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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Hrr25. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 17 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
CDC25
  • cytoplasm
  • plasma membrane
  • traversing start control point of mitotic cell cycle
  • Ras protein signal transduction
  • replicative cell aging
  • Ras guanyl-nucleotide exchange factor activity
  • CKA2
  • protein kinase CK2 complex
  • G2/M transition of mitotic cell cycle
  • G1/S transition of mitotic cell cycle
  • flocculation via cell wall protein-carbohydrate interaction
  • protein amino acid phosphorylation
  • response to DNA damage stimulus
  • regulation of transcription from RNA polymerase III promoter
  • regulation of transcription from RNA polymerase I promoter
  • cellular ion homeostasis
  • protein kinase CK2 activity
  • DCP2
  • nucleus
  • cytoplasm
  • cytoplasmic mRNA processing body
  • deadenylation-independent decapping of nuclear-transcribed mRNA
  • deadenylation-dependent decapping of nuclear-transcribed mRNA
  • mRNA catabolic process
  • mRNA binding
  • m7G(5')pppN diphosphatase activity
  • hydrolase activity
  • EDC3
  • cytoplasmic mRNA processing body
  • deadenylation-independent decapping of nuclear-transcribed mRNA
  • molecular_function
  • EDE1
  • cellular bud tip
  • cellular bud neck
  • actin cortical patch
  • endocytosis
  • ubiquitin binding
  • ENP1
  • nucleus
  • nuclear outer membrane
  • nucleolus
  • preribosome, small subunit precursor
  • ribosome biogenesis
  • rRNA processing
  • snoRNA binding
  • FPR3
  • nucleolus
  • meiotic recombination checkpoint
  • peptidyl-prolyl cis-trans isomerase activity
  • GLC7
  • protein phosphatase type 1 complex
  • mRNA cleavage and polyadenylation specificity factor complex
  • cellular bud neck
  • spindle pole body
  • nuclear outer membrane
  • nucleolus
  • mating projection base
  • mitotic cell cycle spindle assembly checkpoint
  • cell morphogenesis during vegetative growth
  • protein amino acid dephosphorylation
  • chromosome segregation
  • cell budding
  • cellular ion homeostasis
  • meiosis
  • regulation of carbohydrate metabolic process
  • ascospore formation
  • response to heat
  • termination of RNA polymerase II transcription, poly(A)-coupled
  • glycogen metabolic process
  • termination of RNA polymerase II transcription, poly(A)-independent
  • histone dephosphorylation
  • protein serine/threonine phosphatase activity
  • phosphoprotein phosphatase activity
  • RNA binding
  • metal ion binding
  • hydrolase activity
  • HRR25
  • nucleus
  • plasma membrane
  • DNA repair
  • nuclear division
  • ribosomal small subunit biogenesis
  • chromosome segregation
  • mitosis
  • meiosis
  • casein kinase activity
  • MDS3
  • cytoplasm
  • mitochondrion
  • negative regulation of sporulation resulting in formation of a cellular spore
  • molecular_function
  • RPM2
  • nucleus
  • mitochondrial ribonuclease P complex
  • mitochondrion
  • cytoplasmic mRNA processing body
  • RNA processing
  • mRNA processing
  • positive regulation of transcription from RNA polymerase II promoter
  • tRNA 5'-leader removal
  • mitochondrion organization
  • translation
  • ribonuclease P activity
  • transcription activator activity
  • SEC23
  • cytoplasm
  • COPII vesicle coat
  • ER to Golgi vesicle-mediated transport
  • autophagy
  • ER-associated protein catabolic process
  • GTPase activator activity
  • SFB3
  • endoplasmic reticulum
  • peripheral to membrane of membrane fraction
  • COPII vesicle coat
  • ER to Golgi vesicle-mediated transport
  • molecular_function
  • SGM1
  • Golgi apparatus
  • COPI-coated vesicle
  • biological_process
  • molecular_function
  • SIT4
  • nucleus
  • cytoplasm
  • DNA repair
  • G1/S transition of mitotic cell cycle
  • cellular cell wall organization
  • telomere maintenance
  • intracellular protein kinase cascade
  • protein amino acid phosphorylation
  • replicative cell aging
  • actin cytoskeleton organization
  • protein serine/threonine phosphatase activity
  • TGL1
  • lipid particle
  • integral to membrane
  • lipid metabolic process
  • sterol metabolic process
  • sterol esterase activity
  • lipase activity
  • TSR1
  • cytoplasm
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • ribonucleoprotein binding
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    cytoplasmic mRNA processing body 7.3081E-6 17 15 3 6292
    COPII vesicle coat 1.9058E-4 17 8 2 6292
    ER to Golgi transport vesicle membrane 1.9058E-4 17 8 2 6292
    transport vesicle membrane 7.0676E-4 17 15 2 6292
    coated vesicle 1.3172E-3 17 83 3 6292
    nucleolus 2.074E-3 17 211 4 6292
    mitochondrial ribonuclease P complex 2.7018E-3 17 1 1 6292
    membrane-bounded vesicle 2.7334E-3 17 107 3 6292
    cytoplasmic vesicle 2.7334E-3 17 107 3 6292
    cytoplasmic membrane-bounded vesicle 2.7334E-3 17 107 3 6292
    vesicle 2.9573E-3 17 110 3 6292
    ER to Golgi transport vesicle 3.0514E-3 17 31 2 6292
    vesicle coat 3.6639E-3 17 34 2 6292
    coated vesicle membrane 3.8798E-3 17 35 2 6292
    cytoplasmic vesicle membrane 3.8798E-3 17 35 2 6292
    vesicle membrane 3.8798E-3 17 35 2 6292
    membrane coat 4.5622E-3 17 38 2 6292
    coated membrane 4.5622E-3 17 38 2 6292
    cytoplasmic vesicle part 4.8012E-3 17 39 2 6292
    transport vesicle 6.3538E-3 17 45 2 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nuclear-transcribed mRNA catabolic process, deadenylation-independent decay 6.8716E-6 17 2 2 6292
    deadenylation-independent decapping of nuclear-transcribed mRNA 6.8716E-6 17 2 2 6292
    cell cycle phase 3.0801E-4 17 376 6 6292
    mitotic cell cycle 4.3561E-4 17 255 5 6292
    cell cycle process 1.2732E-3 17 490 6 6292
    cell cycle 1.826E-3 17 525 6 6292
    interphase of mitotic cell cycle 2.0647E-3 17 97 3 6292
    interphase 2.0647E-3 17 97 3 6292
    signal transduction 2.1843E-3 17 214 4 6292
    signal transmission 2.2987E-3 17 217 4 6292
    signaling process 2.2987E-3 17 217 4 6292
    tRNA 5'-leader removal 2.7018E-3 17 1 1 6292
    regulation of cellular process 3.1119E-3 17 796 7 6292
    negative regulation of cell cycle process 3.2496E-3 17 32 2 6292
    regulation of biological process 3.8007E-3 17 824 7 6292
    signaling 3.9576E-3 17 252 4 6292
    nuclear-transcribed mRNA catabolic process 4.5622E-3 17 38 2 6292
    replicative cell aging 4.5622E-3 17 38 2 6292
    regulation of cell cycle 4.8439E-3 17 131 3 6292
    negative regulation of developmental process 5.3968E-3 17 2 1 6292
    regulation of sporulation 5.3968E-3 17 2 1 6292
    negative regulation of sporulation 5.3968E-3 17 2 1 6292
    meiotic prophase I 5.3968E-3 17 2 1 6292
    regulation of sporulation resulting in formation of a cellular spore 5.3968E-3 17 2 1 6292
    negative regulation of sporulation resulting in formation of a cellular spore 5.3968E-3 17 2 1 6292
    histone dephosphorylation 5.3968E-3 17 2 1 6292
    meiotic cell cycle checkpoint 5.3968E-3 17 2 1 6292
    prophase 5.3968E-3 17 2 1 6292
    regulation of cell differentiation 5.3968E-3 17 2 1 6292
    negative regulation of cell differentiation 5.3968E-3 17 2 1 6292
    meiotic recombination checkpoint 5.3968E-3 17 2 1 6292
    nucleic acid metabolic process 5.909E-3 17 1415 9 6292
    cell aging 7.4998E-3 17 49 2 6292
    G1/S transition of mitotic cell cycle 7.8E-3 17 50 2 6292
    aging 8.1055E-3 17 51 2 6292
    meiosis 8.4428E-3 17 160 3 6292
    M phase of meiotic cell cycle 8.4428E-3 17 160 3 6292
    RNA metabolic process 8.6957E-3 17 954 7 6292
    meiotic cell cycle 9.0355E-3 17 164 3 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    protein serine/threonine phosphatase activity 2.1497E-3 17 26 2 6292
    casein kinase activity 2.7018E-3 17 1 1 6292
    protein kinase CK2 activity 5.3968E-3 17 2 1 6292
    phosphoprotein phosphatase activity 5.8138E-3 17 43 2 6292
    sterol esterase activity 8.0849E-3 17 3 1 6292

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