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View Structure Prediction Details

Protein: VPS53
Organism: Saccharomyces cerevisiae
Length: 822 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for VPS53.

Description E-value Query
Range
Subject
Range
gi|151945055 - gi|151945055|gb|EDN63306.1| vacuolar sorting protein [Saccharomyces cerevisiae YJM789]
VPS53 - Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, wh...
VPS53_YEAST - Vacuolar protein sorting-associated protein 53 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S28...
0.0 [1..822] [1..822]
gi|25405376, gi|... - pir||E96541 unknown protein [imported] - Arabidopsis thaliana, gi|12322335|gb|AAG51191.1|AC079279_1...
0.0 [10..737] [6..765]
gi|13491871 - gi|13491871|gb|AAK27973.1|AF246287_1 unknown [Homo sapiens]
0.0 [7..587] [41..672]
gi|16184516 - gi|16184516|gb|AAL13808.1| LD27356p [Drosophila melanogaster]
0.0 [7..601] [44..682]
CE21152 - WBGene00011502 status:Partially_confirmed SW:P34561 protein_id:CAA81595.1
0.0 [11..718] [35..729]
vps53 - GARP complex subunit Vps53
VPS53_SCHPO - Vacuolar protein sorting-associated protein 53 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843...
0.0 [4..737] [15..709]

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Predicted Domain #1
Region A:
Residues: [1-30]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLEGTVDYDP LEDITNILFS KESLNNIDEL 

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [219-520]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QMIDWCLDKL LFEMKEIFRV DDEAGSLENL SRRYIYFKKI LNNFNSKFAD YFLKDWEMAV  60
   61 RLTTTFYHIT HKDLQTLLKR EFKDKNPSID LFMTALQSTL DFEKYIDVRF SKKIKEPKLS 120
  121 SCFEPYLTLW VSHQNQMMEK KFLSYMSEPK YPSNETESLV LPSSADLFRT YRSVLTQTLE 180
  181 LIDNNANDSI LTSLANFFSR WLQTYSQKIL LPLLLPDNIE VQDKLEAAKY TVLLINTADY 240
  241 CATTIDQLED KLSEFSGNRE KLANSFTKTK NIYDDLLAKG TSFLLNRVIP LDLNFVWREF 300
  301 IN

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.96
Match: 1n1bA
Description: (+)-bornyl diphosphate synthase
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [31-49]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ISITRSYKKQ LQEDILKEE

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [67-77]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RKVFQDFKET Q

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [191-218]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ISEHDTALTM ELREGACELL DCDTSTRA

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.96
Match: 1n1bA
Description: (+)-bornyl diphosphate synthase
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [50-66]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NELKEHPKNS AEIEASL

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [78-190]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DVSASTELTI SNLTEGISYL DIAKKNLTHS LTLFQNLKIL TDSYIQCNEL LSQGSFKKMV  60
   61 SPYKIMCSLA ENTFISYKSL DEINYLLSSI SRLKGDTLSK IKQNYNALFS GGN

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.96
Match: 1n1bA
Description: (+)-bornyl diphosphate synthase
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [521-822]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NDWSNAAIED YSRYMVTLKS VLKMPALTDA SIKQQQEQPS TLAFILSQFN RDVYKWNFLD  60
   61 KVIDIITTNF VSNTIRLLQP VPPFSLAGSK RKFETRTVVN IGEQLLLDLE LLKEIFHTLP 120
  121 ESVSNDSDLR ENTSYKRVKR HADNNIDQLL KFIKLLMAPL DSADDYYETY SKLTNNNPDS 180
  181 AVWSFVLALK GIPWDLALWK KLWSAYNLET DDTDEGSRPD SNRDLFIFKW DKVLLGQFEN 240
  241 NLARMQDPNW SKFVRQDLKI SPPVMKRIVS TPQIQQQKEE QKKQSLSVKD FVSHSRFFNR 300
  301 GT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle