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Protein Overview: CMP2

General Information:
Name(s) found: CMP2 / YML057W [SGD]
Description(s) found:
Found 24 descriptions.
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  • Calcineurin A; one isoform (the other is CNA1) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1 [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 604 amino acids

    Gene Ontology:
    Cellular Component: calcineurin complex [IPILink to PubMed articleLink to PubMed article][ISSLink to PubMed article]
    cytoplasm [TASLink to PubMed article]
    Biological Process: adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion [IMPLink to PubMed article]
    cellular ion homeostasis [IMPLink to PubMed article]
    Molecular Function: calcium-dependent protein serine/threonine phosphatase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSDAIRNTE QINAAIKIIE NKTERPQSST TPIDSKASTV AAANSTATET SRDLTQYTLD  60
   61 DGRVVSTNRR IMNKVPAITS HVPTDEELFQ PNGIPRHEFL RDHFKREGKL SAAQAARIVT 120
  121 LATELFSKEP NLISVPAPIT VCGDIHGQYF DLLKLFEVGG DPATTSYLFL GDYVDRGSFS 180
  181 FECLIYLYSL KLNFNDHFWL LRGNHECKHL TSYFTFKNEM LHKYNLDIYE KCCESFNNLP 240
  241 LAALMNGQYL CVHGGISPEL NSLQDINNLN RFREIPSHGL MCDLLWADPI EEYDEVLDKD 300
  301 LTEEDIVNSK TMVPHHGKMA PSRDMFVPNS VRGCSYAFTY RAACHFLQET GLLSIIRAHE 360
  361 AQDAGYRMYK NTKTLGFPSL LTLFSAPNYL DTYNNKAAIL KYENNVMNIR QFNMTPHPYW 420
  421 LPDFMDVFTW SLPFVGEKVT EMLVAILNIC TEDELENDTP VIEELVGTDK KLPQAGKSEA 480
  481 TPQPATSASP KHASILDDEH RRKALRNKIL AVAKVSRMYS VLREETNKVQ FLKDHNSGVL 540
  541 PRGALSNGVK GLDEALSTFE RARKHDLINE KLPPSLDELK NENKKYYEKV WQKVHEHDAK 600
  601 NDSK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CMD1 CMP2 CNB1
    View Details (MIPS) Mewes HW, et al. (2004) CMP2 CNA1 CNB1
    View Details Krogan NJ, et al. (2006) CMD1 CMK1 CMK2 CMP2 CNA1 CNB1 MYO3 MYO5 YGL242C
    View Details Ho Y, et al. (2002) ARO1 BCK1 BUD14 CHS1 CMD1 CMK2 CMP2 CNA1 CNB1 COF1 CPR1 DBP7 DOG1 EDE1 GIS4 HCH1 HSP104 HUL5 HYP2 IDH1 ILS1 IPP1 KEL1 KEL2 KIN2 KOG1 KRE6 KSP1 MLC1 MYO2 MYO3 MYO4 MYO5 PGM2 POP2 PRI2 PST2 PSY2 RFC3 RPN7 SHE3 SHE4 SOD1 SPC110 TEF4 TFC4 TPD3 UBA1 VAS1 VPS13 YNK1
    View Details Qiu et al. (2008) CMP2 CNA1 CNB1 PPH22

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2 Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data CMP2 Huh WK, et al. (2003)

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..604] PSI-BLAST 1724.0 Protein phosphatase-2B (PP-2B, calcineurin A subunit)


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle