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A signal transduction-based surveillance mechanism that acts during a mitotic cell cycle to ensure accurate chromosome segregation by preventing entry into mitosis in the presence of damaged DNA. A signal transduction-based surveillance mechanism that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage. Any cell cycle checkpoint that delays or arrests cell cycle progression until cells have reached a critical size. Any cell cycle checkpoint that blocks entry into S phase. A cell cycle checkpoint which halts replication in response to nucleotide depletion. The process whereby a signal is released and/or conveyed from one location to another. The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. Any process that modulates the rate or extent of progress through the mitotic cell cycle. Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. Any process that modulates the rate or extent of progression through the cell cycle. The cell cycle regulatory process by which progression through the cycle can be halted until conditions are suitable for the cell to proceed to the next stage. A cell cycle checkpoint observed when aspects of polarity control are defective, which maintains coordination between the process of cellular morphogenesis and the nuclear events of the cell cycle. For example, in budding yeast cell-cycle delay or arrest is induced when aspects of bud formation are defective. A cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle. Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent. A signal transduction based surveillance mechanism that acts during a mitotic cell cycle and prevents the initiation of mitosis until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: mitotic cell cycle checkpoint
Acc: GO:0007093
Aspect: Biological Process
Desc: A signal transduction-based surveillance mechanism that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage.
Synonyms:
  • mitotic checkpoint
  • regulation of mitotic cell cycle by cell cycle checkpoint
Proteins in PDR annotated with:
   This term: 29 [Search]
   Term or descendants: 184 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0007093 - mitotic cell cycle checkpoint (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle