292
    membrane-enclosed lumen 7.0576E-4 8 700 5 6292
    nuclear chromosome part 1.357E-3 8 190 3 6292
    nuclear chromosome 2.2974E-3 8 228 3 6292
    FACT complex 2.5415E-3 8 2 1 6292
    chromosomal part 2.5676E-3 8 237 3 6292
    chromosome 3.8858E-3 8 274 3 6292
    organelle part 4.4856E-3 8 2282 7 6292
    intracellular organelle part 4.4856E-3 8 2282 7 6292
    alpha DNA polymerase:primase complex 8.8705E-3 8 7 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    chromatin assembly or disassembly 5.2446E-13 8 35 6 6292
    chromatin organization 2.5589E-10 8 203 7 6292
    nucleosome assembly 1.9408E-9 8 16 4 6292
    transcription 3.3497E-9 8 552 8 6292
    chromatin assembly 4.127E-9 8 19 4 6292
    negative regulation of transcription 7.6813E-9 8 164 6 6292
    negative regulation of gene expression 7.6813E-9 8 164 6 6292
    chromatin modification 8.8861E-9 8 168 6 6292
    negative regulation of macromolecule biosynthetic process 1.1372E-8 8 175 6 6292
    negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 1.348E-8 8 180 6 6292
    negative regulation of nitrogen compound metabolic process 1.348E-8 8 180 6 6292
    negative regulation of biosynthetic process 1.8092E-8 8 189 6 6292
    negative regulation of cellular biosynthetic process 1.8092E-8 8 189 6 6292
    negative regulation of macromolecule metabolic process 1.9893E-8 8 192 6 6292
    nucleosome organization 2.516E-8 8 29 4 6292
    covalent chromatin modification 2.5866E-8 8 88 5 6292
    histone modification 2.5866E-8 8 88 5 6292
    negative regulation of cellular metabolic process 3.3152E-8 8 209 6 6292
    negative regulation of metabolic process 3.4118E-8 8 210 6 6292
    DNA packaging 3.8035E-8 8 32 4 6292
    histone acetylation 6.2178E-8 8 36 4 6292
    protein-DNA complex assembly 8.6688E-8 8 39 4 6292
    negative regulation of cellular process 9.7156E-8 8 250 6 6292
    negative regulation of biological process 1.0435E-7 8 253 6 6292
    protein amino acid acetylation 1.7137E-7 8 46 4 6292
    chromosome organization 2.9656E-7 8 555 7 6292
    chromatin silencing at telomere 3.5652E-7 8 55 4 6292
    DNA conformation change 4.4283E-7 8 58 4 6292
    protein amino acid acylation 4.7479E-7 8 59 4 6292
    regulation of transcription 1.2545E-6 8 384 6 6292
    cellular macromolecule biosynthetic process 1.5738E-6 8 1187 8 6292
    macromolecule biosynthetic process 1.5953E-6 8 1189 8 6292
    regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 1.9869E-6 8 415 6 6292
    regulation of nitrogen compound metabolic process 2.0153E-6 8 416 6 6292
    gene expression 2.9372E-6 8 1283 8 6292
    regulation of gene expression 3.0015E-6 8 445 6 6292
    regulation of macromolecule biosynthetic process 3.4669E-6 8 456 6 6292
    negative regulation of gene expression, epigenetic 4.0055E-6 8 100 4 6292
    gene silencing 4.0055E-6 8 100 4 6292
    regulation of gene expression, epigenetic 4.0055E-6 8 100 4 6292
    chromatin silencing 4.0055E-6 8 100 4 6292
    regulation of cellular biosynthetic process 4.2489E-6 8 472 6 6292
    regulation of biosynthetic process 4.3022E-6 8 473 6 6292
    regulation of macromolecule metabolic process 5.171E-6 8 488 6 6292
    transcription, DNA-dependent 6.1796E-6 8 503 6 6292
    nucleic acid metabolic process 6.4427E-6 8 1415 8 6292
    RNA biosynthetic process 6.5498E-6 8 508 6 6292
    regulation of primary metabolic process 7.018E-6 8 514 6 6292
    macromolecular complex assembly 8.5984E-6 8 281 5 6292
    regulation of cellular metabolic process 8.9774E-6 8 536 6 6292
    regulation of metabolic process 1.0114E-5 8 547 6 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 1.4527E-5 8 1566 8 6292
    cellular biosynthetic process 1.4602E-5 8 1567 8 6292
    biosynthetic process 1.7431E-5 8 1602 8 6292
    negative regulation of transcription, DNA-dependent 2.4161E-5 8 157 4 6292
    negative regulation of RNA metabolic process 2.4776E-5 8 158 4 6292
    macromolecular complex subunit organization 2.779E-5 8 357 5 6292
    post-translational protein modification 2.779E-5 8 357 5 6292
    cellular nitrogen compound metabolic process 3.8773E-5 8 1770 8 6292
    organelle organization 3.9333E-5 8 1127 7 6292
    cellular component assembly 4.0149E-5 8 385 5 6292
    nitrogen compound metabolic process 4.2618E-5 8 1791 8 6292
    cellular macromolecular complex assembly 4.33E-5 8 182 4 6292
    regulation of cellular process 8.9921E-5 8 796 6 6292
    regulation of biological process 1.0978E-4 8 824 6 6292
    protein modification process 1.4081E-4 8 499 5 6292
    cellular macromolecular complex subunit organization 1.7229E-4 8 259 4 6292
    RNA metabolic process 2.5461E-4 8 954 6 6292
    macromolecule modification 2.6414E-4 8 569 5 6292
    cellular macromolecule metabolic process 3.0018E-4 8 2285 8 6292
    macromolecule metabolic process 3.7455E-4 8 2349 8 6292
    cellular component organization 3.9282E-4 8 1582 7 6292
    regulation of transcription, DNA-dependent 6.0084E-4 8 358 4 6292
    regulation of RNA metabolic process 6.3358E-4 8 363 4 6292
    cellular component biogenesis 6.7771E-4 8 694 5 6292
    biological regulation 9.9402E-4 8 1213 6 6292
    RNA elongation from RNA polymerase II promoter 1.0239E-3 8 39 2 6292
    nucleosome disassembly 1.2715E-3 8 1 1 6292
    DNA replication-dependent nucleosome assembly 1.2715E-3 8 1 1 6292
    histone H3-K79 methylation 1.2715E-3 8 1 1 6292
    DNA replication-dependent nucleosome organization 1.2715E-3 8 1 1 6292
    negative regulation of transposition, RNA-mediated 1.2715E-3 8 1 1 6292
    regulation of transposition, RNA-mediated 1.2715E-3 8 1 1 6292
    chromatin disassembly 1.2715E-3 8 1 1 6292
    protein-DNA complex disassembly 1.2715E-3 8 1 1 6292
    RNA elongation 1.3628E-3 8 45 2 6292
    primary metabolic process 2.0036E-3 8 2896 8 6292
    histone lysine methylation 2.5415E-3 8 2 1 6292
    cellular metabolic process 2.9013E-3 8 3033 8 6292
    metabolic process 3.9991E-3 8 3157 8 6292
    cellular protein metabolic process 5.103E-3 8 1074 5 6292
    protein metabolic process 6.5695E-3 8 1136 5 6292
    DNA replication-independent nucleosome assembly 7.6075E-3 8 6 1 6292
    DNA replication-independent nucleosome organization 7.6075E-3 8 6 1 6292
    positive regulation of transcription 8.1985E-3 8 112 2 6292
    positive regulation of gene expression 8.1985E-3 8 112 2 6292
    positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 9.0698E-3 8 118 2 6292
    positive regulation of nitrogen compound metabolic process 9.0698E-3 8 118 2 6292
    positive regulation of macromolecule biosynthetic process 9.0698E-3 8 118 2 6292
    positive regulation of biosynthetic process 9.5206E-3 8 121 2 6292
    positive regulation of cellular biosynthetic process 9.5206E-3 8 121 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    histone binding 1.0685E-9 8 14 4 6292
    binding 1.0087E-4 8 1294 7 6292
    protein binding 4.508E-3 8 612 4 6292
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle