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Protein Overview: CAM1

General Information:
Name(s) found: CAM1 / YPL048W [SGD]
Description(s) found:
Found 31 descriptions.
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  • Nuclear protein required for transcription of MXR1; binds the MXR1 promoter in the presence of other nuclear factors; binds calcium and phospholipids; has similarity to translational cofactor EF-1 gamma [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 415 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA][IEA]
    cytoplasm [IEA]
    eukaryotic translation elongation factor 1 complex [IEA]
    Biological Process: regulation of translational elongation [IGILink to PubMed article][ISSLink to PubMed article]
    Molecular Function: translation elongation factor activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQGTLYANF RIRTWVPRGL VKALKLDVKV VTPDAAAEQF ARDFPLKKVP AFVGPKGYKL  60
   61 TEAMAINYYL VKLSQDDKMK TQLLGADDDL NAQAQIIRWQ SLANSDLCIQ IANTIVPLKG 120
  121 GAPYNKKSVD SAMDAVDKIV DIFENRLKNY TYLATENISL ADLVAASIFT RYFESLFGTE 180
  181 WRAQHPAIVR WFNTVRASPF LKDEYKDFKF ADKPLSPPQK KKEKKAPAAA PAASKKKEEA 240
  241 KPAATETETS SKKPKHPLEL LGKSTFVLDD WKRKYSNEDT RPVALPWFWE HYNPEEYSLW 300
  301 KVTYKYNDEL TLTFMSNNLV GGFFNRLSAS TKYMFGCLVV YGENNNNGIV GAVMVRGQDY 360
  361 VPAFDVAPDW ESYDYAKLDP TNDDDKEFIN NMWAWDKPVS VNGEPKEIVD GKVLK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CAM1 EFB1 FBA1 HSC82 HSP104 RPS0A SSZ1 TEF4 YEF3 ZUO1
    View Details (MIPS) Mewes HW, et al. (2004) CAM1 EFB1 HBS1 TEF1, TEF2 TEF4
    View Details Krogan NJ, et al. (2006) ARO4 CAM1 TEF4 TMA19
    View Details Gavin AC, et al. (2006) CAM1 EFB1 HSL1 RAD34 TEF1, TEF2
    View Details Gavin AC, et al. (2002) CAM1 EFB1 FAP1 GFA1 GUS1 ILV1 KAP123 MGA2 NEW1 OLA1 SBP1 SEC27 TEF1, TEF2 TEF4
    View Details Qiu et al. (2008) CAM1 TEF1, TEF2 TEF4 TIF5

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run BOI1 Sample boi 1 with ha tag from october 2005 McCusker D, et al (2007)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen GPA1 CAM1 1 Unpublished Fields Lab Data
    View Screen SPT21 CAM1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data CAM1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..223] PSI-BLAST 40.69897 GST-like domain of elongation factor 1-gamma
    2 View Details [224..415] PSI-BLAST 77.0 Elongation factor 1-gamma C-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  2.30799114442278 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.06381591939564 bayes_pls_golite062009
  • DNA binding
    		•  1.92118545500784 bayes_pls_golite062009
  • binding
    		•  1.25802922431343 bayes_pls_golite062009
  • transcription activator activity
    		•  1.23146660729357 bayes_pls_golite062009
  • protein binding
    		•  1.18479617596618 bayes_pls_golite062009
  • catalytic activity
    		•  0.672192331361968 bayes_pls_golite062009
  • RNA binding
    		•  0.382017633056715 bayes_pls_golite062009
    		• 0.359224524631956 bayes_pls_golite062009
  • receptor binding
    		•  0.0497559408754589 bayes_pls_golite062009
    2
    Term Confidence Notes
  • translation elongation factor activity
    		•  11.9602302019768 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  7.4644014407268 bayes_pls_golite062009
  • translation regulator activity
    		•  7.42485540728491 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.9329721501879 bayes_pls_golite062009
  • binding
    		•  3.0325775548747 bayes_pls_golite062009
  • protein binding
    		•  1.65598815428763 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle