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Protein Overview: TFG1

General Information:
Name(s) found: TFG1 / YGR186W [SGD]
Description(s) found:
Found 28 descriptions.
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  • TFIIF (Transcription Factor II) largest subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP74 [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 735 amino acids

    Gene Ontology:
    Cellular Component: transcription factor TFIIF complex [TASLink to PubMed article]
    Biological Process: transcription initiation from RNA polymerase II promoter [TASLink to PubMed articleLink to PubMed article]
    Molecular Function: general RNA polymerase II transcription factor activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRRNPPGSR NGGGPTNASP FIKRDRMRRN FLRMRMGQNG SNSSSPGVPN GDNSRGSLVK  60
   61 KDDPEYAEER EKMLLQIGVE ADAGRSNVKV KDEDPNEYNE FPLRAIPKED LENMRTHLLK 120
  121 FQSKKKINPV TDFHLPVRLH RKDTRNLQFQ LTRAEIVQRQ KEISEYKKKA EQERSTPNSG 180
  181 GMNKSGTVSL NNTVKDGSQT PTVDSVTKDN TANGVNSSIP TVTGSSVPPA SPTTVSAVES 240
  241 NGLSNGSTSA ANGLDGNAST ANLANGRPLV TKLEDAGPAE DPTKVGMVKY DGKEVTNEPE 300
  301 FEEGTMDPLA DVAPDGGGRA KRGNLRRKTR QLKVLDENAK KLRFEEFYPW VMEDFDGYNT 360
  361 WVGSYEAGNS DSYVLLSVED DGSFTMIPAD KVYKFTARNK YATLTIDEAE KRMDKKSGEV 420
  421 PRWLMKHLDN IGTTTTRYDR TRRKLKAVAD QQAMDEDDRD DNSEVELDYD EEFADDEEAP 480
  481 IIDGNEQENK ESEQRIKKEM LQANAMGLRD EEAPSENEED ELFGEKKIDE DGERIKKALQ 540
  541 KTELAALYSS DENEINPYLS ESDIENKENE SPVKKEEDSD TLSKSKRSSP KKQQKKATNA 600
  601 HVHKEPTLRV KSIKNCVIIL KGDKKILKSF PEGEWNPQTT KAVDSSNNAS NTVPSPIKQE 660
  661 EGLNSTVAER EETPAPTITE KDIIEAIGDG KVNIKEFGKF IRRKYPGAEN KKLMFAIVKK 720
  721 LCRKVGNDHM ELKKE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) DST1 IWR1 RPB10 RPB11 RPB2 RPB3 RPB4 RPB5 RPB7 RPB8 RPB9 RPC10 RPO21 RPO26 SPT4 SPT5 TAF14 TFG1 TFG2
    View Details (MIPS) Mewes HW, et al. (2004) TAF14 TFG1 TFG2
    View Details Krogan NJ, et al. (2006) ALG3 BUD27 CBF2 DST1 ESS1 IWR1 RPB10 RPB11 RPB2 RPB3 RPB4 RPB5 RPB7 RPB8 RPB9 RPO21 RPO26 SPT4 TAF14 TFG1 TFG2 YBL059W YBR259W YPL225W
    View Details Gavin AC, et al. (2006) IWR1 RPB11 RPB2 RPB3 RPB4 RPB7 RPB9 TFG1 TFG2
    View Details Gavin AC, et al. (2002) ABD1 AOS1 IWR1 RPB11 RPB2 RPB3 RPB4 RPB5 RPB7 RPB8 RPB9 RPO21 RPO26 SPT4 SPT5 TAF14 TFG1 TFG2
    View Details Ho Y, et al. (2002) BCY1 CAR2 CPR6 ESS1 HEF3 HSP104 HXT6 MDN1 PUP2 RPB3 RPN1 RPO21 SPT5 TFG1 TOM1 UTP22 YHR033W
    View Details Qiu et al. (2008) CDC73 NUT2 RPB10 RPB4 RPO26 SRB7 TAF10 TAF12 TAF14 TAF2 TFB5 TFG1 TFG2 TOA2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CAB3 No Comments Hazbun TR, et al. (2003)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data TFG1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..127] deduced N/A No confident structure predictions are available.
    2 View Details [128..346] MSA 1.004997 View MSA. No confident structure predictions are available.
    3 View Details [347..735] deduced N/A No confident structure predictions are available.
    4 View Details [552..606] deduced N/A No confident structure predictions are available.
    5 View Details [607..735] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • general RNA polymerase II transcription factor activity
    		•  9.80911813987926 bayes_pls_golite062009
  • transcription initiation factor activity
    		•  5.81303336834294 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.74982553633054 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.72386143594717 bayes_pls_golite062009
  • binding
    		•  2.67974220661654 bayes_pls_golite062009
  • transcription coactivator activity
    		•  1.13156484215109 bayes_pls_golite062009
  • protein binding
    		•  1.02443871942815 bayes_pls_golite062009
  • transcription activator activity
    		•  0.71834071764197 bayes_pls_golite062009
  • transcription factor binding
    		•  0.590528155685771 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.322693099994972 bayes_pls_golite062009
  • catalytic activity
    		•  0.315768210630189 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle