Protein Overview: YCK1

General Information:
Name(s) found:	YCK1 / YHR135C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6321927\|ref\|NP_012003.1\| Palmitoylated, plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking; provides an essential function overlapping with that of Yck2p; [NCBI NR] gi\|500684\|gb\|AAB68417.1\| Yck1p: membrane-bound casein kinase I homolog [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S29521 casein kinase I homolog YCK1 - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|173208\|gb\|AAA35229.1\| casein kinase I [Saccharomyces cerevisiae] [NCBI NR] gi\|140436\|sp\|P23291.1\|KC11_YEAST RecName: Full=Casein kinase I homolog 1 [NCBI NR] Casein kinase I homolog 1 OS=Saccharomyces cerevisiae GN=YCK1 PE=1 SV=1 [Swiss-Prot] (P23291) Casein kinase I homolog 1 (EC 2.7.1.-) [Swiss-Prot] YCK1 Casein kinase I isoform [mips] Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking; provides an essential function overlapping with that of Yck2p [SGD] YCK1, Chr VIII from 372695-374311, reverse complement [yeast_orfs2] Chr VIII from 372695-374311, reverse complement [yeastorf3.fasta] Chr VIII from 374311-372695, reverse complement [yeastorf5.fasta] YCK1 SGDID:S0001177, Chr VIII from 374311-372695, reverse complement, Verified ORF [yeastflysequest.fasta] YCK1 SGDID:S0001177, Chr VIII from 374312-372696, reverse complement, Verified ORF [10112005cervSGD.fasta] Yck1p [Saccharomyces cerevisiae]gi\|500684\|gb\|AAB68417.1\| Yck1p: membrane-bound casein kinase I homolog [Saccharomyces cerevisiae]gi\|140436\|sp\|P23291\|CK11_YEAST Casein kinase I homolog 1gi\|320647\|pir\|\|S29521 casein kinase I homolog YCK1 - yeast (Sacchar [nrdb_11152004_Chlamydomonas] YCK1 SGDID:S000001177, Chr VIII from 374313-372697, reverse complement, Verified ORF, "Palmitoylated, plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking; pro [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] YCK1 SGDID:S000001177, Chr VIII from 374313-372697, reverse complement, Verified ORF, "Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking; prov [yeast-200209-contam.fasta] casein kinase I [nr-271106-contam.fasta] Palmitoylated, plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking; provides an essential function overlapping with that of Yck2p; Yck1p [Saccharomyces cerevi [nr-271106-contam.fasta] Yck1p: membrane-bound casein kinase I homolog [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Casein kinase I homolog 1 [nr-271106-contam.fasta] YCK1 SGDID:S000001177, Chr VIII from 374313-372697, reverse complement, Verified ORF, "Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking; provides an essential function overlapping with that of Yck2p" [yeast-bovrabprots.fasta] YCK1 SGDID:S000001177, Chr VIII from 374313-372697, reverse complement, Verified ORF, "Palmitoylated, plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking; provides an essential function overlapping with that of Yck2p" [yeast-contam_custom.fasta] [chemostatdb.fasta] Casein kinase I homolog 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YCK1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] YCK1 SGDID:S000001177, Chr VIII from 374310-372694, Genome Release 64-1-1, reverse complement, Verified ORF, "Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking; provides an essential function overlapping with that of Yck2p" [yeast-030211-contam.fasta] YCK1 SGDID:S000001177, Chr VIII from 374310-372694, Genome Release 64-2-1, reverse complement, Verified ORF, "Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking, and glucose sensing; stabilized by Sod1p binding in the presence of glucose and oxygen, causing glucose repression of respiratory metabolism; YCK1 has a paralog, YCK2, that arose from the whole genome duplication" [20141208_orf_trans.fasta] YHR135C SGDID:S000001177, Chr VIII from 374310-372694, Genome Release 64-1-1, reverse complement, Verified ORF, "Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking; provides an essential function overlapping with that of Yck2p" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	538 amino acids
Gene Ontology:
Cellular Component:	mitochondrion [IDA] endoplasmic reticulum [IDA] plasma membrane [IDA ]
Biological Process:	response to glucose stimulus [IMP] cell morphogenesis [IGI] cytokinesis [IGI] protein amino acid phosphorylation [IMP][ISS] endocytosis [IGI]
Molecular Function:	casein kinase I activity [IMP][ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSMPIASTTL AVNNLTNING NANFNVQANK QLHHQAVDSP ARSSMTATTA ANSNSNSSRD  60
   61 DSTIVGLHYK IGKKIGEGSF GVLFEGTNMI NGVPVAIKFE PRKTEAPQLR DEYKTYKILN 120
  121 GTPNIPYAYY FGQEGLHNIL VIDLLGPSLE DLFDWCGRKF SVKTVVQVAV QMITLIEDLH 180
  181 AHDLIYRDIK PDNFLIGRPG QPDANNIHLI DFGMAKQYRD PKTKQHIPYR EKKSLSGTAR 240
  241 YMSINTHLGR EQSRRDDMEA LGHVFFYFLR GHLPWQGLKA PNNKQKYEKI GEKKRSTNVY 300
  301 DLAQGLPVQF GRYLEIVRSL SFEECPDYEG YRKLLLSVLD DLGETADGQY DWMKLNDGRG 360
  361 WDLNINKKPN LHGYGHPNPP NEKSRKHRNK QLQMQQLQMQ QLQQQQQQQQ YAQKTEADMR 420
  421 NSQYKPKLDP TSYEAYQHQT QQKYLQEQQK RQQQQKLQEQ QLQEQQLQQQ QQQQQQLRAT 480
  481 GQPPSQPQAQ TQSQQFGARY QPQQQPSAAL RTPEQHPNDD NSSLAASHKG FFQKLGCC

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		YCK1 YCK2
View Details	(MIPS) Mewes HW, et al. (2004)		HRR25 YCK1 YCK2 YCK3
View Details	Ho Y, et al. (2002)		AAC3 ADH2 AHP1 APC1 BCY1 CAR2 CYS4 FOL2 GND1 GTO1 HYP2 ILV5 LAA1 LYS1 MPC54 OYE2 OYE3 PDC5 POR1 PPH21 PPH22 PST2 PYC2 SAH1 SNO2 SOD1 SSN8 THI21 THI22 THO2 TIF1, TIF2 TMA29 TPD3 TPK2 TPK3 UBA1 VPS21 YBL108W YBR028C YCK1 YCK2 YCK3 YGR111W YHR112C YPT53
View Details	Qiu et al. (2008)		HRR25 YCK1 YCK2

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	MLP2	#29 Asynchronous Prep5-TiO2 Flowthrough	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	YCK1	DMA2	2	Uetz P, et al. (2000)
View Screen	YCK1	YER079W	2	Uetz P, et al. (2000)
View Screen	YCK1	SIP2	2	Unpublished Fields Lab Data
View Screen	YCK1	DUN1	2	Uetz P, et al. (2000)

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	YCK1	Huh WK, et al. (2003)

Protein Structure Data

[What does the above image mean?]
[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..111] [128..143]	PSI-BLAST	1277.0	Casein kinase-1, CK1
2	View Details	[112..127] [144..149] [174..226]	PSI-BLAST	1277.0	Casein kinase-1, CK1
3	View Details	[150..173] [227..416]	PSI-BLAST	1277.0	Casein kinase-1, CK1
4	View Details	[417..538]	deduced	N/A	No confident structure predictions are available.

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
phosphotransferase activity, alcohol group as acceptor	5.49988294224815	bayes_pls_golite062009
protein kinase activity	5.4586557943719	bayes_pls_golite062009
kinase activity	5.3287080791198	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	4.96052051118534	bayes_pls_golite062009
protein serine/threonine kinase activity	4.46381887831481	bayes_pls_golite062009
transferase activity	3.97138602499442	bayes_pls_golite062009
protein tyrosine kinase activity	2.8153155526437	bayes_pls_golite062009
binding	2.74863538127007	bayes_pls_golite062009
transmembrane receptor activity	2.59526003830791	bayes_pls_golite062009
transmembrane receptor protein kinase activity	2.54265774272269	bayes_pls_golite062009
molecular transducer activity	2.40586892801446	bayes_pls_golite062009
signal transducer activity	2.40586892801446	bayes_pls_golite062009
receptor activity	2.39311927684508	bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity	2.16831387024372	bayes_pls_golite062009
receptor signaling protein activity	2.10379226653669	bayes_pls_golite062009
ATP binding	1.97600611746091	bayes_pls_golite062009
adenyl ribonucleotide binding	1.93596671856664	bayes_pls_golite062009
adenyl nucleotide binding	1.90928021591891	bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity	1.81249386965144	bayes_pls_golite062009
purine ribonucleotide binding	1.65732943334212	bayes_pls_golite062009
ribonucleotide binding	1.65726906484847	bayes_pls_golite062009
purine nucleotide binding	1.63763394711025	bayes_pls_golite062009
nucleotide binding	1.63195828048121	bayes_pls_golite062009
protein binding	1.22565748038754	bayes_pls_golite062009
catalytic activity	1.21655087018101	bayes_pls_golite062009
transporter activity	1.11833481501707	bayes_pls_golite062009
transmembrane transporter activity	0.97575992765505	bayes_pls_golite062009
growth factor binding	0.86076618871384	bayes_pls_golite062009
nucleic acid binding	0.794058505655489	bayes_pls_golite062009
transcription regulator activity	0.775404673285876	bayes_pls_golite062009
DNA binding	0.714163549867672	bayes_pls_golite062009
transcription factor activity	0.563262875317016	bayes_pls_golite062009
peptidase activity	0.540289770145252	bayes_pls_golite062009
cyclin-dependent protein kinase activity	0.499492353295369	bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity	0.48345772948903	bayes_pls_golite062009
substrate-specific transporter activity	0.451090007290896	bayes_pls_golite062009
protein kinase C activity	0.41587987561486	bayes_pls_golite062009
magnesium ion binding	0.393328812780268	bayes_pls_golite062009
MAP kinase kinase kinase activity	0.37115026509016	bayes_pls_golite062009
MAP kinase kinase activity	0.35402045013148	bayes_pls_golite062009
kinase binding	0.26752427107238	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	0.265003282584135	bayes_pls_golite062009
MAP kinase activity	0.26024936404169	bayes_pls_golite062009
protein complex binding	0.239339759110451	bayes_pls_golite062009
transforming growth factor beta receptor activity	0.20643152368029	bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase activity	0.20643152368029	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.205652638854091	bayes_pls_golite062009
receptor binding	0.197402253061255	bayes_pls_golite062009
protein kinase binding	0.00674998152095019	bayes_pls_golite062009

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.92

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2