Protein Overview: LSM1

General Information:
Name(s) found:	LSM1 / YJL124C [SGD]
Description(s) found: Found 32 descriptions. SHOW ALL	Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs [SGD]
Organism:	Saccharomyces cerevisiae
Length:	172 amino acids
Gene Ontology:
Cellular Component:	mRNA cap binding complex [IPI][TAS] cytoplasmic mRNA processing body [IDA][IMP]
Biological Process:	deadenylation-dependent decapping of nuclear-transcribed mRNA [IGI][IMP][IPI] mRNA catabolic process [TAS] nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [IGI][IMP]
Molecular Function:	RNA binding [TAS] RNA cap binding [IGI][IMP][IPI][TAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSANSKDRNQ SNQDAKRQQQ NFPKKISEGE ADLYLDQYNF TTTAAIVSSV DRKIFVLLRD  60
   61 GRMLFGVLRT FDQYANLILQ DCVERIYFSE ENKYAEEDRG IFMIRGENVV MLGEVDIDKE 120
  121 DQPLEAMERI PFKEAWLTKQ KNDEKRFKEE THKGKKMARH GIVYDFHKSD MY

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		BRR2 DHH1 DIB1 KEM1 LSM1 LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 PAT1 PRP24 PRP3 PRP31 PRP4 PRP6 PRP8 SMD2 SNU114 SNU66
View Details	Krogan NJ, et al. (2006)		KEM1 LSM1 LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 LSM8 PAT1 PRP24 YGR054W
View Details	Gavin AC, et al. (2006)		KRS1 LSM1 LSM5 PAT1
View Details	Gavin AC, et al. (2002)		AAR2 ASC1 BRR1 BUD31 CDC33 CEF1 CLF1 CSN12 CUS1 CWC2 CWC22 CWC23 DCP2 DHH1 DIB1 ECM2 ERB1 GCN2 HSH155 HTA1 IMG1 KRS1 LEA1 LIN1 LSM1 LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 LUC7 MRP7 MRPL28 MRPL3 MRPL35 MRPL38 MRPL4 MRPL8 MRPS5 MSL1 MUD1 NAM7 NOG2 NOP1 NUG1 PAT1 PRP11 PRP18 PRP19 PRP21 PRP24 PRP28 PRP3 PRP31 PRP38 PRP39 PRP4 PRP40 PRP42 PRP43 PRP46 PRP6 PRP8 PRP9 RSE1 RVB2 SLU7 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNP1 SNT309 SNU114 SNU23 SNU56 SNU66 SNU71 SPP381 SPP382 SQS1 SRB2 SRO9 STO1 SYF1 TOS4 UTP21 YML6
View Details	Ho Y, et al. (2002)		DCP2 DHH1 GPG1 LSM1 LSM2 LSM4 LSM7 PAT1 PEX19
View Details	Qiu et al. (2008)		CBC2 DCP1 DCP2 DCS2 DHH1 EDC3 KEM1 LSM1 PAT1

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	LSM2	LSM1	2	Uetz P, et al. (2000)
View Screen	LSM4	LSM1	2	Uetz P, et al. (2000)

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	LSM1	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..172]	PSI-BLAST	85.616428	Archaeal homoheptameric Sm protein

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
	9.36615441177233	bayes_pls_golite062009
RNA binding	5.81718051012035	bayes_pls_golite062009
nucleic acid binding	2.69031444148163	bayes_pls_golite062009
mRNA binding	2.57166143288861	bayes_pls_golite062009
binding	2.04681172391952	bayes_pls_golite062009
protein binding	0.187097443004706	bayes_pls_golite062009

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2