YRC Public Data Repository - Protein Complex GO Analysis

Complex Overview

From Publication:	Gavin A.C. et al. (2002) Abstract Functional organization of the yeast proteome by systematic analysis of protein complexes. Nature. 2002 Jan 10;415(6868):141-7.
Notes:	From the published set of protein complexes.
Complex Size:	36 proteins

Complex Member Proteins

Protein	GO Cellular Component	GO Biological Process	GO Molecular Function
BLM10	nucleus proteasome core complex proteasome complex	protein catabolic process proteasome assembly	proteasome activator activity
CDC6	pre-replicative complex	pre-replicative complex assembly	ATPase activity DNA clamp loader activity protein binding
ECM29	nucleus cytoplasm proteasome complex	protein catabolic process	protein binding
MLH2	nucleus	DNA repair	molecular_function
PGK1	cytoplasm mitochondrion	gluconeogenesis glycolysis	phosphoglycerate kinase activity
PRE1	nucleus proteasome core complex, beta-subunit complex	ascospore formation response to stress ubiquitin-dependent protein catabolic process	endopeptidase activity
PRE10	proteasome core complex, alpha-subunit complex	ubiquitin-dependent protein catabolic process	endopeptidase activity
PRE2	proteasome core complex, beta-subunit complex	ubiquitin-dependent protein catabolic process	endopeptidase activity
PRE3	proteasome core complex, beta-subunit complex	ascospore formation response to stress ubiquitin-dependent protein catabolic process	endopeptidase activity
PRE4	proteasome core complex, beta-subunit complex	ubiquitin-dependent protein catabolic process	endopeptidase activity
PRE5	proteasome core complex, alpha-subunit complex	ubiquitin-dependent protein catabolic process	endopeptidase activity
PRE6	mitochondrion proteasome core complex, alpha-subunit complex cytosol	ubiquitin-dependent protein catabolic process	endopeptidase activity
PRE7	proteasome core complex, beta-subunit complex	ubiquitin-dependent protein catabolic process	endopeptidase activity
PRE8	proteasome core complex, alpha-subunit complex	ubiquitin-dependent protein catabolic process	endopeptidase activity
PRE9	proteasome core complex, alpha-subunit complex	filamentous growth ubiquitin-dependent protein catabolic process	endopeptidase activity
PUP3	proteasome core complex, beta-subunit complex	ubiquitin-dependent protein catabolic process	endopeptidase activity
RGR1	nucleus mediator complex	transcription from RNA polymerase II promoter	RNA polymerase II transcription mediator activity
RPN10	proteasome regulatory particle, base subcomplex proteasome complex	ubiquitin-dependent protein catabolic process	endopeptidase activity
RPN11	nucleus proteasome regulatory particle, lid subcomplex	ubiquitin-dependent protein catabolic process	endopeptidase activity
RPN12	proteasome regulatory particle, lid subcomplex	ubiquitin-dependent protein catabolic process	endopeptidase activity
RPN13	proteasome regulatory particle, lid subcomplex	proteolysis	endopeptidase activity
RPN3	proteasome regulatory particle, lid subcomplex	ubiquitin-dependent protein catabolic process	molecular_function
RPN5	proteasome regulatory particle, lid subcomplex	ubiquitin-dependent protein catabolic process	molecular_function
RPN6	proteasome regulatory particle, lid subcomplex	ubiquitin-dependent protein catabolic process	structural molecule activity
RPN7	proteasome regulatory particle, lid subcomplex	ubiquitin-dependent protein catabolic process	structural molecule activity
RPN8	proteasome regulatory particle, lid subcomplex	ubiquitin-dependent protein catabolic process	molecular_function
RPN9	proteasome regulatory particle, lid subcomplex	ubiquitin-dependent protein catabolic process	structural molecule activity
RPT1	proteasome regulatory particle, base subcomplex	ubiquitin-dependent protein catabolic process	ATPase activity endopeptidase activity
RPT2	nucleus proteasome regulatory particle, base subcomplex	ubiquitin-dependent protein catabolic process	ATPase activity endopeptidase activity
RPT3	proteasome regulatory particle, base subcomplex	ubiquitin-dependent protein catabolic process	ATPase activity endopeptidase activity
RPT4	nucleus proteasome regulatory particle, base subcomplex	ubiquitin-dependent protein catabolic process	ATPase activity endopeptidase activity
RPT5	proteasome regulatory particle, base subcomplex	ubiquitin-dependent protein catabolic process	ATPase activity endopeptidase activity
RPT6	nucleus proteasome regulatory particle, base subcomplex	ubiquitin-dependent protein catabolic process	ATPase activity endopeptidase activity
SCL1	mitochondrion proteasome core complex, alpha-subunit complex	ubiquitin-dependent protein catabolic process	endopeptidase activity
UBP6	proteasome regulatory particle	protein deubiquitination	ubiquitin-specific protease activity
YFL006W

Cellular Component Analysis

Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
proteasome complex	2.4163E-66	36	48	31	6292
proteasome accessory complex	8.1669E-36	36	23	17	6292
proteasome regulatory particle	8.1669E-36	36	23	17	6292
proteasome core complex	3.3337E-28	36	16	13	6292
proteasome regulatory particle, lid subcomplex	2.2144E-20	36	10	9	6292
protein complex	3.2374E-20	36	1137	32	6292
macromolecular complex	1.1563E-16	36	1635	33	6292
proteasome regulatory particle, base subcomplex	3.8611E-15	36	9	7	6292
proteasome core complex, alpha-subunit complex	1.5794E-13	36	7	6	6292
proteasome core complex, beta-subunit complex	1.5794E-13	36	7	6	6292
intracellular part	1.732E-3	36	4938	35	6292
intracellular	2.1969E-3	36	4975	35	6292

Biological Process Analysis

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
protein catabolic process	5.5258E-39	36	189	29	6292
modification-dependent protein catabolic process	3.3803E-37	36	156	27	6292
ubiquitin-dependent protein catabolic process	3.3803E-37	36	156	27	6292
proteolysis involved in cellular protein catabolic process	5.9058E-37	36	159	27	6292
proteolysis	6.4765E-37	36	188	28	6292
modification-dependent macromolecule catabolic process	1.4593E-36	36	164	27	6292
cellular protein catabolic process	4.9268E-36	36	171	27	6292
macromolecule catabolic process	4.166E-33	36	294	29	6292
cellular macromolecule catabolic process	1.3093E-30	36	265	27	6292
catabolic process	4.3345E-28	36	496	30	6292
cellular catabolic process	3.1762E-25	36	415	27	6292
protein metabolic process	9.4681E-19	36	1136	31	6292
cellular protein metabolic process	1.7547E-15	36	1074	28	6292
macromolecule metabolic process	6.2868E-13	36	2349	34	6292
primary metabolic process	2.8698E-11	36	2896	35	6292
metabolic process	5.5465E-10	36	3157	35	6292
cellular macromolecule metabolic process	8.9608E-10	36	2285	31	6292
cellular metabolic process	3.2153E-7	36	3033	32	6292
cellular process	2.0511E-3	36	4426	33	6292

Molecular Function Analysis

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
endopeptidase activity	8.6166E-39	36	54	22	6292
peptidase activity, acting on L-amino acid peptides	1.4917E-34	36	95	23	6292
peptidase activity	6.0412E-27	36	192	23	6292
hydrolase activity	1.2048E-12	36	911	24	6292
catalytic activity	1.5934E-5	36	2150	25	6292
ATPase activity	1.573E-4	36	211	7	6292
nucleoside-triphosphatase activity	2.2482E-3	36	329	7	6292
hydrolase activity, acting on acid anhydrides	3.3473E-3	36	353	7	6292
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	3.3473E-3	36	353	7	6292
pyrophosphatase activity	3.3473E-3	36	353	7	6292

View Protein Complex Details

Complex Overview

Complex Member Proteins

Cellular Component Analysis

Biological Process Analysis

Molecular Function Analysis