YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Pph22. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 13 proteins

Complex Member Proteins

Protein

 GO Cellular Component GO Biological Process GO Molecular Function
CDC55
  • nucleus
  • cellular bud tip
  • cellular bud neck
  • protein phosphatase type 2A complex
    		•
  • mitotic cell cycle spindle assembly checkpoint
  • negative regulation of exit from mitosis
  • protein amino acid dephosphorylation
  • pseudohyphal growth
  • actin filament organization
  • budding cell bud growth
  • translation
    		•
  • protein serine/threonine phosphatase activity
  • protein phosphatase type 2A regulator activity
    		•
    GPG1
  • cellular_component
    		•
  • signal transduction
    		•
  • signal transducer activity
    		•
    HTA2
  • nuclear nucleosome
    		•
  • DNA repair
  • chromatin assembly or disassembly
    		•
  • DNA binding
    		•
    MKT1
  • polysome
  • cytoplasm
    		•
  • interspecies interaction between organisms
  • positive regulation of translation
    		•
  • nuclease activity
    		•
    PPE1
  • soluble fraction
    		•
  • sinus venosus formation
  • protein modification process
  • telomere maintenance
    		•
  • carboxylesterase activity
  • hydrolase activity
    		•
    PPH22
  • condensed nuclear chromosome, centromeric region
  • protein phosphatase type 2A complex
    		•
  • mitotic cell cycle spindle assembly checkpoint
  • G1/S transition of mitotic cell cycle
  • protein amino acid dephosphorylation
  • actin filament organization
  • budding cell bud growth
  • translation
    		•
  • protein serine/threonine phosphatase activity
  • phosphoprotein phosphatase activity
  • metal ion binding
  • hydrolase activity
    		•
    RPA135
  • DNA-directed RNA polymerase I complex
    		•
  • transcription from RNA polymerase I promoter
  • ribosome biogenesis
    		•
  • DNA-directed RNA polymerase activity
    		•
    RPB11
  • DNA-directed RNA polymerase II, core complex
    		•
  • transcription from RNA polymerase II promoter
    		•
  • DNA-directed RNA polymerase activity
    		•
    RTS1
  • nucleus
  • condensed nuclear chromosome, centromeric region
  • cytoplasm
  • cellular bud neck
  • spindle pole body
  • protein phosphatase type 2A complex
    		•
  • protein amino acid dephosphorylation
  • meiotic sister chromatid cohesion, centromeric
  • translation
    		•
  • protein serine/threonine phosphatase activity
  • protein phosphatase type 2A regulator activity
    		•
    RTS3
  • nucleus
  • cytoplasm
  • protein phosphatase type 2A complex
    		•
  • protein amino acid dephosphorylation
    		•
  • molecular_function
    		•
    RVB1
  • nucleus
  • Swr1 complex
  • Ino80 complex
  • chromatin remodeling complex
    		•
  • chromatin remodeling
  • regulation of transcription from RNA polymerase II promoter
    		•
  • ATPase activity
  • ATP-dependent 5'-3' DNA helicase activity
    		•
    TAP42
  • cellular_component
    		•
  • signal transduction
    		•
  • protein binding
    		•
    TPD3
  • nucleus
  • cellular bud tip
  • cytoplasm
  • cellular bud neck
  • spindle pole body
  • mating projection tip
  • protein phosphatase type 2A complex
    		•
  • mitotic cell cycle spindle assembly checkpoint
  • protein amino acid dephosphorylation
  • actin filament organization
  • budding cell bud growth
  • translation
    		•

    Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    protein phosphatase type 2A complex 9.4015E-14 13 6 5 6292
    protein serine/threonine phosphatase complex 9.5835E-11 13 17 5 6292
    macromolecular complex 1.7639E-4 13 1635 10 6292
    nuclear chromosome part 4.6506E-4 13 190 4 6292
    protein complex 6.0345E-4 13 1137 8 6292
    nuclear chromosome 9.2751E-4 13 228 4 6292
    chromosomal part 1.0726E-3 13 237 4 6292
    DNA-directed RNA polymerase complex 1.7717E-3 13 31 2 6292
    RNA polymerase complex 1.7717E-3 13 31 2 6292
    nuclear DNA-directed RNA polymerase complex 1.7717E-3 13 31 2 6292
    chromosome 1.8414E-3 13 274 4 6292
    cellular bud neck 2.0717E-3 13 129 3 6292
    cellular bud 4.2448E-3 13 166 3 6292
    site of polarized growth 4.3905E-3 13 168 3 6292
    condensed chromosome, centromeric region 5.5019E-3 13 55 2 6292
    condensed nuclear chromosome, centromeric region 5.5019E-3 13 55 2 6292
    cellular bud tip 5.8994E-3 13 57 2 6292
    microtubule organizing center 7.1687E-3 13 63 2 6292
    spindle pole body 7.1687E-3 13 63 2 6292
    nucleus 7.1693E-3 13 2041 9 6292
    chromosome, centromeric region 8.078E-3 13 67 2 6292
    non-membrane-bounded organelle 8.0908E-3 13 959 6 6292
    intracellular non-membrane-bounded organelle 8.0908E-3 13 959 6 6292
    spindle pole 8.3131E-3 13 68 2 6292
    nuclear chromatin 9.5347E-3 13 73 2 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    protein amino acid dephosphorylation 1.5044E-9 13 28 5 6292
    dephosphorylation 9.9445E-9 13 40 5 6292
    mitotic cell cycle spindle assembly checkpoint 8.9718E-6 13 21 3 6292
    negative regulation of nuclear division 8.9718E-6 13 21 3 6292
    negative regulation of mitosis 8.9718E-6 13 21 3 6292
    negative regulation of mitotic metaphase/anaphase transition 8.9718E-6 13 21 3 6292
    spindle assembly checkpoint 8.9718E-6 13 21 3 6292
    negative regulation of cell cycle 1.0376E-5 13 22 3 6292
    spindle checkpoint 1.5441E-5 13 25 3 6292
    regulation of mitotic metaphase/anaphase transition 1.5441E-5 13 25 3 6292
    mitotic cell cycle spindle checkpoint 1.5441E-5 13 25 3 6292
    mitotic cell cycle checkpoint 2.1915E-5 13 28 3 6292
    negative regulation of cellular component organization 2.4414E-5 13 29 3 6292
    regulation of nuclear division 2.4414E-5 13 29 3 6292
    negative regulation of organelle organization 2.4414E-5 13 29 3 6292
    regulation of mitosis 2.4414E-5 13 29 3 6292
    negative regulation of cell cycle process 3.3022E-5 13 32 3 6292
    budding cell bud growth 3.9744E-5 13 34 3 6292
    signal transduction 4.4729E-5 13 214 5 6292
    signal transmission 4.7829E-5 13 217 5 6292
    signaling process 4.7829E-5 13 217 5 6292
    mitotic metaphase/anaphase transition 5.1422E-5 13 37 3 6292
    phosphorus metabolic process 6.194E-5 13 229 5 6292
    phosphate metabolic process 6.194E-5 13 229 5 6292
    signaling 9.7878E-5 13 252 5 6292
    regulation of organelle organization 1.4366E-4 13 52 3 6292
    cell cycle checkpoint 1.9914E-4 13 58 3 6292
    protein modification process 2.5567E-4 13 499 6 6292
    actin filament organization 3.1959E-4 13 68 3 6292
    regulation of mitotic cell cycle 3.6318E-4 13 71 3 6292
    regulation of cellular component organization 4.2702E-4 13 75 3 6292
    regulation of cellular process 4.3416E-4 13 796 7 6292
    cellular macromolecule metabolic process 4.9766E-4 13 2285 11 6292
    post-translational protein modification 5.0375E-4 13 357 5 6292
    macromolecule modification 5.2532E-4 13 569 6 6292
    regulation of cell cycle process 5.3569E-4 13 81 3 6292
    regulation of biological process 5.3931E-4 13 824 7 6292
    translation 6.4023E-4 13 376 5 6292
    macromolecule metabolic process 6.5617E-4 13 2349 11 6292
    cell budding 7.297E-4 13 90 3 6292
    asexual reproduction 7.297E-4 13 90 3 6292
    cellular macromolecule biosynthetic process 8.1749E-4 13 1187 8 6292
    macromolecule biosynthetic process 8.2722E-4 13 1189 8 6292
    biological regulation 9.5169E-4 13 1213 8 6292
    mitosis 1.1123E-3 13 104 3 6292
    nuclear division 1.1755E-3 13 106 3 6292
    gene expression 1.4068E-3 13 1283 8 6292
    organelle fission 1.4147E-3 13 113 3 6292
    actin cytoskeleton organization 1.4147E-3 13 113 3 6292
    actin filament-based process 1.5643E-3 13 117 3 6292
    M phase of mitotic cell cycle 2.0259E-3 13 128 3 6292
    meiotic sister chromatid cohesion, centromeric 2.0661E-3 13 1 1 6292
    regulation of cell cycle 2.1651E-3 13 131 3 6292
    M phase 2.3879E-3 13 294 4 6292
    cellular protein metabolic process 2.7355E-3 13 1074 7 6292
    growth 2.8937E-3 13 145 3 6292
    cell division 2.8937E-3 13 145 3 6292
    organelle organization 3.6442E-3 13 1127 7 6292
    protein metabolic process 3.8198E-3 13 1136 7 6292
    meiotic sister chromatid cohesion 4.1283E-3 13 2 1 6292
    interspecies interaction between organisms 4.1283E-3 13 2 1 6292
    primary metabolic process 5.1003E-3 13 2896 11 6292
    cellular biosynthetic process 5.4621E-3 13 1567 8 6292
    cell cycle phase 5.8264E-3 13 376 4 6292
    cardiac chamber development 6.1865E-3 13 3 1 6292
    cardiac chamber morphogenesis 6.1865E-3 13 3 1 6292
    cardiac chamber formation 6.1865E-3 13 3 1 6292
    heart development 6.1865E-3 13 3 1 6292
    heart morphogenesis 6.1865E-3 13 3 1 6292
    organ morphogenesis 6.1865E-3 13 3 1 6292
    sinus venosus development 6.1865E-3 13 3 1 6292
    sinus venosus morphogenesis 6.1865E-3 13 3 1 6292
    sinus venosus formation 6.1865E-3 13 3 1 6292
    biosynthetic process 6.3198E-3 13 1602 8 6292
    cellular metabolic process 7.9165E-3 13 3033 11 6292
    positive regulation of translation 8.2408E-3 13 4 1 6292
    negative regulation of exit from mitosis 8.2408E-3 13 4 1 6292
    reproduction of a single-celled organism 8.9563E-3 13 217 3 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    protein serine/threonine phosphatase activity 1.7434E-5 13 26 3 6292
    protein phosphatase type 2A regulator activity 2.3591E-5 13 4 2 6292
    phosphoprotein phosphatase activity 8.1089E-5 13 43 3 6292
    hydrolase activity, acting on ester bonds 4.0711E-4 13 341 5 6292
    phosphatase activity 6.6074E-4 13 87 3 6292
    protein phosphatase regulator activity 9.7297E-4 13 23 2 6292
    phosphatase regulator activity 9.7297E-4 13 23 2 6292
    phosphoric ester hydrolase activity 1.0513E-3 13 102 3 6292
    RNA polymerase activity 2.13E-3 13 34 2 6292
    DNA-directed RNA polymerase activity 2.13E-3 13 34 2 6292
    hydrolase activity 6.2534E-3 13 911 6 6292
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle