YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: TRR1

General Information:
Name(s) found: TRR1 / YDR353W [SGD]
Description(s) found:
Found 33 descriptions.
SHOW ALL
  • Cytoplasmic thioredoxin reductase, key regulatory enzyme that determines the redox state of the thioredoxin system, which acts as a disulfide reductase system and protects cells against both oxidative and reductive stress [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 319 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [TASLink to PubMed article]
    Biological Process: response to oxidative stress [IGILink to PubMed article]
    Molecular Function: thioredoxin-disulfide reductase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVHNKVTIIG SGPAAHTAAI YLARAEIKPI LYEGMMANGI AAGGQLTTTT EIENFPGFPD  60
   61 GLTGSELMDR MREQSTKFGT EIITETVSKV DLSSKPFKLW TEFNEDAEPV TTDAIILATG 120
  121 ASAKRMHLPG EETYWQKGIS ACAVCDGAVP IFRNKPLAVI GGGDSACEEA QFLTKYGSKV 180
  181 FMLVRKDHLR ASTIMQKRAE KNEKIEILYN TVALEAKGDG KLLNALRIKN TKKNEETDLP 240
  241 VSGLFYAIGH TPATKIVAGQ VDTDEAGYIK TVPGSSLTSV PGFFAAGDVQ DSKYRQAITS 300
  301 AGSGCMAALD AEKYLTSLE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) TRR1 TRR2
    View Details Krogan NJ, et al. (2006) TRR1 TRR2
    View Details Ho Y, et al. (2002) AAT2 ACS2 ADE3 ADE6 ADH4 ADO1 ALA1 APE2 ARA1 ARG4 BAT1 CAF120 CAR2 CDC10 CDC60 CLU1 CPR1 CPR6 CYS3 DED81 DPS1 ENP1 ERG10 ERG20 GCY1 GPH1 GRS1 GSP2 HOM2 HYP2 ILS1 IMD3 KRS1 LSP1 MDH1 MDH3 MPC54 NAS6 OLA1 OYE2 PAB1 PDC5 PFK2 PGM2 PMI40 PRP6 QNS1 RHO5 SAC6 SCP160 SOD1 SSZ1 SUI1 THR4 TPS1 TRR1 UBA1 YDL124W YGK3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen RPN9 TRR1 1 Unpublished Fields Lab Data
    View Screen APC5 TRR1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data TRR1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..123]
    [250..319]    		 PSI-BLAST 1161.09691 Thioredoxin reductase
    2 View Details [124..249] PSI-BLAST 1161.09691 Thioredoxin reductase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • thioredoxin-disulfide reductase activity
    		•  3.42654162439464 bayes_pls_golite062009
  • antioxidant activity
    		•  3.37477730756688 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors
    		•  3.17769237742078 bayes_pls_golite062009
  • catalytic activity
    		•  1.56773888754354 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor
    		•  1.45104542724719 bayes_pls_golite062009
  • binding
    		•  1.4227698123368 bayes_pls_golite062009
  • oxidoreductase activity
    		•  0.44090433301056 bayes_pls_golite062009
  • oxygen-dependent protoporphyrinogen oxidase activity
    		•  0.1498172520052 bayes_pls_golite062009
  • dihydrolipoyl dehydrogenase activity
    		•  0.130601418359425 bayes_pls_golite062009
  • protein binding
    		•  0.116927178396589 bayes_pls_golite062009
  • disulfide oxidoreductase activity
    		•  0.0160065137614933 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.56

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle