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View Structure Prediction Details

Protein: RAD59
Organism: Saccharomyces cerevisiae
Length: 238 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RAD59.

Description E-value Query
Range
Subject
Range
RAD59 - Protein involved in the repair of double-strand breaks in DNA during vegetative growth via recombina...
gi|190405069 - gi|190405069|gb|EDV08336.1| DNA repair protein RAD59 [Saccharomyces cerevisiae RM11-1a]
RAD59_YEAST - DNA repair protein RAD59 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RAD59 PE=1 SV=1
4.0E-99 [1..238] [1..238]
RAD59_KLULA, RA5... - DNA repair protein RAD59 OS=Kluyveromyces lactis GN=RAD59 PE=3 SV=1, (Q9HEU2) DNA repair protein RAD...
RAD59_KLULA - DNA repair protein RAD59 OS=Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 126...
1.0E-76 [9..213] [5..203]
gi|6755280, gi|1... - gi|6755280|ref|NP_035366.1| RAD52 homolog [Mus musculus], gi|458458|gb|AAA75441.1| homology to Swiss...
2.0E-70 [41..226] [30..197]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
2.0E-70 [41..226] [30..197]
gi|6716781 - gi|6716781|gb|AAF26740.1|AF220495_1 Rad52 recombination protein [Cricetulus griseus]
1.0E-69 [41..226] [30..197]
RAD22_SCHPO - DNA repair and recombination protein rad22 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN...
rad22 - DNA repair protein Rad22
4.0E-67 [41..230] [19..198]

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Predicted Domain #1
Region A:
Residues: [1-173]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTIQAKPSSS ISYDSTTYGT APGLDIKEFQ IIEDWNGRPA SAWSVQRIGL LQSKIERYTY  60
   61 NIYHNNKYGK HNLSKLIPGH ALIQFANETF GYDGWRMDVI DVEARECQPF TAVNNGENTN 120
  121 TSEVKYTVVA EAQVKVTLKD GTNTQCGGLG RITLSSRGEC YNRSKKEAVG DAL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
binding 3.09705138687537 bayes_pls_golite062009
nucleic acid binding 2.62582371207063 bayes_pls_golite062009
RNA binding 1.51047378734681 bayes_pls_golite062009
protein binding 1.33336414936007 bayes_pls_golite062009
DNA binding 1.09648705416581 bayes_pls_golite062009
transcription regulator activity 0.558060375765317 bayes_pls_golite062009
double-stranded RNA binding 0.33006862628358 bayes_pls_golite062009
structure-specific DNA binding 0.109630981204183 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [174-238]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KKALLSFEKI ILDYETKITN NYYVDGLYGS KKIKNEANTN YNLLSATNSK PTFIKLEDAK  60
   61 GTHIK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.825 0.036 DNA strand annealing activity d.50.1 dsRNA-binding domain-like


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle