YRC Public Data Repository - Protein Structure Prediction

Protein:	PYC2
Organism:	Saccharomyces cerevisiae
Length:	1180 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PYC2.

Description	E-value	Query Range	Subject Range
PYC_PICPA - Pyruvate carboxylase OS=Komagataella pastoris GN=PYC1 PE=3 SV=1	0.0	[4..1166]	[6..1170]
gi\|215404942 - gi\|215404942\|ref\|ZP_03417123.1\| pyruvate carboxylase [Mycobacterium tuberculosis 02_1987] gi\|215428417 - gi\|215428417\|ref\|ZP_03426336.1\| pyruvate carboxylase [Mycobacterium tuberculosis T92] gi\|215431916 - gi\|215431916\|ref\|ZP_03429835.1\| pyruvate carboxylase [Mycobacterium tuberculosis EAS054] gi\|31794143, gi\|... - gi\|31794143\|ref\|NP_856636.1\| pyruvate carboxylase [Mycobacterium bovis AF2122/97], gi\|31619738\|emb\|C... gi\|148824157, gi... - gi\|76783442\|ref\|ZP_00770634.1\| COG1038: Pyruvate carboxylase [Mycobacterium tuberculosis F11], gi\|14... gi\|7438126 - pir\|\|D70671 pyruvate carboxylase (EC 6.4.1.1) - Mycobacterium tuberculosis (strain H37RV) gi\|81253032, gi\|... - gi\|81253032\|ref\|ZP_00877600.1\| COG1038: Pyruvate carboxylase [Mycobacterium tuberculosis C], gi\|2542... gi\|255097796 - gi\|255097796\|ref\|ZP_05327274.1\| pyruvate carboxylase [Mycobacterium tuberculosis KZN 605] gi\|254816813 - gi\|254816813\|ref\|ZP_05221814.1\| pyruvate carboxylase [Mycobacterium tuberculosis KZN 4207] gi\|254552044 - gi\|254552044\|ref\|ZP_05142491.1\| pyruvate carboxylase [Mycobacterium tuberculosis '98-R604 INH-RIF-EM... gi\|121638848, gi... - gi\|121638848\|ref\|YP_979072.1\| pyruvate carboxylase [Mycobacterium bovis BCG str. Pasteur 1173P2], gi... gi\|253319444, gi... - gi\|253797941\|ref\|YP_003030942.1\| pyruvate carboxylase pca [Mycobacterium tuberculosis KZN 1435], gi\|... gi\|134151117, gi... - gi\|254365604\|ref\|ZP_04981649.1\| pyruvate carboxylase pca [Mycobacterium tuberculosis str. Haarlem], ... gi\|13882829, gi\|... - gi\|15842520\|ref\|NP_337557.1\| pyruvate carboxylase [Mycobacterium tuberculosis CDC1551], gi\|13882829\|... gi\|15610104, gi\|... - gi\|1694864\|emb\|CAB05410.1\| PROBABLE PYRUVATE CARBOXYLASE PCA (PYRUVIC CARBOXYLASE) [Mycobacterium tu... gi\|148506967, gi... - gi\|148662815\|ref\|YP_001284338.1\| pyruvate carboxylase [Mycobacterium tuberculosis H37Ra], gi\|1485069... gi\|215447234 - gi\|215447234\|ref\|ZP_03433986.1\| pyruvate carboxylase [Mycobacterium tuberculosis T85] gi\|218754727 - gi\|218754727\|ref\|ZP_03533523.1\| pyruvate carboxylase [Mycobacterium tuberculosis GM 1503] gi\|219558997 - gi\|219558997\|ref\|ZP_03538073.1\| pyruvate carboxylase [Mycobacterium tuberculosis T17] gi\|224774455, gi... - gi\|224991340\|ref\|YP_002646029.1\| pyruvate carboxylase [Mycobacterium bovis BCG str. Tokyo 172], gi\|2...	0.0	[19..1169]	[1..1126]
PYC_PICAN - Pyruvate carboxylase OS=Pichia angusta GN=PYC PE=3 SV=1 PYC_PICAN - Pyruvate carboxylase OS=Pichia angusta GN=PYC PE=3 SV=1	0.0	[1..1169]	[1..1173]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[2..1170]	[19..1178]
gi\|25293930 - pir\|\|A83978 pyruvate carboxylase pycA [imported] - Bacillus halodurans (strain C-125) gi\|10175246, gi\|... - gi\|15615188\|ref\|NP_243491.1\| pyruvate carboxylase [Bacillus halodurans C-125], gi\|10175246\|dbj\|BAB06...	0.0	[20..1171]	[7..1149]
PC - pyruvate carboxylase	0.0	[2..1170]	[19..1178]
gi\|16800129 - gi\|16800129\|ref\|NP_470397.1\| pyruvate carboxylase [Listeria innocua Clip11262] gi\|25293933, gi\|... - pir\|\|AC1565 pyruvate carboxylase homolog pycA [imported] - Listeria innocua (strain Clip11262), gi\|1...	0.0	[17..1169]	[1..1143]
gi\|18858695, gi\|... - gi\|18858695\|ref\|NP_571625.1\| pyruvate carboxylase [Danio rerio], gi\|11545421\|gb\|AAG37836.1\|AF295372_...	0.0	[19..1171]	[38..1180]
gi\|269202726\|ref... - pyruvate carboxylase [Staphylococcus aureus subsp. aureus ED98] gi\|25293932 - pir\|\|G89881 pyruvate carboxylase [imported] - Staphylococcus aureus (strain N315) gi\|156721572, gi... - gi\|156979437\|ref\|YP_001441696.1\| pyruvate carboxylase [Staphylococcus aureus subsp. aureus Mu3], gi\|... gi\|90587124, gi\|... - gi\|90587124\|ref\|ZP_01242798.1\| Pyruvate carboxylase [Staphylococcus aureus subsp. aureus JH9], gi\|90... gi\|149946114, gi... - gi\|90584339\|ref\|ZP_01240075.1\| Pyruvate carboxylase [Staphylococcus aureus subsp. aureus JH1], gi\|90... gi\|255005901 - gi\|255005901\|ref\|ZP_05144502.2\| pyruvate carboxylase [Staphylococcus aureus subsp. aureus Mu50-omega... gi\|253316745 - gi\|253316745\|ref\|ZP_04839958.1\| pyruvate carboxylase [Staphylococcus aureus subsp. aureus str. CF-Ma... gi\|242556709, gi... - gi\|242556710\|pdb\|3HO8\|B Chain B, Crystal Structure Of S. Aureus Pyruvate Carboxylase In Complex With... gi\|13700915, gi\|... - gi\|15926699\|ref\|NP_374232.1\| pyruvate carboxylase [Staphylococcus aureus subsp. aureus N315], gi\|137...	0.0	[17..1174]	[1..1150]
gi\|25293937 - pir\|\|AE3285 pyruvate carboxylase (EC 6.4.1.1) [imported] - Brucella melitensis (strain 16M) gi\|17986550, gi\|... - gi\|17986550\|ref\|NP_539184.1\| pyruvate carboxylase [Brucella melitensis 16M], gi\|17982157\|gb\|AAL51448...	0.0	[18..1171]	[6..1158]

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Predicted Domain #1

Region A:
Residues: [1-129]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSSKKLAGL RDNFSLLGEK NKILVANRGE IPIRIFRSAH ELSMRTIAIY SHEDRLSMHR  60
   61 LKADEAYVIG EEGQYTPVGA YLAMDEIIEI AKKHKVDFIH PGYGFLSENS EFADKVVKAG 120
  121 ITWIGPPAE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1114.228787
Match:	1lsrA_
Description:	No description for 1lsrA_ was found.

Predicted Domain #2

Region A:
Residues: [130-136]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VIDSVGD

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [152-224]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VPGTPGPIET VQEALDFVNE YGYPVIIKAA FGGGGRGMRV VREGDDVADA FQRATSEART  60
   61 AFGNGTCFVE RFL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1114.228787
Match:	1lsrA_
Description:	No description for 1lsrA_ was found.

Predicted Domain #3

Region A:
Residues: [137-151]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KVSARHLAAR ANVPT

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [225-250]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DKPKHIEVQL LADNHGNVVH LFERDC

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [263-357]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 APAKTLPREV RDAILTDAVK LAKVCGYRNA GTAEFLVDNQ NRHYFIEINP RIQVEHTITE  60
   61 EITGIDIVSA QIQIAAGATL TQLGLLQDKI TTRGF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1114.228787
Match:	1lsrA_
Description:	No description for 1lsrA_ was found.

Predicted Domain #4

Region A:
Residues: [251-262]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SVQRRHQKVV EV

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [358-475]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SIQCRITTED PSKNFQPDTG RLEVYRSAGG NGVRLDGGNA YAGATISPHY DSMLVKCSCS  60
   61 GSTYEIVRRK MIRALIEFRI RGVKTNIPFL LTLLTNPVFI EGTYWTTFID DTPQLFQM

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1114.228787
Match:	1lsrA_
Description:	No description for 1lsrA_ was found.

Predicted Domain #5

Region A:
Residues: [476-536]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VSSQNRAQKL LHYLADLAVN GSSIKGQIGL PKLKSNPSVP HLHDAQGNVI NVTKSAPPSG  60
   61 W

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6

Region A:
Residues: [537-701]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RQVLLEKGPS EFAKQVRQFN GTLLMDTTWR DAHQSLLATR VRTHDLATIA PTTAHALAGA  60
   61 FALECWGGAT FDVAMRFLHE DPWERLRKLR SLVPNIPFQM LLRGANGVAY SSLPDNAIDH 120
  121 FVKQAKDNGV DIFRVFDALN DLEQLKVGVN AVKKAGGVVE ATVCY

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	9.05
Match:	1lt7A
Description:	Betaine-homocysteine S-methyltransferase
Matching Structure (courtesy of the PDB):

Predicted Domain #7

Region A:
Residues: [702-932]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SGDMLQPGKK YNLDYYLEVV EKIVQMGTHI LGIKDMAGTM KPAAAKLLIG SLRTRYPDLP  60
   61 IHVHSHDSAG TAVASMTACA LAGADVVDVA INSMSGLTSQ PSINALLASL EGNIDTGINV 120
  121 EHVRELDAYW AEMRLLYSCF EADLKGPDPE VYQHEIPGGQ LTNLLFQAQQ LGLGEQWAET 180
  181 KRAYREANYL LGDIVKVTPT SKVVGDLAQF MVSNKLTSDD IRRLANSLDF P

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	9.79
Match:	1dhpA
Description:	Dihydrodipicolinate synthase
Matching Structure (courtesy of the PDB):

Predicted Domain #8

Region A:
Residues: [933-992]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DSVMDFFEGL IGQPYGGFPE PLRSDVLRNK RRKLTCRPGL ELEPFDLEKI REDLQNRFGD  60
   61

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	9.79
Match:	1dhpA
Description:	Dihydrodipicolinate synthase
Matching Structure (courtesy of the PDB):

Predicted Domain #9

Region A:
Residues: [993-1086]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IDECDVASYN MYPRVYEDFQ KIRETYGDLS VLPTKNFLAP AEPDEEIEVT IEQGKTLIIK  60
   61 LQAVGDLNKK TGQREVYFEL NGELRKIRVA DKSQ

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #10

Region A:
Residues: [1087-1180]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NIQSVAKPKA DVHDTHQIGA PMAGVIIEVK VHKGSLVKKG ESIAVLSAMK MEMVVSSPAD  60
   61 GQVKDVFIKD GESVDASDLL VVLEEETLPP SQKK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	86.39794
Match:	1dczA_
Description:	Biotin carboxyl carrier domain of transcarboxylase (TC 1.3S)
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits