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Protein Overview: TSA1

General Information:
Name(s) found: TSA1 / YML028W [SGD]
Description(s) found:
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  • gi|6323613|ref|NP_013684.1| Ubiquitous housekeeping thioredoxin peroxidase, reduces reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; mediates redox regulation of the nuclear localization of Yap1p; deletion results in mutat [NCBI NR]
  • gi|575691|emb|CAA86627.1| TSA [Saccharomyces cerevisiae] [NCBI NR]
  • pir||A47362 thiol-specific antioxidant - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|464970|sp|P34760.3|TSA1_YEAST RecName: Full=Peroxiredoxin TSA1; AltName: Full=Thioredoxin peroxidase; AltName: Full=Cytoplasmic thiol peroxidase 1; Short=cTPx 1; AltName: Full=Thiol-specific antioxidant protein 1; AltName: Full=PRP [NCBI NR]
  • gi|349196|gb|AAA16374.1| thiol-specific antioxidant protein [Saccharomyces cerevisiae] [NCBI NR]
  • Peroxiredoxin TSA1 OS=Saccharomyces cerevisiae GN=TSA1 PE=1 SV=3 [Swiss-Prot]
  • TSA1 Thiol-specific antioxidant [mips]
  • Thioredoxin peroxidase, acts as both a ribosome-associated and free cytoplasmic antioxidant; self-associates to form a high-molecular weight chaperone complex under oxidative stress; deletion results in mutator phenotype [SGD]
  • TSA1, Chr XIII from 220138-220728 [yeast_orfs2]
  • Chr XIII from 220138-220728 [yeastorf3.fasta]
  • TSA1 SGDID:S0004490, Chr XIII from 220138-220728, Verified ORF [yeastflysequest.fasta]
  • Thioredoxin-peroxidase (TPx), reduces H2O2 and alkyl hydroperoxides with the use of hydrogens provided by thioredoxin, thioredoxin reductase, and NADPH; provides protection against oxidation systems that generate reactive oxygen and sulfur species [Saccha [nrdb_11152004_Chlamydomonas]
  • TSA1 SGDID:S000004490, Chr XIII from 220138-220728, Verified ORF, "Ubiquitous housekeeping thioredoxin peroxidase, reduces reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; mediates redox regulation of the nuclear localizat [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • TSA1 SGDID:S000004490, Chr XIII from 220138-220728, Verified ORF, "Thioredoxin peroxidase, acts as both a ribosome-associated and free cytoplasmic antioxidant; self-associates to form a high-molecular weight chaperone complex under oxidative stress; delet [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta]
  • thiol-specific antioxidant protein [nr-271106-contam.fasta]
  • TSA [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Peroxiredoxin TSA1 (Thioredoxin peroxidase) (Cytoplasmic thiol peroxidase 1) (cTPx 1) (Thiol-specific antioxidant protein 1) (PRP) [nr-271106-contam.fasta]
  • Ubiquitous housekeeping thioredoxin peroxidase, reduces reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; mediates redox regulation of the nuclear localization of Yap1p; deletion results in mutator phenotype; Tsa1p [Sacchar [nr-271106-contam.fasta]
  • TSA1 SGDID:S000004490, Chr XIII from 220138-220728, Verified ORF, "Thioredoxin peroxidase, acts as both a ribosome-associated and free cytoplasmic antioxidant; self-associates to form a high-molecular weight chaperone complex under oxidative stress; deletion results in mutator phenotype" [yeast-bovrabprots.fasta]
  • TSA1 SGDID:S000004490, Chr XIII from 220138-220728, Verified ORF, "Ubiquitous housekeeping thioredoxin peroxidase, reduces reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; mediates redox regulation of the nuclear localization of Yap1p; deletion results in mutator phenotype" [yeast-contam_custom.fasta]
  • [chemostatdb.fasta]
  • Peroxiredoxin TSA1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TSA1 PE=1 SV=3 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • TSA1 SGDID:S000004490, Chr XIII from 220138-220728, Genome Release 64-1-1, Verified ORF, "Thioredoxin peroxidase, acts as both a ribosome-associated and free cytoplasmic antioxidant; self-associates to form a high-molecular weight chaperone complex under oxidative stress; deletion results in mutator phenotype" [yeast-030211-contam.fasta]
  • TSA1 SGDID:S000004490, Chr XIII from 220138-220728, Genome Release 64-2-1, Verified ORF, "Thioredoxin peroxidase; acts as both ribosome-associated and free cytoplasmic antioxidant; self-associates to form high-molecular weight chaperone complex under oxidative stress; chaperone activity essential for growth in zinc deficiency; required for telomere length maintenance; protein abundance increases, forms cytoplasmic foci during DNA replication stress; TSA1 has a paralog, TSA2, that arose from the whole genome duplication" [20141208_orf_trans.fasta]
  • TR1303|c0_g1_i1|g.981 ORF TR1303|c0_g1_i1|g.981 TR1303|c0_g1_i1|m.981 type:complete len:197 (+) TR1303|c0_g1_i1:2862-3452(+) [Y12_S_cerevisiae-Sep2015-contam.fasta]
  • TR1152|c0_g1_i1|g.789 ORF TR1152|c0_g1_i1|g.789 TR1152|c0_g1_i1|m.789 type:complete len:197 (+) TR1152|c0_g1_i1:2858-3448(+) [DBVPG6044_S_cerevisiae-Sep2015-contam.fasta]
  • YML028W SGDID:S000004490, Chr XIII from 220138-220728, Genome Release 64-1-1, Verified ORF, "Thioredoxin peroxidase, acts as both a ribosome-associated and free cytoplasmic antioxidant; self-associates to form a high-molecular weight chaperone complex under oxidative stress; deletion results in mutator phenotype" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
  • asmbl_4456|g.3257 ORF asmbl_4456|g.3257 asmbl_4456|m.3257 type:complete len:197 (+) asmbl_4456:2858-3448(+) [DBVPG6044_Trinity_v2_2_0_PASA_6May2016-contam.fasta]
  • ID=asmbl_4456|g.2705 ORF ID=asmbl_4456|g.2705 ID=asmbl_4456|m.2705 type:complete len:197 (+) ID=asmbl_4456:2860-3450(+) [DBVPG6044_quiverGenomes_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
  • ID=asmbl_4449|g.2646 ORF ID=asmbl_4449|g.2646 ID=asmbl_4449|m.2646 type:complete len:197 (+) ID=asmbl_4449:2857-3447(+) [Y12_quiver_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 196 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed articleLink to PubMed article]
    Biological Process: response to oxidative stress [IDALink to PubMed article][IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: thioredoxin peroxidase activity [IDALink to PubMed articleLink to PubMed article][IMPLink to PubMed articleLink to PubMed article]
    unfolded protein binding [IMPLink to PubMed article]
    peroxiredoxin activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVAQVQKQAP TFKKTAVVDG VFDEVSLDKY KGKYVVLAFI PLAFTFVCPT EIIAFSEAAK  60
   61 KFEEQGAQVL FASTDSEYSL LAWTNIPRKE GGLGPINIPL LADTNHSLSR DYGVLIEEEG 120
  121 VALRGLFIID PKGVIRHITI NDLPVGRNVD EALRLVEAFQ WTDKNGTVLP CNWTPGAATI 180
  181 KPTVEDSKEY FEAANK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) TRX1 TSA1
    View Details Krogan NJ, et al. (2006) TSA1 TSA2
    View Details Gavin AC, et al. (2006) ABZ1 MPA43 TKL1 TSA1
    View Details Gavin AC, et al. (2002) ACC1 ASC1 CCT8 CHC1 CLC1 CLU1 CPA2 FDH1 GCN20 GFA1 GUS1 ILV1 KAP123 LYS12 MRPL3 PSA1 RPA135 RPB2 RPN10 RPN11 RPN12 RPN8 RPT3 RPT5 RPT6 SAM1 SEC27 SMC3 TCB1 TIF1, TIF2 TSA1 TUB3 URA7 VAS1 YHB1 YOL098C

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run SDO1 No Comments Hazbun TR, et al. (2003)
    View Run DSN1 No Comments Hazbun TR, et al. (2003)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run VAM3 sample: hx4 Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX11 - both fusion and trans-SNARE complex formation take place. Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX12 - trans-SNARE complex formation and fusion are inhibited (control). Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX14 - mixture in detergent (control). Hao Xu, et al. (2010)
    View Run VAM3 hx23: mixture in detergent (control) Investigating Vam3p, Nyv1p and their partners in trans-SNARE complex Hao Xu, et al. (2010)
    View Run MLP2 #19 Asynchronous Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #10 Mitotic Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #19b Asynchronous Prep1-new search criteria Keck JM, et al. (2011)
    View Run MLP2 #19a Asynchronous Prep1-new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data TSA1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..196] PSI-BLAST 785.211549 Thioredoxin peroxidase 2 (thioredoxin peroxidase B, 2-cys peroxiredoxin)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • alkyl hydroperoxide reductase activity
    		•  4.29610283853788 bayes_pls_golite062009
  • antioxidant activity
    		•  3.8464796631544 bayes_pls_golite062009
  • peroxidase activity
    		•  3.43831566988273 bayes_pls_golite062009
  • oxidoreductase activity, acting on peroxide as acceptor
    		•  3.43831566988273 bayes_pls_golite062009
  • selenium binding
    		•  2.92496040718744 bayes_pls_golite062009
  • glutathione peroxidase activity
    		•  2.56524997297011 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.30799114442278 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors
    		•  2.23310780102446 bayes_pls_golite062009
  • peroxiredoxin activity
    		•  2.12777217096121 bayes_pls_golite062009
  • thioredoxin peroxidase activity
    		•  1.96134566495756 bayes_pls_golite062009
  • protein disulfide oxidoreductase activity
    		•  1.47769936616412 bayes_pls_golite062009
  • disulfide oxidoreductase activity
    		•  1.32811008894503 bayes_pls_golite062009
  • transferase activity
    		•  1.26687471229876 bayes_pls_golite062009
  • binding
    		•  1.25802922431343 bayes_pls_golite062009
  • protein binding
    		•  1.18479617596618 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.11518182894524 bayes_pls_golite062009
  • signal transducer activity
    		•  1.11518182894524 bayes_pls_golite062009
  • catalytic activity
    		•  0.672192331361968 bayes_pls_golite062009
  • peptide binding
    		•  0.374493676068876 bayes_pls_golite062009
    		• 0.359224524631956 bayes_pls_golite062009
  • NADH dehydrogenase activity
    		•  0.23291471505999 bayes_pls_golite062009
  • copper ion binding
    		•  0.178842772364502 bayes_pls_golite062009
  • NADH dehydrogenase (ubiquinone) activity
    		•  0.16328723676608 bayes_pls_golite062009
  • NADH dehydrogenase (quinone) activity
    		•  0.0434052164026002 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.65

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle