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Protein Overview: VPS53

General Information:
Name(s) found: VPS53 / YJL029C [SGD]
Description(s) found:
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  • gi|6322431|ref|NP_012505.1| Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; required for vacuolar protein sorting; Vps53p [ [NCBI NR]
  • gi|1352968|sp|P47061.1|VPS53_YEAST RecName: Full=Vacuolar protein sorting-associated protein 53 [NCBI NR]
  • pir||S56801 hypothetical protein YJL029c - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1008148|emb|CAA89320.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • (P47061) Hypothetical 95.4 kDa protein in MAD2-RNR2 intergenic region [Swiss-Prot]
  • Vacuolar protein sorting-associated protein 53 OS=Saccharomyces cerevisiae GN=VPS53 PE=1 SV=1 [Swiss-Prot]
  • VPS53 Subunit of VP51-54 complex, required for protein sorting at the yeast late Golgi [mips]
  • Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; required for vacuolar protein sorting [SGD]
  • VPS53, Chr X from 388081-390549, reverse complement [yeast_orfs2]
  • Chr X from 388081-390549, reverse complement [yeastorf3.fasta]
  • Chr X from 390549-388081, reverse complement [yeastorf5.fasta]
  • VPS53 SGDID:S0003566, Chr X from 390769-388301, reverse complement, Verified ORF [yeastflysequest.fasta]
  • Required for Vacuolar Protein Sorting; Vps53p is a hydrophilic protein that is peripherally associated with the late Golgi and forms a stable complex with Vps52p and Vps54p. [Saccharomyces cerevisiae]gi|1008148|emb|CAA89320.1| unnamed protein product [Sa [nrdb_11152004_Chlamydomonas]
  • VPS53 SGDID:S000003566, Chr X from 390769-388301, reverse complement, Verified ORF, "Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the la [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • VPS53 SGDID:S000003566, Chr X from 390848-388380, reverse complement, Verified ORF, "Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the la [yeast-contam.fasta]
  • VPS53 SGDID:S000003566, Chr X from 390847-388379, reverse complement, Verified ORF, "Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the la [yeast-200209-contam.fasta]
  • Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; required for vacuolar protein sorting; Vps53p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Vacuolar protein sorting-associated protein 53 [nr-271106-contam.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • VPS53 SGDID:S000003566, Chr X from 390847-388379, reverse complement, Verified ORF, "Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; required for vacuolar protein sorting" [yeast-bovrabprots.fasta]
  • VPS53 SGDID:S000003566, Chr X from 390848-388380, reverse complement, Verified ORF, "Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; required for vacuolar protein sorting" [yeast-contam_custom.fasta]
  • [chemostatdb.fasta]
  • Vacuolar protein sorting-associated protein 53 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=VPS53 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • VPS53 SGDID:S000003566, Chr X from 390853-388385, Genome Release 64-1-1, reverse complement, Verified ORF, "Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; required for vacuolar protein sorting" [yeast-030211-contam.fasta]
  • VPS53 SGDID:S000003566, Chr X from 390853-388385, Genome Release 64-2-1, reverse complement, Verified ORF, "Component of the GARP (Golgi-associated retrograde protein) complex; GARP is required for the recycling of proteins from endosomes to the late Golgi, and for mitosis after DNA damage induced checkpoint arrest; required for vacuolar protein sorting; members of the GARP complex are Vps51p-Vps52p-Vps53p-Vps54p," [20141208_orf_trans.fasta]
  • YJL029C SGDID:S000003566, Chr X from 390853-388385, Genome Release 64-1-1, reverse complement, Verified ORF, "Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; required for vacuolar protein sorting" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 822 amino acids

    Gene Ontology:
    Cellular Component: GARP complex [IPILink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Golgi apparatus [IDALink to PubMed article][TASLink to PubMed article]
    Biological Process: retrograde transport, endosome to Golgi [IDALink to PubMed article]
    Golgi to vacuole transport [IMPLink to PubMed article]
    Molecular Function: protein binding [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLEGTVDYDP LEDITNILFS KESLNNIDEL ISITRSYKKQ LQEDILKEEN ELKEHPKNSA  60
   61 EIEASLRKVF QDFKETQDVS ASTELTISNL TEGISYLDIA KKNLTHSLTL FQNLKILTDS 120
  121 YIQCNELLSQ GSFKKMVSPY KIMCSLAENT FISYKSLDEI NYLLSSISRL KGDTLSKIKQ 180
  181 NYNALFSGGN ISEHDTALTM ELREGACELL DCDTSTRAQM IDWCLDKLLF EMKEIFRVDD 240
  241 EAGSLENLSR RYIYFKKILN NFNSKFADYF LKDWEMAVRL TTTFYHITHK DLQTLLKREF 300
  301 KDKNPSIDLF MTALQSTLDF EKYIDVRFSK KIKEPKLSSC FEPYLTLWVS HQNQMMEKKF 360
  361 LSYMSEPKYP SNETESLVLP SSADLFRTYR SVLTQTLELI DNNANDSILT SLANFFSRWL 420
  421 QTYSQKILLP LLLPDNIEVQ DKLEAAKYTV LLINTADYCA TTIDQLEDKL SEFSGNREKL 480
  481 ANSFTKTKNI YDDLLAKGTS FLLNRVIPLD LNFVWREFIN NDWSNAAIED YSRYMVTLKS 540
  541 VLKMPALTDA SIKQQQEQPS TLAFILSQFN RDVYKWNFLD KVIDIITTNF VSNTIRLLQP 600
  601 VPPFSLAGSK RKFETRTVVN IGEQLLLDLE LLKEIFHTLP ESVSNDSDLR ENTSYKRVKR 660
  661 HADNNIDQLL KFIKLLMAPL DSADDYYETY SKLTNNNPDS AVWSFVLALK GIPWDLALWK 720
  721 KLWSAYNLET DDTDEGSRPD SNRDLFIFKW DKVLLGQFEN NLARMQDPNW SKFVRQDLKI 780
  781 SPPVMKRIVS TPQIQQQKEE QKKQSLSVKD FVSHSRFFNR GT

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) VPS52 VPS53 VPS54
    View Details Krogan NJ, et al. (2006) TOR1 VPS52 VPS53 VPS54
    View Details Gavin AC, et al. (2006) KAR2 VPS52 VPS53 VPS54
    View Details Gavin AC, et al. (2002) ACT1 AIM31 CFT1 CFT2 CKA1 CLP1 ENO2 FIP1 GLC7 HHF1, HHF2 HTA1 MPE1 PAP1 PCF11 PFK1 PFS2 PTA1 PTI1 REF2 RNA14 RNA15 RSA3 SEC13 SEC31 SSA3 SSU72 SYC1 TAF6 TIF4632 TYE7 VID24 VMR1 VPS51 VPS52 VPS53 VPS54 YCL046W YSH1 YTH1
    View Details Qiu et al. (2008) APL4 VPS51 VPS52 VPS53 VPS54

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data VPS53 and COP1 Huh WK, et al. (2003)
    View Data VPS53 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..30]
    [219..520]    		 ORFEUS 7.96 (+)-bornyl diphosphate synthase
    2 View Details [31..49]
    [67..77]
    [191..218]    		 ORFEUS 7.96 (+)-bornyl diphosphate synthase
    3 View Details [50..66]
    [78..190]    		 ORFEUS 7.96 (+)-bornyl diphosphate synthase
    4 View Details [521..822] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle