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Catalysis of the ligation of two substances via a phosphoric ester bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. Catalysis of the formation of a phosphodiester bond between the 3'-hydroxyl group at the end of one DNA chain and the 5'-phosphate group at the end of another; requires an energy source such as ATP or NAD+. Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m).

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: DNA ligase (ATP) activity
Acc: GO:0003910
Aspect: Molecular Function
Desc: Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m).
Synonyms:
  • deoxyribonucleic repair enzyme
  • deoxyribonucleic acid ligase
  • deoxyribonucleic acid repair enzyme
  • deoxyribonucleic joinase
  • deoxyribonucleic ligase
  • deoxyribonucleic-joining enzyme
  • DNA-joining enzyme
  • deoxyribonucleate ligase
  • deoxyribonucleic acid joinase
  • DNA joinase activity
  • polynucleotide ligase (ATP) activity
  • polydeoxyribonucleotide synthase (ATP) activity
  • DNA repair enzyme activity
  • polynucleotide ligase
  • poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming)
  • deoxyribonucleic acid-joining enzyme
  • sealase activity
Proteins in PDR annotated with:
   This term: 42 [Search]
   Term or descendants: 42 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0003910 - DNA ligase (ATP) activity (interactive image map)
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