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View Structure Prediction Details

Protein: SEC4
Organism: Saccharomyces cerevisiae
Length: 215 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SEC4.

Description E-value Query
Range		 Subject
Range
ARA5_ARATH - Ras-related protein ARA-5 - Arabidopsis thaliana (Mouse-ear cress)
 6.0E-89 [10..215] [53..256]
rab-1 - RAS-related protein status:Confirmed UniProt:Q9UAQ6 protein_id:AAC69218.1
 1.0E-88 [11..215] [2..205]
gi|1370166 - gi|1370166|emb|CAA98160.1| RAB1C [Lotus japonicus]
 2.0E-88 [14..215] [2..200]
RIC2_ORYSA - Ras-related protein RIC2 - Oryza sativa (Rice)
RIC2_ORYSJ - Ras-related protein RIC2 OS=Oryza sativa subsp. japonica GN=RIC2 PE=2 SV=2
gi|125555691 - gi|125555691|gb|EAZ01297.1| hypothetical protein OsI_23327 [Oryza sativa Indica Group]
 5.0E-88 [7..215] [1..215]
gi|1616614 - gi|1616614|emb|CAA69701.1| small GTP-binding protein [Nicotiana plumbaginifolia]
 7.0E-88 [14..215] [2..201]
gi|4586580 - gi|4586580|dbj|BAA76422.1| rab-type small GTP-binding protein [Cicer arietinum]
 1.0E-87 [14..215] [2..200]

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Predicted Domain #1
Region A:
Residues: [1-215] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGLRTVSAS SGNGKSYDSI MKILLIGDSG VGKSCLLVRF VEDKFNPSFI TTIGIDFKIK  60
   61 TVDINGKKVK LQLWDTAGQE RFRTITTAYY RGAMGIILVY DVTDERTFTN IKQWFKTVNE 120
  121 HANDEAQLLL VGNKSDMETR VVTADQGEAL AKELGIPFIE SSAKNDDNVN EIFFTLAKLI 180
  181 QEKIDSNKLV GVGNGKEGNI SINSGSGNSS KSNCC

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 968.274545
Match: 1g17A_
Description: Rab-related protein Sec4
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
GTPase activity 4.52394549632777 bayes_pls_golite062009
microtubule motor activity 4.51968578934603 bayes_pls_golite062009
motor activity 4.04927796049806 bayes_pls_golite062009
hydrolase activity 3.63069754092699 bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism 3.57926427233638 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 3.4837867129694 bayes_pls_golite062009
ion transmembrane transporter activity 3.35436118751376 bayes_pls_golite062009
actin binding 3.33639699088484 bayes_pls_golite062009
microfilament motor activity 3.17800963620802 bayes_pls_golite062009
transporter activity 3.10463051760206 bayes_pls_golite062009
cation transmembrane transporter activity 3.08390071341252 bayes_pls_golite062009
structural constituent of ribosome 3.070470376968 bayes_pls_golite062009
transmembrane transporter activity 2.95886887664984 bayes_pls_golite062009
nucleoside-triphosphatase activity 2.95079405147356 bayes_pls_golite062009
pyrophosphatase activity 2.87427509025394 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 2.85499564954033 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 2.85178667290149 bayes_pls_golite062009
amine-transporting ATPase activity 2.69529191205818 bayes_pls_golite062009
organic acid transmembrane transporter activity 2.67957846350199 bayes_pls_golite062009
carboxylic acid transmembrane transporter activity 2.67815672695824 bayes_pls_golite062009
tubulin binding 2.67743463093593 bayes_pls_golite062009
binding 2.64537357529343 bayes_pls_golite062009
primary active transmembrane transporter activity 2.61775212528604 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 2.61467977505707 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 2.61311581579476 bayes_pls_golite062009
microtubule binding 2.59155206524122 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 2.57552435627908 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 2.57107347424517 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 2.57054427875021 bayes_pls_golite062009
nucleic acid binding 2.51683451033161 bayes_pls_golite062009
active transmembrane transporter activity 2.50494515048649 bayes_pls_golite062009
ATPase activity, coupled 2.43862163407966 bayes_pls_golite062009
cytoskeletal protein binding 2.4101693596493 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 2.40292717311506 bayes_pls_golite062009
ATPase activity 2.39535714892224 bayes_pls_golite062009
amine transmembrane transporter activity 2.29486577878686 bayes_pls_golite062009
metal ion transmembrane transporter activity 2.26365379756656 bayes_pls_golite062009
actin filament binding 2.24723363507804 bayes_pls_golite062009
anion transmembrane-transporting ATPase activity 2.12727614888121 bayes_pls_golite062009
DNA binding 2.12258000781149 bayes_pls_golite062009
transcription regulator activity 2.09345198747025 bayes_pls_golite062009
structural molecule activity 2.08211451183607 bayes_pls_golite062009
proton-transporting ATPase activity, rotational mechanism 1.95782378818812 bayes_pls_golite062009
substrate-specific transporter activity 1.91091452720653 bayes_pls_golite062009
guanyl nucleotide binding 1.89320355239381 bayes_pls_golite062009
guanyl ribonucleotide binding 1.88721318481223 bayes_pls_golite062009
GTP binding 1.87900088157196 bayes_pls_golite062009
1.86855842486607 bayes_pls_golite062009
purine ribonucleotide binding 1.85943679361938 bayes_pls_golite062009
ribonucleotide binding 1.85937484083653 bayes_pls_golite062009
purine nucleotide binding 1.8521191028835 bayes_pls_golite062009
nucleotide binding 1.84603132945448 bayes_pls_golite062009
kinase activity 1.80889641165674 bayes_pls_golite062009
structural constituent of muscle 1.75982319871463 bayes_pls_golite062009
protein transporter activity 1.71214667007262 bayes_pls_golite062009
helicase activity 1.70242731830224 bayes_pls_golite062009
G-protein coupled receptor activity 1.63949223587737 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.60386625568858 bayes_pls_golite062009
amino acid transmembrane transporter activity 1.59627719545436 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 1.58971273330352 bayes_pls_golite062009
actin-dependent ATPase activity 1.58897222423517 bayes_pls_golite062009
ATP binding 1.5859264197035 bayes_pls_golite062009
adenyl ribonucleotide binding 1.55520429131224 bayes_pls_golite062009
adenyl nucleotide binding 1.53158018507951 bayes_pls_golite062009
plus-end-directed microtubule motor activity 1.38366133153678 bayes_pls_golite062009
apolipoprotein receptor activity 1.31055516357904 bayes_pls_golite062009
syntaxin-13 binding 1.31055516357904 bayes_pls_golite062009
apolipoprotein A-I binding 1.31055516357904 bayes_pls_golite062009
apolipoprotein A-I receptor activity 1.31055516357904 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions 1.23799860254751 bayes_pls_golite062009
protein binding 1.22129154759482 bayes_pls_golite062009
DNA-dependent ATPase activity 1.2155186842031 bayes_pls_golite062009
ATP-dependent helicase activity 1.19311444180077 bayes_pls_golite062009
purine NTP-dependent helicase activity 1.19311444180077 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.14475274823167 bayes_pls_golite062009
peptidase activity 1.12876670227791 bayes_pls_golite062009
protein kinase activity 1.12864835254143 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
cation channel activity 0.997064416395892 bayes_pls_golite062009
GMP binding 0.975301479415235 bayes_pls_golite062009
DNA-directed DNA polymerase activity 0.971476020912368 bayes_pls_golite062009
DNA polymerase activity 0.928091843881235 bayes_pls_golite062009
peptide-transporting ATPase activity 0.911425383309011 bayes_pls_golite062009
transcription activator activity 0.889929694023098 bayes_pls_golite062009
transcription factor activity 0.887108427603557 bayes_pls_golite062009
protein methyltransferase activity 0.876296121718575 bayes_pls_golite062009
transferase activity 0.871779313294914 bayes_pls_golite062009
transferase activity, transferring glycosyl groups 0.813093882989183 bayes_pls_golite062009
structure-specific DNA binding 0.782430219754236 bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity 0.767424210804186 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 0.765442336337003 bayes_pls_golite062009
peptide transporter activity 0.73541731084591 bayes_pls_golite062009
DNA helicase activity 0.72881469450553 bayes_pls_golite062009
ribonuclease activity 0.712344060953362 bayes_pls_golite062009
inorganic anion transmembrane transporter activity 0.69784475011795 bayes_pls_golite062009
voltage-gated cation channel activity 0.688632087597536 bayes_pls_golite062009
signal transducer activity 0.683309012097319 bayes_pls_golite062009
molecular transducer activity 0.683309012097319 bayes_pls_golite062009
transmembrane receptor activity 0.661834961742057 bayes_pls_golite062009
protein-DNA loading ATPase activity 0.650964453464311 bayes_pls_golite062009
steroid hormone receptor binding 0.647625526012423 bayes_pls_golite062009
calcium channel activity 0.636216614902039 bayes_pls_golite062009
receptor activity 0.633514002718998 bayes_pls_golite062009
histone methyltransferase activity 0.63002958837536 bayes_pls_golite062009
cell surface binding 0.618263399939881 bayes_pls_golite062009
double-stranded DNA binding 0.6071273686445 bayes_pls_golite062009
ATP-dependent DNA helicase activity 0.5886142102548 bayes_pls_golite062009
nucleotide kinase activity 0.56979593127581 bayes_pls_golite062009
beta-catenin binding 0.567325521781475 bayes_pls_golite062009
voltage-gated channel activity 0.562664200036023 bayes_pls_golite062009
voltage-gated ion channel activity 0.559798751382976 bayes_pls_golite062009
sequence-specific DNA binding 0.543891899378373 bayes_pls_golite062009
DNA clamp loader activity 0.543512707823441 bayes_pls_golite062009
DNA strand annealing activity 0.495691434532349 bayes_pls_golite062009
protein transmembrane transporter activity 0.46552249844591 bayes_pls_golite062009
branched-chain aliphatic amino acid transmembrane transporter activity 0.442220326523999 bayes_pls_golite062009
anion transmembrane transporter activity 0.43332053110728 bayes_pls_golite062009
signal sequence binding 0.42240724331108 bayes_pls_golite062009
drug transmembrane transporter activity 0.38711726712063 bayes_pls_golite062009
hormone receptor binding 0.351501100511918 bayes_pls_golite062009
protein serine/threonine kinase activity 0.345873656782869 bayes_pls_golite062009
potassium channel activity 0.329290830676079 bayes_pls_golite062009
gated channel activity 0.299411774392227 bayes_pls_golite062009
translation regulator activity 0.29096092258568 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.274994961137851 bayes_pls_golite062009
myosin binding 0.274885859454447 bayes_pls_golite062009
transition metal ion transmembrane transporter activity 0.248918847596573 bayes_pls_golite062009
nuclear hormone receptor binding 0.246160342138071 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.243902356228423 bayes_pls_golite062009
signal recognition particle binding 0.20866768220789 bayes_pls_golite062009
RNA helicase activity 0.18426050934025 bayes_pls_golite062009
ion channel activity 0.154779598791225 bayes_pls_golite062009
amino acid-transporting ATPase activity 0.147644650870465 bayes_pls_golite062009
RNA-dependent ATPase activity 0.14606996093053 bayes_pls_golite062009
channel activity 0.134817721656507 bayes_pls_golite062009
passive transmembrane transporter activity 0.134817721656507 bayes_pls_golite062009
ATP-dependent RNA helicase activity 0.13050483816765 bayes_pls_golite062009
substrate-specific channel activity 0.126911677161968 bayes_pls_golite062009
nucleobase, nucleoside, nucleotide kinase activity 0.12351419478929 bayes_pls_golite062009
minus-end directed microfilament motor activity 0.103268955687259 bayes_pls_golite062009
GBD domain binding 0.0922383758186687 bayes_pls_golite062009
voltage-gated calcium channel activity 0.0789800146503108 bayes_pls_golite062009
RNA binding 0.0693163519626152 bayes_pls_golite062009
cation-transporting ATPase activity 0.0536898657672154 bayes_pls_golite062009
structural constituent of cytoskeleton 0.0111338193708552 bayes_pls_golite062009
P-P-bond-hydrolysis-driven protein transmembrane transporter activity 0.00571427458217011 bayes_pls_golite062009
macromolecule transmembrane transporter activity 0.00571427458217011 bayes_pls_golite062009
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