Protein Overview: ATM1

General Information:
Name(s) found:	ATM1 / YMR301C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|798943\|emb\|CAA89134.1\| Atm1p [Saccharomyces cerevisiae] [NCBI NR] gi\|793877\|emb\|CAA57359.1\| MDYp [Saccharomyces cerevisiae] [NCBI NR] gi\|6323959\|ref\|NP_014030.1\| Mitochondrial inner membrane ATP-binding cassette (ABC) transporter, exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol; Atm1p [Saccharomyces cerevisiae] [NCBI NR] gi\|1352002\|sp\|P40416.2\|ATM1_YEAST RecName: Full=Iron-sulfur clusters transporter ATM1, mitochondrial; Flags: Precursor [NCBI NR] pir\|\|S54211 ATM1 protein precursor - yeast (Saccharomyces cerevisiae) [NCBI NR] Iron-sulfur clusters transporter ATM1, mitochondrial OS=Saccharomyces cerevisiae GN=ATM1 PE=1 SV=2 [Swiss-Prot] ATM1 Mitochondrial inner membrane, `half-size` ABC transporter involved in the maturation of cytosolic iron-sulfur (Fe/S) cluster-containing proteins [mips] Mitochondrial inner membrane ATP-binding cassette (ABC) transporter, exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol [SGD] ATM1, Chr XIII from 867555-869627, reverse complement [yeast_orfs2] Chr XIII from 867555-869627, reverse complement [yeastorf3.fasta] Chr XIII from 869627-867555, reverse complement [yeastorf5.fasta] (P40416) Transporter ATM1, mitochondrial precursor [4932.FASTACCERV.txt] ATM1 SGDID:S0004916, Chr XIII from 869626-867554, reverse complement, Verified ORF [yeastflysequest.fasta] Atm1p [Saccharomyces cerevisiae]gi\|798943\|emb\|CAA89134.1\| Atm1p [Saccharomyces cerevisiae]gi\|793877\|emb\|CAA57359.1\| MDYp [Saccharomyces cerevisiae]gi\|1352002\|sp\|P40416\|ATM1_YEAST Transporter ATM1, mitochondrial precursorgi\|1078103\|pir\|\|S54211 ATM1 pro [nrdb_11152004_Chlamydomonas] ATM1 SGDID:S000004916, Chr XIII from 869626-867554, reverse complement, Verified ORF, "Mitochondrial inner membrane transporter, exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol; member of the ATP-binding casset [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] ATM1 SGDID:S000004916, Chr XIII from 869626-867554, reverse complement, Verified ORF, "Mitochondrial inner membrane ATP-binding cassette (ABC) transporter, exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol" [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta] Atm1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] MDYp [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Mitochondrial inner membrane transporter, exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol; member of the ATP-binding cassette (ABC) transporter family; Atm1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Transporter ATM1, mitochondrial precursor [nr-271106-contam.fasta] ATM1 SGDID:S000004916, Chr XIII from 869626-867554, reverse complement, Verified ORF, "Mitochondrial inner membrane transporter, exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol; member of the ATP-binding cassette (ABC) transporter family" [yeast-contam_custom.fasta] [chemostatdb.fasta] Iron-sulfur clusters transporter ATM1, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ATM1 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] ATM1 SGDID:S000004916, Chr XIII from 869627-867555, Genome Release 64-1-1, reverse complement, Verified ORF, "Mitochondrial inner membrane ATP-binding cassette (ABC) transporter, exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol" [yeast-030211-contam.fasta] ATM1 SGDID:S000004916, Chr XIII from 869627-867555, Genome Release 64-2-1, reverse complement, Verified ORF, "Mitochondrial inner membrane ATP-binding cassette (ABC) transporter; exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol" [20141208_orf_trans.fasta] YMR301C SGDID:S000004916, Chr XIII from 869627-867555, Genome Release 64-1-1, reverse complement, Verified ORF, "Mitochondrial inner membrane ATP-binding cassette (ABC) transporter, exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	690 amino acids
Gene Ontology:
Cellular Component:	mitochondrion [IDA] mitochondrial inner membrane [IDA]
Biological Process:	cellular iron ion homeostasis [IMP]
Molecular Function:	ATPase activity, coupled to transmembrane movement of substances [IMP][ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLLLPRCPVI GRIVRSKFRS GLIRNHSPVI FTVSKLSTQR PLLFNSAVNL WNQAQKDITH  60
   61 KKSVEQFSSA PKVKTQVKKT SKAPTLSELK ILKDLFRYIW PKGNNKVRIR VLIALGLLIS 120
  121 AKILNVQVPF FFKQTIDSMN IAWDDPTVAL PAAIGLTILC YGVARFGSVL FGELRNAVFA 180
  181 KVAQNAIRTV SLQTFQHLMK LDLGWHLSRQ TGGLTRAMDR GTKGISQVLT AMVFHIIPIS 240
  241 FEISVVCGIL TYQFGASFAA ITFSTMLLYS IFTIKTTAWR THFRRDANKA DNKAASVALD 300
  301 SLINFEAVKY FNNEKYLADK YNGSLMNYRD SQIKVSQSLA FLNSGQNLIF TTALTAMMYM 360
  361 GCTGVIGGNL TVGDLVLINQ LVFQLSVPLN FLGSVYRDLK QSLIDMETLF KLRKNEVKIK 420
  421 NAERPLMLPE NVPYDITFEN VTFGYHPDRK ILKNASFTIP AGWKTAIVGS SGSGKSTILK 480
  481 LVFRFYDPES GRILINGRDI KEYDIDALRK VIGVVPQDTP LFNDTIWENV KFGRIDATDE 540
  541 EVITVVEKAQ LAPLIKKLPQ GFDTIVGERG LMISGGEKQR LAIARVLLKN ARIMFFDEAT 600
  601 SALDTHTEQA LLRTIRDNFT SGSRTSVYIA HRLRTIADAD KIIVLDNGRV REEGKHLELL 660
  661 AMPGSLYREL WTIQEDLDHL ENELKDQQEL

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	MLP2	#24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment	Keck JM, et al. (2011)
View Run	MLP2	#29 Asynchronous Prep5-TiO2 Flowthrough	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	UBC7	ATM1	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	ATM1	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..67]	deduced	N/A	Confident ab initio structure predictions are available.
2	View Details	[68..197] [216..414]	PSI-BLAST	745.9897	MsbA
3	View Details	[198..215] [415..690]	PSI-BLAST	745.9897	MsbA

Functions predicted (by domain):

Gene Ontology predictions

No functions predicted.

Term	Confidence	Notes
lipid transporter activity	7.47642599298853	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	5.57844095962502	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	5.57813579764186	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	5.57813579764186	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	5.5689620139321	bayes_pls_golite062009
primary active transmembrane transporter activity	5.55992639965745	bayes_pls_golite062009
active transmembrane transporter activity	5.50005167063544	bayes_pls_golite062009
ATPase activity, coupled	4.98276715440477	bayes_pls_golite062009
heme transporter activity	4.82479229680991	bayes_pls_golite062009
peptide transporter activity	4.7442815698413	bayes_pls_golite062009
anion transmembrane-transporting ATPase activity	4.71935767060308	bayes_pls_golite062009
ATPase activity	4.69795387297193	bayes_pls_golite062009
peptide-transporting ATPase activity	4.63590351019108	bayes_pls_golite062009
nucleoside-triphosphatase activity	4.45923622153365	bayes_pls_golite062009
pyrophosphatase activity	4.39781350157199	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	4.38133275795019	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4.38085303582726	bayes_pls_golite062009
cofactor transporter activity	4.34709589308604	bayes_pls_golite062009
oligopeptide-transporting ATPase activity	4.09365342567844	bayes_pls_golite062009
transporter activity	3.71239480053329	bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism	3.57926427233638	bayes_pls_golite062009
ion transmembrane transporter activity	3.35436118751376	bayes_pls_golite062009
phosphate transmembrane-transporting ATPase activity	3.20894563245332	bayes_pls_golite062009
inorganic anion transmembrane transporter activity	3.16975154423199	bayes_pls_golite062009
hydrolase activity	3.14498892233323	bayes_pls_golite062009
transmembrane transporter activity	3.13960906549884	bayes_pls_golite062009
anion transmembrane transporter activity	3.13913638619234	bayes_pls_golite062009
substrate-specific transporter activity	3.1318898376276	bayes_pls_golite062009
cation transmembrane transporter activity	3.08390071341252	bayes_pls_golite062009
iron ion transmembrane transporter activity	3.05511942104215	bayes_pls_golite062009
ATP binding	3.01346604299372	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	3.00745742755195	bayes_pls_golite062009
drug transmembrane transporter activity	2.97119034312001	bayes_pls_golite062009
adenyl ribonucleotide binding	2.96271391116269	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	2.9271291809464	bayes_pls_golite062009
adenyl nucleotide binding	2.91131545957759	bayes_pls_golite062009
branched-chain aliphatic amino acid transmembrane transporter activity	2.88795687640992	bayes_pls_golite062009
metal ion transmembrane transporter activity	2.88476360771975	bayes_pls_golite062009
purine ribonucleotide binding	2.70262534541085	bayes_pls_golite062009
ribonucleotide binding	2.70178191749524	bayes_pls_golite062009
amine-transporting ATPase activity	2.69529191205818	bayes_pls_golite062009
organic acid transmembrane transporter activity	2.67957846350199	bayes_pls_golite062009
carboxylic acid transmembrane transporter activity	2.67815672695824	bayes_pls_golite062009
purine nucleotide binding	2.6583477492092	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	2.63419811368692	bayes_pls_golite062009
nucleotide binding	2.62374702628143	bayes_pls_golite062009
sterol transporter activity	2.48473697371886	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	2.40292717311506	bayes_pls_golite062009
amine transmembrane transporter activity	2.29486577878686	bayes_pls_golite062009
	2.20174656498665	bayes_pls_golite062009
vitamin transporter activity	2.1653565229854	bayes_pls_golite062009
phosphate transmembrane transporter activity	2.15147988861177	bayes_pls_golite062009
oligopeptide transporter activity	2.05580564974083	bayes_pls_golite062009
transition metal ion transmembrane transporter activity	1.82177108193332	bayes_pls_golite062009
protein transporter activity	1.71214667007262	bayes_pls_golite062009
binding	1.64266915208623	bayes_pls_golite062009
amino acid transmembrane transporter activity	1.59627719545436	bayes_pls_golite062009
cation channel activity	1.33585529285301	bayes_pls_golite062009
molybdate ion transmembrane transporter activity	1.28313088935613	bayes_pls_golite062009
molybdate transmembrane-transporting ATPase activity	1.28313088935613	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions	1.23799860254751	bayes_pls_golite062009
potassium channel activity	1.20877745413881	bayes_pls_golite062009
sulfate transmembrane-transporting ATPase activity	1.1220946941463	bayes_pls_golite062009
dipeptide transporter activity	1.01130176523309	bayes_pls_golite062009
voltage-gated cation channel activity	1.00384984515681	bayes_pls_golite062009
signal transducer activity	0.952448314982579	bayes_pls_golite062009
molecular transducer activity	0.952448314982579	bayes_pls_golite062009
RNA helicase activity	0.94708387424268	bayes_pls_golite062009
thiamin transmembrane transporter activity	0.933872128802939	bayes_pls_golite062009
ATP-dependent RNA helicase activity	0.93133090558732	bayes_pls_golite062009
RNA-dependent ATPase activity	0.91827876091109	bayes_pls_golite062009
voltage-gated ion channel activity	0.889208591820696	bayes_pls_golite062009
motor activity	0.87979065815418	bayes_pls_golite062009
voltage-gated channel activity	0.871525745291603	bayes_pls_golite062009
ion channel activity	0.848261056209476	bayes_pls_golite062009
GTPase activity	0.83849854735032	bayes_pls_golite062009
channel activity	0.806331380134838	bayes_pls_golite062009
passive transmembrane transporter activity	0.806331380134838	bayes_pls_golite062009
substrate-specific channel activity	0.799997700906738	bayes_pls_golite062009
copper ion transmembrane transporter activity	0.798934081014025	bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity	0.767424210804186	bayes_pls_golite062009
helicase activity	0.73689027003638	bayes_pls_golite062009
ATP-dependent helicase activity	0.72833102894594	bayes_pls_golite062009
purine NTP-dependent helicase activity	0.72833102894594	bayes_pls_golite062009
gated channel activity	0.650050847753837	bayes_pls_golite062009
cholesterol transporter activity	0.644421039250979	bayes_pls_golite062009
DNA-dependent ATPase activity	0.62832939629645	bayes_pls_golite062009
protein transmembrane transporter activity	0.46552249844591	bayes_pls_golite062009
catalytic activity	0.368034275052766	bayes_pls_golite062009
receptor activity	0.277332279568238	bayes_pls_golite062009
transmembrane receptor activity	0.243026482777117	bayes_pls_golite062009
neutral amino acid transmembrane transporter activity	0.227570438294493	bayes_pls_golite062009
proton-transporting ATPase activity, rotational mechanism	0.219473333671469	bayes_pls_golite062009
signal recognition particle binding	0.20866768220789	bayes_pls_golite062009
amino acid-transporting ATPase activity	0.147644650870465	bayes_pls_golite062009
nucleic acid binding	0.144904409289829	bayes_pls_golite062009
sulfate transmembrane transporter activity	0.104477131120205	bayes_pls_golite062009
protein binding	0.071010918255742	bayes_pls_golite062009
cation-transporting ATPase activity	0.0536898657672154	bayes_pls_golite062009
structure-specific DNA binding	0.050232896280066	bayes_pls_golite062009
P-P-bond-hydrolysis-driven protein transmembrane transporter activity	0.00571427458217011	bayes_pls_golite062009
macromolecule transmembrane transporter activity	0.00571427458217011	bayes_pls_golite062009

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2