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Protein Overview: RRI2

General Information:
Name(s) found: RRI2 / YOL117W [SGD]
Description(s) found:
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  • gi|74627277|sp|Q12348.1|CSN10_YEAST RecName: Full=COP9 signalosome complex subunit 10 [NCBI NR]
  • gi|663235|emb|CAA88143.1| orf [Saccharomyces cerevisiae] [NCBI NR]
  • gi|6324455|ref|NP_014524.1| Subunit of the COP9 signalosome (CSN) complex that cleaves the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; plays a role in the mating pheromone response; Rri2p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1419991|emb|CAA99136.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S51880 probable membrane protein YOL117w - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • COP9 signalosome complex subunit 10 OS=Saccharomyces cerevisiae GN=RRI2 PE=1 SV=1 [Swiss-Prot]
  • RRI2 COP9 signalosome (CSN) subunit [mips]
  • Subunit of the COP9 signalosome (CSN) complex that cleaves the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; plays a role in the mating pheromone response [SGD]
  • >Q12348 (Q12348) Chromosome XV reading frame ORF YOL117W [4932.FASTACCERV.txt]
  • Chr XV from 97550-99487 [hmr_yeast5_DM3-1_pombe.fasta]
  • YOL117W, Chr XV from 97550-99487 [yeast_orfs2]
  • RRI2 SGDID:S0005477, Chr XV from 97550-99487, Verified ORF [yeastflysequest.fasta]
  • Rri2p [Saccharomyces cerevisiae]gi|663235|emb|CAA88143.1| orf [Saccharomyces cerevisiae]gi|1419991|emb|CAA99136.1| unnamed protein product [Saccharomyces cerevisiae]gi|1077299|pir||S51880 probable membrane protein YOL117w - yeast (Saccharomyces cerevis [nrdb_11152004_Chlamydomonas]
  • (Q12348) S.cerevisiae chromosome XV reading frame ORF YOL117w (Orf protein) [cerv4932.FASTAC]
  • RRI2 SGDID:S000005477, Chr XV from 97550-99487, Verified ORF, "Subunit of the COP9 signalosome (CSN) complex that cleaves the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; plays a role in the mating pheromone response" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • RRI2 SGDID:S000005477, Chr XV from 97551-99488, Verified ORF, "Subunit of the COP9 signalosome (CSN) complex that cleaves the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; plays a role in the mating pheromone response" [yeast-contam.fasta]
  • Subunit of the COP9 signalosome (CSN) complex that cleaves the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; plays a role in the mating pheromone response; Rri2p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • COP9 signalosome complex subunit 10 [nr-271106-contam.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • orf [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • COP9 signalosome complex subunit 10 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RRI2 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • RRI2 SGDID:S000005477, Chr XV from 97551-99488, Genome Release 64-1-1, Verified ORF, "Subunit of the COP9 signalosome (CSN) complex that cleaves the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; plays a role in the mating pheromone response" [yeast-030211-contam.fasta]
  • RRI2 SGDID:S000005477, Chr XV from 97551-99488, Genome Release 64-2-1, Verified ORF, "Subunit of the COP9 signalosome (CSN) complex; this complex cleaves the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; plays a role in the mating pheromone response" [20141208_orf_trans.fasta]
  • YOL117W SGDID:S000005477, Chr XV from 97551-99488, Genome Release 64-1-1, Verified ORF, "Subunit of the COP9 signalosome (CSN) complex that cleaves the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; plays a role in the mating pheromone response" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 645 amino acids

    Gene Ontology:
    Cellular Component: signalosome [IDALink to PubMed article][TASLink to PubMed article]
    Biological Process: protein deneddylation [IMPLink to PubMed articleLink to PubMed article]
    adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion [IGILink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDEDNNYDD FMLSDDEGME SIEMEEETDD EDKQNIEINE DNSQDDQDRG AARHKQHEQG  60
   61 TFEKHDRVED ICERIFEQGQ ALKEDERYKE ARDLFLKIYY KEEFSSDESI ERLMTWKFKS 120
  121 LIEILRLRAL QLYFQKNGAQ DLVLQILEDT ATMSVFLQRI DFQIDGNIFE LLSDTFEVLA 180
  181 PKWERVFLFD IEKVDRENMI CKIDFQKNFM DQFQWILRKP GKDCKLQNLQ RIIRKKIFIA 240
  241 VVWYQRLTMG NVFTPEISSQ IEILVKDNEC SSFEENNDLE SVSMLLQYYI LEYMNTARIN 300
  301 NRRLFKKCID FFEMLISKSL TFSQESGLMV ILYTSKIVFI LDSDSENDLS FALMRYYDRK 360
  361 EELKNMFLYI LKHLEEMGKL RERDITSLFH KFILSGFIFT SMILEAISTD KINPFGFEQV 420
  421 KIALGSPIVN VLEDVYRCFA QLELRQLNAS ISLIPELSVV LSGIIQDIYY LAQTLKLWRK 480
  481 IARLYSCISI SDIISMLQIS DDNEMTRDDL LTILMRSIMK NRSVVYFKLD LTSDLVYFGD 540
  541 ENKVMLPRCS KEEFRLMISP KDEETTEKAR LIDFEYVNDV AIYNNPTRIR TKSSKEFFNT 600
  601 LRKSRETVKL PRVSNQSNED TFLPSYMKFS NKYLELCKLA SNNLE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CSI1 CSN9 PCI8 RPN5 RRI1 RRI2
    View Details Krogan NJ, et al. (2006) CSI1 CSN9 ERV46 FPR2 HUL5 IQG1 MOT1 MPT5 NAS6 NMD3 NPT1 PCI8 PEP1 PST1 PUS9 RPN1 RPN10 RPN11 RPN12 RPN13 RPN14 RPN2 RPN5 RPN6 RPN7 RPN8 RPN9 RPT1 RPT2 RPT3 RPT4 RPT5 RPT6 RRI1 RRI2 SEC18 SEM1 SKP1 SPG5 SPO77 SQT1 SWA2 TCB2 TIP41 TOD6 TOR2 TSR4 UBP6 YEN1 YKL027W YMR258C YNL022C YPR003C YPT52
    View Details Gavin AC, et al. (2006) CSI1 CSN9 PCI8 RRI1 RRI2
    View Details Gavin AC, et al. (2002) CSI1 CSN9 PCI8 RPN5 RRI1 RRI2
    View Details Qiu et al. (2008) CSI1 CSN12 PCI8 RRI1 RRI2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run BOI1 Sample boi1 with gst from october 2005 McCusker D, et al (2007)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data RRI2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..275] deduced N/A No confident structure predictions are available.
    2 View Details [276..560] ORFEUS 8.19 Hemolysin E (HlyE, ClyA, SheA)
    3 View Details [561..645] deduced N/A No confident structure predictions are available.
    4 View Details [414..559] FFAS03 1.38 Solution structure of the PCI domain
    5 View Details [560..645] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • transcription regulator activity
    		•  3.45730892915196 bayes_pls_golite062009
  • binding
    		•  3.37660003833383 bayes_pls_golite062009
  • DNA binding
    		•  3.14200456972385 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.10521633426493 bayes_pls_golite062009
  • transcription factor activity
    		•  2.53044123488453 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.13838000453063 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  1.28416365596732 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.21263034180893 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  1.12766532785895 bayes_pls_golite062009
  • transcription activator activity
    		•  1.04520012516585 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  0.761838897494019 bayes_pls_golite062009
  • protein binding
    		•  0.726445167461826 bayes_pls_golite062009
  • transcription factor binding
    		•  0.534573074451495 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  0.49516964123412 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.224432853777564 bayes_pls_golite062009
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.69

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle