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Protein Overview: URE2

General Information:
Name(s) found: URE2 / YNL229C [SGD]
Description(s) found:
Found 55 descriptions.
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  • Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 354 amino acids

    Gene Ontology:
    Cellular Component: soluble fraction [IDALink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: response to aluminum ion [IMPLink to PubMed article]
    telomere maintenance [IMPLink to PubMed article]
    regulation of nitrogen utilization [IGILink to PubMed article][IMPLink to PubMed article][IPILink to PubMed article]
    protein urmylation [IMPLink to PubMed article]
    cytoplasmic sequestering of transcription factor [IMPLink to PubMed article]
    Molecular Function: transcription corepressor activity [IGILink to PubMed article][IPILink to PubMed article]
    phosphoprotein binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMNNNGNQVS NLSNALRQVN IGNRNSNTTT DQSNINFEFS TGVNNNNNNN SSSNNNNVQN  60
   61 NNSGRNGSQN NDNENNIKNT LEQHRQQQQA FSDMSHVEYS RITKFFQEQP LEGYTLFSHR 120
  121 SAPNGFKVAI VLSELGFHYN TIFLDFNLGE HRAPEFVSVN PNARVPALID HGMDNLSIWE 180
  181 SGAILLHLVN KYYKETGNPL LWSDDLADQS QINAWLFFQT SGHAPMIGQA LHFRYFHSQK 240
  241 IASAVERYTD EVRRVYGVVE MALAERREAL VMELDTENAA AYSAGTTPMS QSRFFDYPVW 300
  301 LVGDKLTIAD LAFVPWNNVV DRIGINIKIE FPEVYKWTKH MMRRPAVIKA LRGE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) GLN3 MET4 URE2
    View Details Ho Y, et al. (2002) ACC1 AHA1 ARO4 CDC28 CDC60 CEG1 CKA1 CKA2 CKB1 CKB2 FKH1 FYV8 GCD2 GCD7 GCN3 HHF1, HHF2 HTB1 ILS1 MBP1 MGM101 MPH1 NET1 NOP1 RPA135 RPA190 RPC40 RRP1 SEC2 SIN3 SMC4 SUI2 SUI3 TRP5 UBP12 URE2 VMA4 YGR017W YMR144W

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen TRM82 URE2 2 Unpublished Fields Lab Data
    View Screen YJU2 URE2 2 Uetz P, et al. (2000)
    View Screen PML1 URE2 2 Unpublished Fields Lab Data
    View Screen EST1 URE2 2 Uetz P, et al. (2000)
    View Screen GBP2 URE2 1 Unpublished Fields Lab Data
    View Screen BRP1 URE2 1 Unpublished Fields Lab Data
    View Screen RAD6 URE2 1 Unpublished Fields Lab Data
    View Screen KSS1 URE2 1 Unpublished Fields Lab Data
    View Screen CDC23 URE2 1 Unpublished Fields Lab Data
    View Screen SDP1 URE2 1 Unpublished Fields Lab Data
    View Screen LIA1 URE2 1 Unpublished Fields Lab Data
    View Screen PUT1 URE2 1 Unpublished Fields Lab Data
    View Screen CTF13 URE2 1 Unpublished Fields Lab Data
    View Screen YKU80 URE2 1 Unpublished Fields Lab Data
    View Screen FUN19 URE2 1 Unpublished Fields Lab Data
    View Screen PFS2 URE2 1 Unpublished Fields Lab Data
    View Screen ERV46 URE2 1 Unpublished Fields Lab Data
    View Screen SPO21 URE2 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data URE2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..91] MSA 1.066984 View MSA. No confident structure predictions are available.
    2 View Details [92..199]
    [347..354]    		 PSI-BLAST 1625.39794 Yeast prion protein ure2p, nitrogen regulation fragment
    3 View Details [200..346] PSI-BLAST 1625.39794 Yeast prion protein ure2p, nitrogen regulation fragment

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • antioxidant activity
    		•  3.66884588063322 bayes_pls_golite062009
  • peroxidase activity
    		•  3.43831566988273 bayes_pls_golite062009
  • oxidoreductase activity, acting on peroxide as acceptor
    		•  3.43831566988273 bayes_pls_golite062009
  • glutathione binding
    		•  3.12157603958172 bayes_pls_golite062009
  • selenium binding
    		•  2.6356580403901 bayes_pls_golite062009
  • glutathione peroxidase activity
    		•  2.56524997297011 bayes_pls_golite062009
  • peroxiredoxin activity
    		•  2.12777217096121 bayes_pls_golite062009
  • thioredoxin peroxidase activity
    		•  1.96134566495756 bayes_pls_golite062009
  • glutathione transferase activity
    		•  1.85683051472829 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors
    		•  1.8187537496904 bayes_pls_golite062009
  • protein disulfide oxidoreductase activity
    		•  1.47769936616412 bayes_pls_golite062009
  • disulfide oxidoreductase activity
    		•  1.32811008894503 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.27179487791083 bayes_pls_golite062009
  • binding
    		•  1.25802922431343 bayes_pls_golite062009
  • phospholipid-hydroperoxide glutathione peroxidase activity
    		•  0.874146425427531 bayes_pls_golite062009
  • catalytic activity
    		•  0.672192331361968 bayes_pls_golite062009
  • transferase activity
    		•  0.245320538630117 bayes_pls_golite062009
  • protein binding
    		•  0.134341907247724 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle