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Protein Overview: PYC2

General Information:
Name(s) found: PYC2 / YBR218C [SGD]
Description(s) found:
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  • gi|6319695|ref|NP_009777.1| Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc1p but differentially regulated; mutations in the human homolog are associated with lactic acidosis; Pyc2p [S [NCBI NR]
  • pir||S46094 pyruvate carboxylase (EC 6.4.1.1) 2 - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|585765|sp|P32327.2|PYC2_YEAST RecName: Full=Pyruvate carboxylase 2; AltName: Full=Pyruvic carboxylase 2; Short=PCB 2 [NCBI NR]
  • gi|536608|emb|CAA85182.1| PYC2 [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1041735|gb|AAC49147.1| pyruvate carboxylase 2 [NCBI NR]
  • Pyruvate carboxylase 2 OS=Saccharomyces cerevisiae GN=PYC2 PE=1 SV=2 [Swiss-Prot]
  • PYC2 Pyruvate carboxylase 2 [mips]
  • Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc1p but differentially regulated; mutations in the human homolog are associated with lactic acidosis [SGD]
  • PYC2, Chr II from 658665-662207, reverse complement [yeast_orfs2]
  • Chr II from 658665-662207, reverse complement [yeastorf3.fasta]
  • Chr II from 658664-662206, reverse complement [yeastorf4.fasta]
  • Chr II from 662204-658662, reverse complement [yeastorf5.fasta]
  • (P32327) Pyruvate carboxylase 2 (EC 6.4.1.1) (Pyruvic carboxylase 2) (PCB 2) [4932.FASTACCERV.txt]
  • PYC2 SGDID:S0000422, Chr II from 662206-658664, reverse complement, Verified ORF [yeastflysequest.fasta]
  • PYC2 SGDID:S0000422, Chr II from 662244-658702, reverse complement, Verified ORF [10112005cervSGD.fasta]
  • Pyc2p [Saccharomyces cerevisiae]gi|536608|emb|CAA85182.1| PYC2 [Saccharomyces cerevisiae]gi|1041735|gb|AAC49147.1| pyruvate carboxylase 2gi|625438|pir||S46094 pyruvate carboxylase (EC 6.4.1.1) 2 - yeast (Saccharomyces cerevisiae)gi|585765|sp|P32327|PY [nrdb_11152004_Chlamydomonas]
  • PYC2 SGDID:S000000422, Chr II from 662244-658702, reverse complement, Verified ORF, "Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc1p but differentially regulated; mutations in the hu [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • Pyruvate carboxylase 2 (Pyruvic carboxylase 2) (PCB 2) [nr-271106-contam.fasta]
  • pyruvate carboxylase 2 [nr-271106-contam.fasta]
  • PYC2 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc1p but differentially regulated; mutations in the human homolog are associated with lactic acidosis; Pyc2p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • PYC2 SGDID:S000000422, Chr II from 662244-658702, reverse complement, Verified ORF, "Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc1p but differentially regulated; mutations in the human homolog are associated with lactic acidosis" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • Pyruvate carboxylase 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PYC2 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • PYC2 SGDID:S000000422, Chr II from 662249-658707, Genome Release 64-1-1, reverse complement, Verified ORF, "Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc1p but differentially regulated; mutations in the human homolog are associated with lactic acidosis" [yeast-030211-contam.fasta]
  • PYC2 SGDID:S000000422, Chr II from 662249-658707, Genome Release 64-2-1, reverse complement, Verified ORF, "Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc1p; mutations in the human homolog are associated with lactic acidosis; PYC2 has a paralog, PYC1, that arose from the whole genome duplication" [20141208_orf_trans.fasta]
  • YBR218C SGDID:S000000422, Chr II from 662249-658707, Genome Release 64-1-1, reverse complement, Verified ORF, "Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc1p but differentially regulated; mutations in the human homolog are associated with lactic acidosis" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
  • ID=asmbl_4794|g.3144 ORF ID=asmbl_4794|g.3144 ID=asmbl_4794|m.3144 type:complete len:1181 (+) ID=asmbl_4794:4240-7782(+) [DBVPG6044_quiverGenomes_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 1180 amino acids

    Gene Ontology:
    Cellular Component: cytosol [IDALink to PubMed articleLink to PubMed article]
    Biological Process: gluconeogenesis [IMPLink to PubMed article]
    NADPH regeneration [TAS]
    Molecular Function: pyruvate carboxylase activity [IDALink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSSKKLAGL RDNFSLLGEK NKILVANRGE IPIRIFRSAH ELSMRTIAIY SHEDRLSMHR  60
   61 LKADEAYVIG EEGQYTPVGA YLAMDEIIEI AKKHKVDFIH PGYGFLSENS EFADKVVKAG 120
  121 ITWIGPPAEV IDSVGDKVSA RHLAARANVP TVPGTPGPIE TVQEALDFVN EYGYPVIIKA 180
  181 AFGGGGRGMR VVREGDDVAD AFQRATSEAR TAFGNGTCFV ERFLDKPKHI EVQLLADNHG 240
  241 NVVHLFERDC SVQRRHQKVV EVAPAKTLPR EVRDAILTDA VKLAKVCGYR NAGTAEFLVD 300
  301 NQNRHYFIEI NPRIQVEHTI TEEITGIDIV SAQIQIAAGA TLTQLGLLQD KITTRGFSIQ 360
  361 CRITTEDPSK NFQPDTGRLE VYRSAGGNGV RLDGGNAYAG ATISPHYDSM LVKCSCSGST 420
  421 YEIVRRKMIR ALIEFRIRGV KTNIPFLLTL LTNPVFIEGT YWTTFIDDTP QLFQMVSSQN 480
  481 RAQKLLHYLA DLAVNGSSIK GQIGLPKLKS NPSVPHLHDA QGNVINVTKS APPSGWRQVL 540
  541 LEKGPSEFAK QVRQFNGTLL MDTTWRDAHQ SLLATRVRTH DLATIAPTTA HALAGAFALE 600
  601 CWGGATFDVA MRFLHEDPWE RLRKLRSLVP NIPFQMLLRG ANGVAYSSLP DNAIDHFVKQ 660
  661 AKDNGVDIFR VFDALNDLEQ LKVGVNAVKK AGGVVEATVC YSGDMLQPGK KYNLDYYLEV 720
  721 VEKIVQMGTH ILGIKDMAGT MKPAAAKLLI GSLRTRYPDL PIHVHSHDSA GTAVASMTAC 780
  781 ALAGADVVDV AINSMSGLTS QPSINALLAS LEGNIDTGIN VEHVRELDAY WAEMRLLYSC 840
  841 FEADLKGPDP EVYQHEIPGG QLTNLLFQAQ QLGLGEQWAE TKRAYREANY LLGDIVKVTP 900
  901 TSKVVGDLAQ FMVSNKLTSD DIRRLANSLD FPDSVMDFFE GLIGQPYGGF PEPLRSDVLR 960
  961 NKRRKLTCRP GLELEPFDLE KIREDLQNRF GDIDECDVAS YNMYPRVYED FQKIRETYGD1020
 1021 LSVLPTKNFL APAEPDEEIE VTIEQGKTLI IKLQAVGDLN KKTGQREVYF ELNGELRKIR1080
 1081 VADKSQNIQS VAKPKADVHD THQIGAPMAG VIIEVKVHKG SLVKKGESIA VLSAMKMEMV1140
 1141 VSSPADGQVK DVFIKDGESV DASDLLVVLE EETLPPSQKK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) PYC1 PYC2
    View Details Krogan NJ, et al. (2006) PYC1 PYC2 SPS1 TPM1
    View Details Ho Y, et al. (2002) AAC3 ACC1 ACH1 ADH2 ADR1 AHP1 CAR2 FOL2 GCD11 GFA1 GND1 GUS1 HYP2 IDH2 ILV5 ISA2 MDH1 MET18 MPC54 NGL2 OYE2 OYE3 POR1 PST2 PYC1 PYC2 RET1 RPA135 RPA190 RPA49 RPB5 RPC19 RPC25 RPC34 RPC40 RPC82 RPN3 RPO26 RPO31 RVS167 SEC27 SOD1 TBS1 TFP1 TSA2 YBL108W YCK1 YFL042C YHR112C
    View Details Qiu et al. (2008) PYC1 PYC2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run BOI1 Sample boi 1 with ha tag from october 2005 McCusker D, et al (2007)
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PYC2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..129] PSI-BLAST 1114.228787 No description for 1lsrA_ was found.
    2 View Details [130..136]
    [152..224]    		 PSI-BLAST 1114.228787 No description for 1lsrA_ was found.
    3 View Details [137..151]
    [225..250]
    [263..357]    		 PSI-BLAST 1114.228787 No description for 1lsrA_ was found.
    4 View Details [251..262]
    [358..475]    		 PSI-BLAST 1114.228787 No description for 1lsrA_ was found.
    5 View Details [476..536] deduced N/A No confident structure predictions are available.
    6 View Details [537..701] ORFEUS 9.05 Betaine-homocysteine S-methyltransferase
    7 View Details [702..932] ORFEUS 9.79 Dihydrodipicolinate synthase
    8 View Details [933..992] ORFEUS 9.79 Dihydrodipicolinate synthase
    9 View Details [993..1086] deduced N/A No confident structure predictions are available.
    10 View Details [1087..1180] PSI-BLAST 86.39794 Biotin carboxyl carrier domain of transcarboxylase (TC 1.3S)


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle