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A signal transduction based surveillance mechanism that ensures the fidelity of cell division by preventing the premature advance of cells from metaphase to anaphase prior to the successful attachment of kinetochores to spindle microtubules (spindle assembly). Any process that stops, prevents or reduces the rate or extent of mitosis. Mitosis is the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother. Any process that modulates the frequency, rate or extent of mitosis. A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell. Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Any process that decreases the rate frequency or extent of anaphase-promoting complex activity regulating the mitotic cell cycle. Any process that stops, prevents or reduces the frequency, rate or extent of the mitotic metaphase to anaphase transition. Any process that modulates the frequency, rate or extent of the onset of anaphase (chromosome movement) in the mitotic cell cycle. A cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle. The cell cycle process whereby a cell progresses from metaphase to anaphase during mitosis, triggered by the destruction of mitotic cyclins. Any process that stops, prevents or reduces the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of mitotic metaphase/anaphase transition
Acc: GO:0045841
Aspect: Biological Process
Desc: Any process that stops, prevents or reduces the frequency, rate or extent of the mitotic metaphase to anaphase transition.
Synonyms:
  • down regulation of mitotic metaphase/anaphase transition
  • downregulation of mitotic metaphase/anaphase transition
  • inhibition of mitotic metaphase/anaphase transition
  • down-regulation of mitotic metaphase/anaphase transition
Proteins in PDR annotated with:
   This term: 4 [Search]
   Term or descendants: 95 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0045841 - negative regulation of mitotic metaphase/anaphase transition (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle