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Protein Overview: CYS3

General Information:
Name(s) found: CYS3 / YAL012W [SGD]
Description(s) found:
Found 26 descriptions.
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  • Cystathionine gamma-lyase, catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 394 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: sulfur amino acid metabolic process [TASLink to PubMed article]
    response to drug [IMPLink to PubMed article]
    transsulfuration [TASLink to PubMed article]
    cysteine metabolic process [TASLink to PubMed article]
    Molecular Function: cystathionine gamma-lyase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTLQESDKFA TKAIHAGEHV DVHGSVIEPI SLSTTFKQSS PANPIGTYEY SRSQNPNREN  60
   61 LERAVAALEN AQYGLAFSSG SATTATILQS LPQGSHAVSI GDVYGGTHRY FTKVANAHGV 120
  121 ETSFTNDLLN DLPQLIKENT KLVWIETPTN PTLKVTDIQK VADLIKKHAA GQDVILVVDN 180
  181 TFLSPYISNP LNFGADIVVH SATKYINGHS DVVLGVLATN NKPLYERLQF LQNAIGAIPS 240
  241 PFDAWLTHRG LKTLHLRVRQ AALSANKIAE FLAADKENVV AVNYPGLKTH PNYDVVLKQH 300
  301 RDALGGGMIS FRIKGGAEAA SKFASSTRLF TLAESLGGIE SLLEVPAVMT HGGIPKEARE 360
  361 ASGVFDDLVR ISVGIEDTDD LLEDIKQALK QATN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) CYS3 IPL1 RAX2 SER1 UBA1 YDR415C YER156C
    View Details Gavin AC, et al. (2006) CYS3 RNA1
    View Details Gavin AC, et al. (2002) ADE4 CYS3 RNA1
    View Details Ho Y, et al. (2002) ACS2 ADE3 ADE6 ADO1 ALA1 APE2 ARA1 ATG5 BAT1 CDC10 CLU1 CYS3 DED81 DPS1 ERG10 ERG20 FET3 GCY1 GPH1 GRS1 HOM2 HYP2 ILS1 IMD3 KRS1 LSP1 MDH3 OLA1 PAB1 PFK2 PGM2 PMI40 PRP6 SAC6 SCP160 SOD1 SSZ1 THR4 TRR1 UBA1 YDL124W

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run ASF1 3912: TAP-tagged, strain background includes hpc2(delta) Green EM, et al (2005)
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #04 Alpha Factor Prep2 Keck JM, et al. (2011)
    View Run MLP2 #14 Mitotic Prep2-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #02 Alpha Factor Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen UBP6 CYS3 2 Unpublished Fields Lab Data
    View Screen RED1 CYS3 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data CYS3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..258]
    [291..305]    		 PSI-BLAST 896.228787 Methionine gamma-lyase, MGL
    2 View Details [259..290]
    [306..394]    		 PSI-BLAST 896.228787 Methionine gamma-lyase, MGL

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor
    		•  2.82824364293374 bayes_pls_golite062009
  • glycine dehydrogenase (decarboxylating) activity
    		•  2.82824364293374 bayes_pls_golite062009
  • catalytic activity
    		•  2.29878871754893 bayes_pls_golite062009
  • L-aspartate:2-oxoglutarate aminotransferase activity
    		•  1.87460342369605 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.67701710033155 bayes_pls_golite062009
  • DNA binding
    		•  1.4774443071095 bayes_pls_golite062009
  • transferase activity
    		•  1.44093490824786 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.39741122443159 bayes_pls_golite062009
  • transferase activity, transferring nitrogenous groups
    		•  1.28316822767388 bayes_pls_golite062009
  • transaminase activity
    		•  1.24990480711889 bayes_pls_golite062009
  • transcription factor activity
    		•  1.15775909410582 bayes_pls_golite062009
  • binding
    		•  1.09053123792737 bayes_pls_golite062009
  • O-phospho-L-serine:2-oxoglutarate aminotransferase activity
    		•  0.994935084630764 bayes_pls_golite062009
  • ligase activity
    		•  0.827063849687833 bayes_pls_golite062009
  • carbon-sulfur lyase activity
    		•  0.698312655247044 bayes_pls_golite062009
  • cystathionine beta-lyase activity
    		•  0.6849039330512 bayes_pls_golite062009
  • vitamin binding
    		•  0.66463470119531 bayes_pls_golite062009
  • cystathionine gamma-lyase activity
    		•  0.505859361763689 bayes_pls_golite062009
  • alanine-glyoxylate transaminase activity
    		•  0.48682493494502 bayes_pls_golite062009
  • O-acyltransferase activity
    		•  0.452440867878365 bayes_pls_golite062009
  • cysteine synthase activity
    		•  0.417849187928985 bayes_pls_golite062009
  • structural molecule activity
    		•  0.347975812448725 bayes_pls_golite062009
  • glycine hydroxymethyltransferase activity
    		•  0.271623203801431 bayes_pls_golite062009
  • pyridoxal phosphate binding
    		•  0.16957228630576 bayes_pls_golite062009
  • vitamin B6 binding
    		•  0.16957228630576 bayes_pls_golite062009
  • adenosylmethionine-8-amino-7-oxononanoate transaminase activity
    		•  0.0669652799570574 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle