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View Protein Complex Details

Complex Overview

From Publication: Krogan N. J. et al. (2006) Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature. 2006 Mar 30;440(7084):637-43. Epub 2006 Mar 22.
Notes: From the published set of core protein complex predictions.
Complex Size: 12 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
CAK1
  • cytoplasm
  • G2/M transition of mitotic cell cycle
  • G1 phase of mitotic cell cycle
  • protein amino acid phosphorylation
  • meiosis
  • cyclin-dependent protein kinase activating kinase activity
  • CDC34
  • nucleus
  • cytoplasm
  • SCF ubiquitin ligase complex
  • G2/M transition of mitotic cell cycle
  • protein polyubiquitination
  • G1/S transition of mitotic cell cycle
  • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
  • protein ubiquitination during ubiquitin-dependent protein catabolic process
  • protein autoubiquitination
  • ubiquitin-protein ligase activity
  • CDC53
  • SCF ubiquitin ligase complex
  • G2/M transition of mitotic cell cycle
  • G1/S transition of mitotic cell cycle
  • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
  • protein ubiquitination during ubiquitin-dependent protein catabolic process
  • DNA replication origin binding
  • ubiquitin-protein ligase activity
  • protein binding, bridging
  • CDC9
  • replication fork
  • nucleus
  • mitochondrion
  • lagging strand elongation
  • base-excision repair
  • DNA ligation
  • DNA recombination
  • nucleotide-excision repair
  • DNA ligase (ATP) activity
  • CRT10
  • cellular_component
  • regulation of transcription from RNA polymerase II promoter, global
  • response to DNA damage stimulus
  • molecular_function
  • GRR1
  • nucleus
  • cellular bud neck contractile ring
  • nuclear ubiquitin ligase complex
  • cytoplasm
  • SCF ubiquitin ligase complex
  • G1/S transition of mitotic cell cycle
  • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
  • response to DNA damage stimulus
  • cell cycle arrest in response to pheromone
  • protein ubiquitination
  • ubiquitin-protein ligase activity
  • protein binding
  • MEP3
  • plasma membrane
  • ammonium transport
  • nitrogen utilization
  • ammonium transmembrane transporter activity
  • MET30
  • nucleus
  • SCF ubiquitin ligase complex
  • nuclear SCF ubiquitin ligase complex
  • response to arsenic
  • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
  • response to cadmium ion
  • cell cycle
  • protein ubiquitination
  • protein binding
  • MMS1
  • cellular_component
  • DNA repair
  • negative regulation of transposition, DNA-mediated
  • molecular_function
  • POR1
  • integral to mitochondrial outer membrane
  • mitochondrion
  • mitochondrial outer membrane
  • ion transport
  • aerobic respiration
  • mitochondrion organization
  • voltage-gated anion channel activity
  • RTT101
  • nucleus
  • cytoplasm
  • regulation of mitosis
  • negative regulation of transposition, DNA-mediated
  • ubiquitin-dependent protein catabolic process
  • ubiquitin-protein ligase activity
  • protein binding
  • SAF1
  • cellular_component
  • proteasomal ubiquitin-dependent protein catabolic process
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    SCF ubiquitin ligase complex 2.486E-9 12 11 4 6292
    cullin-RING ubiquitin ligase complex 7.5177E-9 12 14 4 6292
    ubiquitin ligase complex 8.9981E-7 12 43 4 6292
    nuclear ubiquitin ligase complex 8.2512E-4 12 23 2 6292
    nuclear SCF ubiquitin ligase complex 3.811E-3 12 2 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    SCF-dependent proteasomal ubiquitin-dependent protein catabolic process 2.6474E-10 12 7 4 6292
    proteasomal protein catabolic process 1.022E-7 12 69 5 6292
    proteasomal ubiquitin-dependent protein catabolic process 1.022E-7 12 69 5 6292
    modification-dependent protein catabolic process 1.7245E-7 12 156 6 6292
    ubiquitin-dependent protein catabolic process 1.7245E-7 12 156 6 6292
    proteolysis involved in cellular protein catabolic process 1.932E-7 12 159 6 6292
    modification-dependent macromolecule catabolic process 2.3236E-7 12 164 6 6292
    cellular protein catabolic process 2.9799E-7 12 171 6 6292
    proteolysis 5.2301E-7 12 188 6 6292
    protein catabolic process 5.3971E-7 12 189 6 6292
    cellular macromolecule catabolic process 3.9369E-6 12 265 6 6292
    protein ubiquitination 4.8266E-6 12 65 4 6292
    macromolecule catabolic process 7.2038E-6 12 294 6 6292
    protein modification by small protein conjugation 1.4816E-5 12 86 4 6292
    G2/M transition of mitotic cell cycle 1.8839E-5 12 29 3 6292
    interphase of mitotic cell cycle 2.3903E-5 12 97 4 6292
    interphase 2.3903E-5 12 97 4 6292
    protein modification by small protein conjugation or removal 4.5238E-5 12 114 4 6292
    cellular catabolic process 5.2166E-5 12 415 6 6292
    mitotic cell cycle 6.5896E-5 12 255 5 6292
    regulation of transposition, DNA-mediated 9.2781E-5 12 8 2 6292
    negative regulation of transposition, DNA-mediated 9.2781E-5 12 8 2 6292
    transposition, DNA-mediated 9.2781E-5 12 8 2 6292
    G1/S transition of mitotic cell cycle 9.8792E-5 12 50 3 6292
    negative regulation of transposition 1.1916E-4 12 9 2 6292
    regulation of transposition 1.1916E-4 12 9 2 6292
    catabolic process 1.426E-4 12 496 6 6292
    protein ubiquitination during ubiquitin-dependent protein catabolic process 1.8167E-4 12 11 2 6292
    cell cycle 1.9586E-4 12 525 6 6292
    negative regulation of DNA recombination 2.1777E-4 12 12 2 6292
    post-translational protein modification 3.2502E-4 12 357 5 6292
    regulation of DNA recombination 3.4536E-4 12 15 2 6292
    cell cycle phase 4.1416E-4 12 376 5 6292
    negative regulation of DNA metabolic process 6.8633E-4 12 21 2 6292
    response to DNA damage stimulus 7.5292E-4 12 236 4 6292
    DNA recombination 1.1312E-3 12 114 3 6292
    cellular macromolecule metabolic process 1.1724E-3 12 2285 10 6292
    cell cycle process 1.402E-3 12 490 5 6292
    cellular protein metabolic process 1.4792E-3 12 1074 7 6292
    regulation of DNA metabolic process 1.5037E-3 12 31 2 6292
    macromolecule metabolic process 1.504E-3 12 2349 10 6292
    protein modification process 1.5226E-3 12 499 5 6292
    cellular response to stress 1.6305E-3 12 290 4 6292
    DNA ligation 1.9072E-3 12 1 1 6292
    protein autoubiquitination 1.9072E-3 12 1 1 6292
    protein metabolic process 2.0859E-3 12 1136 7 6292
    cellular metabolic process 2.1697E-3 12 3033 11 6292
    macromolecule modification 2.7467E-3 12 569 5 6292
    metabolic process 3.2647E-3 12 3157 11 6292
    regulation of transcription from RNA polymerase II promoter, global 3.811E-3 12 2 1 6292
    cellular response to stimulus 4.3541E-3 12 379 4 6292
    response to cadmium ion 9.5026E-3 12 5 1 6292
    primary metabolic process 9.5102E-3 12 2896 10 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ubiquitin-protein ligase activity 2.8392E-6 12 57 4 6292
    small conjugating protein ligase activity 3.9891E-6 12 62 4 6292
    ligase activity 4.9861E-6 12 150 5 6292
    acid-amino acid ligase activity 6.8843E-6 12 71 4 6292
    ligase activity, forming carbon-nitrogen bonds 2.1103E-5 12 94 4 6292
    cyclin-dependent protein kinase activating kinase activity 3.811E-3 12 2 1 6292
    DNA ligase activity 3.811E-3 12 2 1 6292
    DNA ligase (ATP) activity 3.811E-3 12 2 1 6292
    voltage-gated anion channel activity 5.7116E-3 12 3 1 6292
    anion channel activity 5.7116E-3 12 3 1 6292
    ligase activity, forming phosphoric ester bonds 7.6087E-3 12 4 1 6292

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