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Protein Overview: RAD59

General Information:
Name(s) found: RAD59 / YDL059C [SGD]
Description(s) found:
Found 28 descriptions.
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  • Protein involved in the repair of double-strand breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; homologous to Rad52p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 238 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IGILink to PubMed article]
    Biological Process: double-strand break repair via break-induced replication [TASLink to PubMed article]
    double-strand break repair via single-strand annealing [IGILink to PubMed article]
    telomere maintenance via recombination [IMPLink to PubMed article]
    Molecular Function: protein binding [IPILink to PubMed article]
    DNA strand annealing activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTIQAKPSSS ISYDSTTYGT APGLDIKEFQ IIEDWNGRPA SAWSVQRIGL LQSKIERYTY  60
   61 NIYHNNKYGK HNLSKLIPGH ALIQFANETF GYDGWRMDVI DVEARECQPF TAVNNGENTN 120
  121 TSEVKYTVVA EAQVKVTLKD GTNTQCGGLG RITLSSRGEC YNRSKKEAVG DALKKALLSF 180
  181 EKIILDYETK ITNNYYVDGL YGSKKIKNEA NTNYNLLSAT NSKPTFIKLE DAKGTHIK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ADA2 AHC1 AHC2 FMP40 GCN5 HFI1 MSS4 NGG1 PDR15 RAD59 REV3 SGF11 SGF29 SGF73 SNL1 SPT20 SPT3 SPT7 SPT8 TAF1 TAF10 TAF11 TAF12 TAF13 TAF3 TAF4 TAF5 TAF6 TAF7 TAF9 UBP8 YMR007W
    View Details Ho Y, et al. (2002) AAC3 AHA1 ATP3 BEM2 ECM10 GCD11 HOM3 HOR2 ILV2 NTG1 OPY1 OYE2 PGM1 PGM2 PIL1 PRB1 PTC3 RAD52 RAD59 RHR2 RPB3 RPT3 SEC27 SEC53 TEF4 UBA1 VMA8 YER138C YPT31

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen VPS5 RAD59 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data RAD59 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..173] MSA 2.017967 View MSA. No confident structure predictions are available.
    2 View Details [174..238] deduced N/A Confident ab initio structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  3.09705138687537 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.62582371207063 bayes_pls_golite062009
  • RNA binding
    		•  1.51047378734681 bayes_pls_golite062009
  • protein binding
    		•  1.33336414936007 bayes_pls_golite062009
  • DNA binding
    		•  1.09648705416581 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.558060375765317 bayes_pls_golite062009
  • double-stranded RNA binding
    		•  0.33006862628358 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.109630981204183 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle