Protein Overview: SGO1

General Information:
Name(s) found:	SGO1 / YOR073W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|74583719\|sp\|Q08490.1\|SGO1_YEAST RecName: Full=Shugoshin [NCBI NR] gi\|6324647\|ref\|NP_014716.1\| Component of the spindle checkpoint, involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome st [NCBI NR] pir\|\|S66956 hypothetical protein YOR073w - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|2104885\|emb\|CAA94558.1\| YOR29-24 [Saccharomyces cerevisiae] [NCBI NR] gi\|1420227\|emb\|CAA99266.1\| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR] Shugoshin OS=Saccharomyces cerevisiae GN=SGO1 PE=1 SV=1 [Swiss-Prot] SGO1 Protein required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability [mips] Component of the spindle checkpoint, involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability [SGD] >Q08490 (Q08490) Chromosome XV reading frame ORF YOR073W [4932.FASTACCERV.txt] Chr XV from 464772-466544 [hmr_yeast5_DM3-1_pombe.fasta] YOR073W, Chr XV from 464772-466544 [yeast_orfs2] SGO1 SGDID:S0005599, Chr XV from 464772-466544, Verified ORF [yeastflysequest.fasta] Protein that protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability; evolutionarily conserved, with similarity to S. pombe Sgo1 and Drosophila MEI-S332 [Saccharomyces cerev [nrdb_11152004_Chlamydomonas] (Q08490) S.cerevisiae chromosome XV reading frame ORF YOR073w (YOR29-24 protein) [cerv4932.FASTAC] SGO1 SGDID:S000005599, Chr XV from 464772-466544, Verified ORF, "Component of the spindle checkpoint, involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at mei [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] SGO1 SGDID:S000005599, Chr XV from 464773-466545, Verified ORF, "Component of the spindle checkpoint, involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at mei [yeast-contam.fasta] YOR29-24 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Shugoshin [nr-271106-contam.fasta] Component of the spindle checkpoint, involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability; Sgo1p [Saccharomyce [nr-271106-contam.fasta] SGO1 SGDID:S000005599, Chr XV from 464773-466545, Verified ORF, "Component of the spindle checkpoint, involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability" [yeast-bovrabprots.fasta] [chemostatdb.fasta] Shugoshin OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SGO1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] SGO1 SGDID:S000005599, Chr XV from 464771-466543, Genome Release 64-1-1, Verified ORF, "Component of the spindle checkpoint, involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability" [yeast-030211-contam.fasta] SGO1 SGDID:S000005599, Chr XV from 464771-466543, Genome Release 64-2-1, Verified ORF, "Component of the spindle checkpoint; involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability; recruits condensin to the pericentric region of chromosomes during meiosis; dissociates from pericentromeres when sister kinetochores are under tension" [20141208_orf_trans.fasta] YOR073W SGDID:S000005599, Chr XV from 464771-466543, Genome Release 64-1-1, Verified ORF, "Component of the spindle checkpoint, involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	590 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA] spindle pole body [IDA] kinetochore [IDA] chromosome, centromeric region [IDA]
Biological Process:	mitotic cell cycle spindle assembly checkpoint [IGI][IMP] meiotic sister chromatid segregation [IGI][IMP ] mitotic sister chromatid segregation [IGI][IMP ]
Molecular Function:	molecular_function [ND]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPKRKIAPNK ESSRRTVSHD DLTPQIQEFQ NLMDLESQKV ENIRQSYSRQ NSLLAKDNSI  60
   61 LKIKVNSLEK KISQLVQENV TLRSKTSISE AIYRERLSNQ LQVIENGIIQ RFDEIFYMFE 120
  121 NVRKNENLPS SSLRTMLKRT SSRSRSCSLS SPTYSKSYTR LSNHENNLSH ESSFNKDDGP 180
  181 DLEPKAKKRK SSRRQSMFVS TSLEPEDETG ENEPMMENSS VEVPAESHES AQVEETIDAL 240
  241 NPEEENSDSV SNFTNSIIEY SIPEENPTEP EHSSSKLEIF NDSTNMLSTV PSNPLPLPLP 300
  301 GPSATLPTTT SDASTVYPSS SSSTNSHPKT KIKHSMKPPR IELKKKVIDE VMPVSNMSSN 360
  361 SEISFTRTRR TRGKAVDYTL PSLRAKMRRP SEKLVDATTV IDIHDLQVSK RNRETSHKRK 420
  421 SLSQDSIPDE PQLREVVVSK DYGTPKGKKT EDEIHEDTAH LMTTSNNNSN NKNEKKLTSN 480
  481 NSPKKSSPLL DITNKSENKK KSTRTKKLFK NAIVNNLSDE NSTTRPSKSS KGTSNNNNNY 540
  541 NNFDNNNSNI NNVNNKSVSF RLNEDDLAVF DLFGNGKAVK HQPKTYRTKK

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Ho Y, et al. (2002)		AAC3 BUD32 CAR2 CPR6 CRM1 DIA4 GRX3 GRX4 HEF3 IDP2 IMD2 IMD4 KAE1 NPA3 PHO81 RNH202 RPN1 RPN5 RPN6 RPT1 SEC18 SEC23 SGO1 TMA29 URA7 YHR033W
View Details	Qiu et al. (2008)		BBP1 BFA1 BUB3 CDC14 CSM1 HSK3 KAR3 KAR9 MAD2 SGO1 STU1 STU2

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	MLP2	#25 Asynchronous Prep3-TiO2 Flowthrough	Keck JM, et al. (2011)
View Run	MLP2	#32 Asynchronous Prep-No Phosphopeptide enrichment	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

	PROTEIN(S)	PUBLICATION
View Data	SGO1	Huh WK, et al. (2003)
View Data	SGO1 and SPC42	Huh WK, et al. (2003)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..410]	MSA	1.002894	View MSA. No confident structure predictions are available.
2	View Details	[411..590]	deduced	N/A	No confident structure predictions are available.
3	View Details	[449..590]	deduced	N/A	No confident structure predictions are available.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: SGO1

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: