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View Structure Prediction Details

Protein: let-60
Organism: Caenorhabditis elegans
Length: 184 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for let-60.

Description E-value Query
Range		 Subject
Range
RASH_MSVHA - Transforming protein p29 OS=Harvey murine sarcoma virus GN=H-RAS PE=1 SV=1
 194.0 [0..1] [184..53]
gi|54695710, gi|... - gi|61368178|gb|AAX43121.1| v-Ha-ras Harvey rat sarcoma viral oncogene-like [synthetic construct], gi...
 189.0 [0..1] [181..1]
gi|332198|gb|AAA... - p21 protein
gi|332198 - gi|332198|gb|AAA46574.1| p21 protein
RASH_MSVNS - GTPase HRas OS=Murine sarcoma virus NS.C58 GN=H-RAS PE=3 SV=1
RASH_MSVNS - (P23175) GTPase HRas precursor (Transforming protein p21/H-Ras)
 188.0 [0..1] [181..1]
gi|61559 - gi|61559|emb|CAA25322.1| transforming protein p21 [Murine sarcoma virus]
gi|61559|emb|CAA... - transforming protein p21 [Murine sarcoma virus]
 186.0 [0..1] [181..1]
gi|226746 - gi|226746|prf||1604384A ras oncogene
 184.0 [0..1] [181..1]
gi|333964 - gi|333964|gb|AAA47420.1| p29 transforming protein
RASH_RRASV - Transforming protein p29 OS=Rasheed rat sarcoma virus GN=RAS PE=3 SV=1
 184.0 [0..1] [181..60]
gi|939930 - gi|939930|emb|CAA80675.1| proto-oncogene protein [Kirsten murine sarcoma virus]
 183.0 [0..1] [184..1]
gi|303734, gi|738942 - gi|738942|prf||2001457K GTP-binding protein, gi|303734|dbj|BAA02118.1| GTP-binding protein [Pisum sa...
gi|1098293, gi|4... - pir||S41430 GTP-binding protein, ras-like (clone vfa-ypt1) - fava bean, gi|452359|emb|CAA82707.1| g...
 182.0 [0..4] [182..9]

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Predicted Domain #1
Region A:
Residues: [1-184] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTEYKLVVVG DGGVGKSALT IQLIQNHFVE EYDPTIEDSY RKQVVIDGET CLLDILDTAG  60
   61 QEEYSAMRDQ YMRTGEGFLL VFAVNEAKSF ENVANYREQI RRVKDSDDVP MVLVGNKCDL 120
  121 SSRSVDFRTV SETAKGYGIP NVDTSAKTRM GVDEAFYTLV REIRKHRERH DNNKPQKKKK 180
  181 CQIM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 45.69897
Match: 1jahA
Description: H-RAS P21 PROTEIN MUTANT G12P, COMPLEXED WITH GUANOSINE-5'-[BETA,GAMMA-METHYLENE] TRIPHOSPHATE AND MAGNESIUM
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
GTPase activity 4.52394549632777 bayes_pls_golite062009
motor activity 4.04927796049806 bayes_pls_golite062009
microtubule motor activity 3.91769993918004 bayes_pls_golite062009
hydrolase activity 3.63069754092699 bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism 3.57926427233638 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 3.4837867129694 bayes_pls_golite062009
ion transmembrane transporter activity 3.35436118751376 bayes_pls_golite062009
transporter activity 3.10463051760206 bayes_pls_golite062009
cation transmembrane transporter activity 3.08390071341252 bayes_pls_golite062009
structural constituent of ribosome 3.070470376968 bayes_pls_golite062009
transmembrane transporter activity 2.95886887664984 bayes_pls_golite062009
nucleoside-triphosphatase activity 2.95079405147356 bayes_pls_golite062009
metal ion transmembrane transporter activity 2.88476360771975 bayes_pls_golite062009
pyrophosphatase activity 2.87427509025394 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 2.85499564954033 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 2.85178667290149 bayes_pls_golite062009
amine-transporting ATPase activity 2.69529191205818 bayes_pls_golite062009
organic acid transmembrane transporter activity 2.67957846350199 bayes_pls_golite062009
carboxylic acid transmembrane transporter activity 2.67815672695824 bayes_pls_golite062009
binding 2.64537357529343 bayes_pls_golite062009
primary active transmembrane transporter activity 2.61775212528604 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 2.61467977505707 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 2.61311581579476 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 2.57552435627908 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 2.57107347424517 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 2.57054427875021 bayes_pls_golite062009
microfilament motor activity 2.51786963027655 bayes_pls_golite062009
nucleic acid binding 2.51683451033161 bayes_pls_golite062009
active transmembrane transporter activity 2.50494515048649 bayes_pls_golite062009
ATPase activity, coupled 2.43862163407966 bayes_pls_golite062009
cytoskeletal protein binding 2.4101693596493 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 2.40292717311506 bayes_pls_golite062009
ATPase activity 2.39535714892224 bayes_pls_golite062009
G-protein coupled receptor activity 2.3505608190884 bayes_pls_golite062009
actin binding 2.2973522188675 bayes_pls_golite062009
amine transmembrane transporter activity 2.29486577878686 bayes_pls_golite062009
anion transmembrane-transporting ATPase activity 2.12727614888121 bayes_pls_golite062009
DNA binding 2.12258000781149 bayes_pls_golite062009
transcription regulator activity 2.09345198747025 bayes_pls_golite062009
structural molecule activity 2.08211451183607 bayes_pls_golite062009
tubulin binding 1.92557767696163 bayes_pls_golite062009
substrate-specific transporter activity 1.91091452720653 bayes_pls_golite062009
guanyl nucleotide binding 1.89320355239381 bayes_pls_golite062009
guanyl ribonucleotide binding 1.88721318481223 bayes_pls_golite062009
GTP binding 1.87900088157196 bayes_pls_golite062009
1.86855842486607 bayes_pls_golite062009
purine ribonucleotide binding 1.85943679361938 bayes_pls_golite062009
ribonucleotide binding 1.85937484083653 bayes_pls_golite062009
purine nucleotide binding 1.8521191028835 bayes_pls_golite062009
nucleotide binding 1.84603132945448 bayes_pls_golite062009
microtubule binding 1.84561785126784 bayes_pls_golite062009
kinase activity 1.80889641165674 bayes_pls_golite062009
protein transporter activity 1.71214667007262 bayes_pls_golite062009
helicase activity 1.70242731830224 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.60386625568858 bayes_pls_golite062009
amino acid transmembrane transporter activity 1.59627719545436 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 1.58971273330352 bayes_pls_golite062009
ATP binding 1.5859264197035 bayes_pls_golite062009
adenyl ribonucleotide binding 1.55520429131224 bayes_pls_golite062009
adenyl nucleotide binding 1.53158018507951 bayes_pls_golite062009
apolipoprotein receptor activity 1.52496551152043 bayes_pls_golite062009
syntaxin-13 binding 1.52496551152043 bayes_pls_golite062009
apolipoprotein A-I binding 1.52496551152043 bayes_pls_golite062009
apolipoprotein A-I receptor activity 1.52496551152043 bayes_pls_golite062009
signal recognition particle binding 1.46975774710831 bayes_pls_golite062009
antigen binding 1.43656260286121 bayes_pls_golite062009
cation channel activity 1.33585529285301 bayes_pls_golite062009
actin filament binding 1.28204719195916 bayes_pls_golite062009
transmembrane receptor activity 1.26314334516725 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions 1.23799860254751 bayes_pls_golite062009
protein binding 1.22129154759482 bayes_pls_golite062009
DNA-dependent ATPase activity 1.2155186842031 bayes_pls_golite062009
receptor activity 1.20313362488821 bayes_pls_golite062009
ATP-dependent helicase activity 1.19311444180077 bayes_pls_golite062009
purine NTP-dependent helicase activity 1.19311444180077 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.14475274823167 bayes_pls_golite062009
signal transducer activity 1.13474466330485 bayes_pls_golite062009
molecular transducer activity 1.13474466330485 bayes_pls_golite062009
protein kinase activity 1.12864835254143 bayes_pls_golite062009
nucleotide kinase activity 1.10251779925246 bayes_pls_golite062009
beta-catenin binding 1.03146778136145 bayes_pls_golite062009
voltage-gated cation channel activity 1.00384984515681 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
GMP binding 0.975301479415235 bayes_pls_golite062009
DNA-directed DNA polymerase activity 0.971476020912368 bayes_pls_golite062009
DNA polymerase activity 0.928091843881235 bayes_pls_golite062009
actin-dependent ATPase activity 0.92105578610354 bayes_pls_golite062009
peptide-transporting ATPase activity 0.911425383309011 bayes_pls_golite062009
voltage-gated ion channel activity 0.889208591820696 bayes_pls_golite062009
transcription factor activity 0.887108427603557 bayes_pls_golite062009
voltage-gated channel activity 0.871525745291603 bayes_pls_golite062009
ion channel activity 0.848261056209476 bayes_pls_golite062009
structural constituent of muscle 0.842950252373832 bayes_pls_golite062009
channel activity 0.806331380134838 bayes_pls_golite062009
passive transmembrane transporter activity 0.806331380134838 bayes_pls_golite062009
substrate-specific channel activity 0.799997700906738 bayes_pls_golite062009
structure-specific DNA binding 0.782430219754236 bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity 0.767424210804186 bayes_pls_golite062009
peptidase activity 0.742461247007442 bayes_pls_golite062009
transcription activator activity 0.739301862805678 bayes_pls_golite062009
peptide transporter activity 0.73541731084591 bayes_pls_golite062009
DNA helicase activity 0.72881469450553 bayes_pls_golite062009
ribonuclease activity 0.712344060953362 bayes_pls_golite062009
inorganic anion transmembrane transporter activity 0.69784475011795 bayes_pls_golite062009
potassium channel activity 0.694411056320469 bayes_pls_golite062009
protein-DNA loading ATPase activity 0.650964453464311 bayes_pls_golite062009
gated channel activity 0.650050847753837 bayes_pls_golite062009
steroid hormone receptor binding 0.647625526012423 bayes_pls_golite062009
calcium channel activity 0.636216614902039 bayes_pls_golite062009
double-stranded DNA binding 0.6071273686445 bayes_pls_golite062009
ATP-dependent DNA helicase activity 0.5886142102548 bayes_pls_golite062009
plus-end-directed microtubule motor activity 0.567883621045161 bayes_pls_golite062009
DNA clamp loader activity 0.543512707823441 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 0.543089473677103 bayes_pls_golite062009
ribonucleoprotein binding 0.53788302029845 bayes_pls_golite062009
DNA strand annealing activity 0.495691434532349 bayes_pls_golite062009
protein transmembrane transporter activity 0.46552249844591 bayes_pls_golite062009
branched-chain aliphatic amino acid transmembrane transporter activity 0.442220326523999 bayes_pls_golite062009
anion transmembrane transporter activity 0.43332053110728 bayes_pls_golite062009
signal sequence binding 0.42240724331108 bayes_pls_golite062009
phosphotransferase activity, phosphate group as acceptor 0.40217318916177 bayes_pls_golite062009
drug transmembrane transporter activity 0.38711726712063 bayes_pls_golite062009
hormone receptor binding 0.351501100511918 bayes_pls_golite062009
protein serine/threonine kinase activity 0.345873656782869 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.328170855722634 bayes_pls_golite062009
receptor binding 0.309955875731734 bayes_pls_golite062009
peptide binding 0.304703625340488 bayes_pls_golite062009
translation regulator activity 0.29096092258568 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.274994961137851 bayes_pls_golite062009
voltage-gated calcium channel activity 0.25979628626254 bayes_pls_golite062009
transition metal ion transmembrane transporter activity 0.248918847596573 bayes_pls_golite062009
nuclear hormone receptor binding 0.246160342138071 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.243902356228423 bayes_pls_golite062009
endopeptidase activity 0.237098238833913 bayes_pls_golite062009
RNA helicase activity 0.18426050934025 bayes_pls_golite062009
amino acid-transporting ATPase activity 0.147644650870465 bayes_pls_golite062009
RNA-dependent ATPase activity 0.14606996093053 bayes_pls_golite062009
ATP-dependent RNA helicase activity 0.13050483816765 bayes_pls_golite062009
nucleobase, nucleoside, nucleotide kinase activity 0.12351419478929 bayes_pls_golite062009
RNA binding 0.0693163519626152 bayes_pls_golite062009
cation-transporting ATPase activity 0.0536898657672154 bayes_pls_golite062009
G-protein-coupled receptor binding 0.0436504490626262 bayes_pls_golite062009
structural constituent of cytoskeleton 0.0111338193708552 bayes_pls_golite062009
P-P-bond-hydrolysis-driven protein transmembrane transporter activity 0.00571427458217011 bayes_pls_golite062009
macromolecule transmembrane transporter activity 0.00571427458217011 bayes_pls_golite062009
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