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Protein Overview: RPF1

General Information:
Name(s) found: RPF1 / YHR088W [SGD]
Description(s) found:
Found 28 descriptions.
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  • Nucleolar protein involved in the assembly and export of the large ribosomal subunit; constituent of 66S pre-ribosomal particles; contains a sigma(70)-like motif, which is thought to bind RNA [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 295 amino acids

    Gene Ontology:
    Cellular Component: nucleolus [IDALink to PubMed article][IPILink to PubMed article]
    Biological Process: ribosome biogenesis [RCALink to PubMed article]
    ribosomal large subunit assembly [IPILink to PubMed article]
    processing of 27S pre-rRNA [IMPLink to PubMed article]
    Molecular Function: rRNA primary transcript binding [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALGNEINIT NKLKRQEIFA DIKHEKNKER HTMRRKRAKE ERENPELREQ RLKENVTQTI  60
   61 ENTRVYDETI NKEVEGDEDD LMRYFNSNSN EPPKIFLTTN VNAKKSAYEF ANILIEILPN 120
  121 VTFVKRKFGY KLKEISDICI KRNFTDIVII NEDKKKVTGL TFIHLPEGPT FYFKLSSFVE 180
  181 VKKIVGHGRP TSHIPELILN NFQTRLGQTV GRLFQSILPQ NPDIEGRQVI TLHNQRDYIF 240
  241 FRRHRYVFKD NERVGLQELG PQFTLKLKRL QRGIKEETEW EHKPEMDKEK KKFYL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) BRX1 CIC1 DBP10 DRS1 ERB1 FPR4 HAS1 IPI3 LOC1 MAK21 MAK5 MRT4 NIP7 NOC2 NOC3 NOG1 NOP15 NOP2 NOP4 NOP7 NSA1 NSA2 NUG1 PUF6 RIX1 RIX7 RLP7 RPF1 RPL25 SDA1 SPB4 TIF6 URB1 YTM1
    View Details Gavin AC, et al. (2006) NSA1 RPF1
    View Details Gavin AC, et al. (2002) ARX1 BEM2 BMS1 BRX1 BUD20 CIC1 CLU1 CYR1 CYS4 DBP10 DBP9 DCP2 DRS1 EBP2 ERB1 FPR4 GCN1 HAS1 HDA1 HER1 HIS3 INP2 IPI1 IPI3 KRE33 LHP1 LOC1 LSG1 MAK21 MAK5 MDN1 MIS1 MRT4 NAP1 NIP1 NIP7 NMD3 NOC2 NOC3 NOG1 NOG2 NOP1 NOP12 NOP15 NOP16 NOP2 NOP4 NOP56 NOP7 NSA1 NSA2 NUG1 PRT1 PUF6 REI1 RIX1 RIX7 RLP24 RLP7 RPA135 RPA190 RPF1 RPF2 RPG1 RPP2B RPT6 RRP1 RRP12 RSA3 RSA4 RTR1 SDA1 SEC7 SKI2 SNU13 SPB1 SPB4 SSF1 TIF6 TUB3 URB1 UTP10 UTP20 UTP22 YGL036W YTM1
    View Details Ho Y, et al. (2002) CIC1 ERB1 RPF1 SRP54 TMA108 VPS35 YBR242W YPD1 YTM1
    View Details Qiu et al. (2008) BRX1 NOP53 RLP7 RPF1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..93] deduced N/A No confident structure predictions are available.
    2 View Details [94..295] Pfam 35.275724 No description for PF01945 was found. No confident structure predictions are available.
    3 View Details [185..295] FFAS03 1.61 Crystal structure of probable ribosomal biogenesis protein from Aeropyrum pernix K1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • aminoacyl-tRNA ligase activity
    		•  3.58650371779212 bayes_pls_golite062009
  • ligase activity, forming carbon-oxygen bonds
    		•  3.58624422951947 bayes_pls_golite062009
  • ligase activity, forming aminoacyl-tRNA and related compounds
    		•  3.58624422951947 bayes_pls_golite062009
  • ligase activity
    		•  2.44518871945794 bayes_pls_golite062009
  • proline-tRNA ligase activity
    		•  2.35871952544841 bayes_pls_golite062009
  • binding
    		•  1.78917266819015 bayes_pls_golite062009
  • catalytic activity
    		•  0.902495165806215 bayes_pls_golite062009
  • protein binding
    		•  0.665778090365515 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle