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Protein Overview: RSC9

General Information:
Name(s) found: RSC9 / YML127W [SGD]
Description(s) found:
Found 25 descriptions.
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  • Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 581 amino acids

    Gene Ontology:
    Cellular Component: RSC complex [IDALink to PubMed articleLink to PubMed articleLink to PubMed article]
    Biological Process: chromatin remodeling [IPILink to PubMed article]
    ATP-dependent chromatin remodeling [IDALink to PubMed article]
    rRNA transcription [IMPLink to PubMed article]
    regulation of transcription from RNA polymerase II promoter [IMPLink to PubMed article]
    Molecular Function: DNA-dependent ATPase activity [IDALink to PubMed article]
    chromatin binding [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNSLASNTPL NGTPVSEAPA TSSEPVNMFE TMVANPIKVS RLQSNGVLTG PAANTKSIHY  60
   61 SLANFNVFQS LPKETARGVD DLTRMEMALL SGIPEEIKWS LKKYLTYSNK APYMISLRTL 120
  121 PDLLPLFKTF ILPLERIVEG LNKSSICDSK AMDSLQMGLN ALLILRNLAQ DTDSVQILVK 180
  181 DREIKSFILF ILKKFQCVAT GDNKWQLYEG NATFFNELTH YTLDLMEAIS SYIAPAMKDD 240
  241 HYFQTLVSIL NYTKDRYMVI SILRSLSRLL VRSKANEESA ADNLDHKTLS LIVSFLLLEC 300
  301 DSELIIASLD FLYQYILPGS QRITELFKSK ECSLILEATL PNLLSYNIAT PDYHLLQKHK 360
  361 IRLIKRLKPP APKEPPNLSE DLFQQLFKLN EPLRSTAWLR CCFEPVQEAE FTQISLWRSY 420
  421 ESKFGQPVRE SGRKLLPAVE FIKNVSNAFN NAAAIVITDP VTGKKRFVIK GIQPRFKALG 480
  481 IADGERESQV PISALKSKFL NDSKEITPAR QNSIPEVKFP QELSDVSKVA CTFLCLLSND 540
  541 TDDGAGSAFC QRIRPLVLHK LADIPPLTLA LSEYMENTSG L

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ARP7 ARP9 HTL1 NFI1 NPL6 RSC1 RSC2 RSC3 RSC30 RSC4 RSC58 RSC6 RSC8 RSC9 RTT102 SFH1 STH1
    View Details Krogan NJ, et al. (2006) ARP7 ARP9 ATG16 CSH1 GRS2 HTL1 MGR1 NFI1 NPL6 PCL9 RIM15 RSC1 RSC2 RSC3 RSC4 RSC58 RSC6 RSC8 RSC9 RTT102 SFH1 STH1 URC2 YIL177C
    View Details Gavin AC, et al. (2006) ARP7 NPL6 RSC1 RSC2 RSC3 RSC4 RSC58 RSC6 RSC8 RSC9 SFH1 STH1
    View Details Qiu et al. (2008) HTL1 RSC4 RSC58 RSC9

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run KIP3 No Comments Cheeseman IM, et al. (2002)
    View Run MIH1 control 1 McCusker D, et al (2007)
    View Run MIH1 control 2 McCusker D, et al (2007)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run MLP2 #31 Asynchronous Prep (Protease cleavage) Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data RSC9 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..54] deduced N/A Confident ab initio structure predictions are available.
    2 View Details [55..500] MSA 1.002847 View MSA. No confident structure predictions are available.
    3 View Details [501..581] deduced N/A No confident structure predictions are available.
    4 View Details [482..581] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • transcription regulator activity
    		•  5.23858959608048 bayes_pls_golite062009
  • DNA binding
    		•  4.78517210147551 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.72059012764202 bayes_pls_golite062009
  • transcription factor activity
    		•  4.02736190679869 bayes_pls_golite062009
  • binding
    		•  3.37660003833383 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.41045867230388 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.21432668306508 bayes_pls_golite062009
  • transcription activator activity
    		•  2.13702350917359 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.9708626903609 bayes_pls_golite062009
  • transcription elongation regulator activity
    		•  1.75305601393584 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.26260991083343 bayes_pls_golite062009
  • transcription factor binding
    		•  0.752335897765285 bayes_pls_golite062009
  • protein binding
    		•  0.726445167461826 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.490809930581315 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity, enhancer binding
    		•  0.0406721670764369 bayes_pls_golite062009
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle