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Protein Overview: ERG10

General Information:
Name(s) found: ERG10 / YPL028W [SGD]
Description(s) found:
Found 28 descriptions.
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  • Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase), cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 398 amino acids

    Gene Ontology:
    Cellular Component: cytosol [TAS]
    Biological Process: ergosterol biosynthetic process [TAS]
    Molecular Function: acetyl-CoA C-acetyltransferase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQNVYIVST ARTPIGSFQG SLSSKTAVEL GAVALKGALA KVPELDASKD FDEIIFGNVL  60
   61 SANLGQAPAR QVALAAGLSN HIVASTVNKV CASAMKAIIL GAQSIKCGNA DVVVAGGCES 120
  121 MTNAPYYMPA ARAGAKFGQT VLVDGVERDG LNDAYDGLAM GVHAEKCARD WDITREQQDN 180
  181 FAIESYQKSQ KSQKEGKFDN EIVPVTIKGF RGKPDTQVTK DEEPARLHVE KLRSARTVFQ 240
  241 KENGTVTAAN ASPINDGAAA VILVSEKVLK EKNLKPLAII KGWGEAAHQP ADFTWAPSLA 300
  301 VPKALKHAGI EDINSVDYFE FNEAFSVVGL VNTKILKLDP SKVNVYGGAV ALGHPLGCSG 360
  361 ARVVVTLLSI LQQEGGKIGV AAICNGGGGA SSIVIEKI

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ERG10 LEU1 MSM1
    View Details Ho Y, et al. (2002) AAT2 ACS2 ADE3 ADE6 ADH4 ADO1 ALA1 APE2 ARA1 ARG4 BAT1 CAR2 CDC10 CDC60 CLU1 CPR1 CYS3 DED81 DLD3 DPS1 DUG1 ENP1 ERG10 ERG20 FUM1 GCY1 GPH1 GRS1 HOM2 HSV2 HYP2 ILS1 ILV3 IMD3 KRS1 LSP1 MDH3 MPC54 NAS6 OLA1 PAB1 PDC5 PFK2 PGM2 PMI40 PRP6 RHO1 SAC6 SCP160 SKS1 SOD1 SSZ1 SUI1 THR4 TPS1 TRR1 UBA1 WTM1 YDL124W

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen SXM1 ERG10 2 Unpublished Fields Lab Data
    View Screen LOS1 ERG10 2 Unpublished Fields Lab Data
    View Screen PSE1 ERG10 1 Unpublished Fields Lab Data
    View Screen APC5 ERG10 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data ERG10 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..151]
    [198..222]
    [254..282]
    [353..368]    		 PSI-BLAST 861.457575 Biosynthetic thiolase
    2 View Details [152..197]
    [223..253]
    [283..352]
    [369..398]    		 PSI-BLAST 861.457575 Biosynthetic thiolase


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.84

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle