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Protein Overview: VPS52

General Information:
Name(s) found: VPS52 / YDR484W [SGD]
Description(s) found:
Found 28 descriptions.
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  • Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; involved in localization of actin and chitin [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 641 amino acids

    Gene Ontology:
    Cellular Component: GARP complex [IPILink to PubMed article]
    Golgi apparatus [IDALink to PubMed article][TASLink to PubMed article]
    Biological Process: actin filament-based process [IGILink to PubMed article]
    retrograde transport, endosome to Golgi [IDALink to PubMed article]
    Golgi to vacuole transport [IMPLink to PubMed article]
    Molecular Function: protein binding [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDVLKEVLSL DQDKFDQLKE TSRDKTNETD DPFENYLKDC KFKAPSNKDQ SPFAKLKSLQ  60
   61 ETHSNNEAAI NIIIPQLIDY LTEFTNRLSN YTQDLDFIKK KSNELQSLLE YNSTKLAHIS 120
  121 PMVNDLMIPP ELIDDIIKGK INESWQDNIT FIADKEEIYN KYRSNNLDQD NKDAENSAML 180
  181 APKDFDKLCQ LLDILKNVIL ERSKRLIISK IKTLRSHNPV PSQRIQNKLL KVQKIFPFIR 240
  241 DNNLSLALEL RQAYCYTMKW YYREYFSRYI RSLTILQFQQ IDSQFALGNG LSTTSVSGFN 300
  301 NSPSLFFSNY LTTSASNAFY NKLPVTDEKI DKYFQIKKRL NILTQEDNTV MVSQIAENNT 360
  361 TKNYIEIGFK NLNLAILDNC TVEYHFLKDF FAMNGDNFEE INGLLEQIFQ PTFDEATTYT 420
  421 QQLIQYNYDI FGVLISIRVA NQLQFESERR GIPSMFDSFL NGQLIQLWPR FQQLVDFQCE 480
  481 SLRKAAITTN VAKYAGNSST SNSSPLTSPH ELTVQFGKFL SSFLTLAITH KQSIDERSEP 540
  541 LYNSIIRLRN DFETVMTKCS KKTKSPERFL ATNYMYLYNN LQQLHLHLNI NDSDAQNYNF 600
  601 DSAENVGTKV ANDDDNDSSV PLIIRETENH FKTLVEAFTR N

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) VPS52 VPS53 VPS54
    View Details Krogan NJ, et al. (2006) TOR1 VPS52 VPS53 VPS54
    View Details Gavin AC, et al. (2006) KAR2 VPS52 VPS53 VPS54
    View Details Gavin AC, et al. (2002) VPS51 VPS52 VPS53 VPS54
    View Details Qiu et al. (2008) GGA1 VPS45 VPS51 VPS52 VPS53 VPS54

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data VPS52 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..122]
    [255..327]    		 ORFEUS 7.21 TRF1
    2 View Details [123..254] ORFEUS 7.21 TRF1
    3 View Details [328..641] MSA 1.011908 View MSA. Confident ab initio structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle