Protein Overview: FET3

General Information:
Name(s) found:	FET3 / YMR058W [SGD]
Description(s) found: Found 23 descriptions. SHOW ALL	Ferro-O2-oxidoreductase required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases [SGD]
Organism:	Saccharomyces cerevisiae
Length:	636 amino acids
Gene Ontology:
Cellular Component:	plasma membrane [IDA ]
Biological Process:	high-affinity iron ion transport [IDA][IMP ] response to copper ion [IGI][IMP]
Molecular Function:	iron ion transmembrane transporter activity [IDA] ferroxidase activity [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTNALLSIAV LLFSMLSLAQ AETHTFNWTT GWDYRNVDGL KSRPVITCNG QFPWPDITVN  60
   61 KGDRVQIYLT NGMNNTNTSM HFHGLFQNGT ASMDGVPFLT QCPIAPGSTM LYNFTVDYNV 120
  121 GTYWYHSHTD GQYEDGMKGL FIIKDDSFPY DYDEELSLSL SEWYHDLVTD LTKSFMSVYN 180
  181 PTGAEPIPQN LIVNNTMNLT WEVQPDTTYL LRIVNVGGFV SQYFWIEDHE MTVVEIDGIT 240
  241 TEKNVTDMLY ITVAQRYTVL VHTKNDTDKN FAIMQKFDDT MLDVIPSDLQ LNATSYMVYN 300
  301 KTAALPTQNY VDSIDNFLDD FYLQPYEKEA IYGEPDHVIT VDVVMDNLKN GVNYAFFNNI 360
  361 TYTAPKVPTL MTVLSSGDQA NNSEIYGSNT HTFILEKDEI VEIVLNNQDT GTHPFHLHGH 420
  421 AFQTIQRDRT YDDALGEVPH SFDPDNHPAF PEYPMRRDTL YVRPQSNFVI RFKADNPGVW 480
  481 FFHCHIEWHL LQGLGLVLVE DPFGIQDAHS QQLSENHLEV CQSCSVATEG NAAANTLDLT 540
  541 DLTGENVQHA FIPTGFTKKG IIAMTFSCFA GILGIITIAI YGMMDMEDAT EKVIRDLHVD 600
  601 PEVLLNEVDE NEERQVNEDR HSTEKHQFLT KAKRFF

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Ho Y, et al. (2002)		AHA1 ARC15 ARC18 ARC19 ARC35 ARC40 ARP2 ARP3 ATG12 ATG5 ATP3 CLU1 CRM1 CYS3 ERG20 FAA4 FET3 GCD1 GCD11 GCD2 GCD6 GCD7 GCN3 GFA1 HYM1 IDH1 KAP122 KGD1 LOS1 MET10 MET18 NMD5 NTG1 PEX19 PFK1 PRB1 PRO3 PST2 PUF3 RFC2 RPC40 RPN1 RPN8 RVB1 SCW4 SUI3 TIF34 UFD4 VAC8 VMA8
View Details	Qiu et al. (2008)		ARN2 ENB1 FET3 FET4 FRE1 FRE2 FRE3 FRE4 FTH1 FTR1 ZRT1

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	MLP2	#24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	SPT21	FET3	1	Unpublished Fields Lab Data
View Screen	PTC4	FET3	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	FET3	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..320] [514..545]	PSI-BLAST	627.228787	Laccase
2	View Details	[321..513]	PSI-BLAST	627.228787	Laccase
3	View Details	[546..636]	deduced	N/A	No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2