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View Protein Complex Details

Complex Overview

From Publication: Krogan N. J. et al. (2006) Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature. 2006 Mar 30;440(7084):637-43. Epub 2006 Mar 22.
Notes: From the published set of core protein complex predictions.
Complex Size: 33 proteins

Complex Member Proteins

Protein

 GO Cellular Component GO Biological Process GO Molecular Function
ACK1
  • mitochondrion
    		•
  • biological_process
    		•
  • molecular_function
    		•
    CIN8
  • spindle microtubule
  • mitochondrion
  • condensed nuclear chromosome kinetochore
  • kinesin complex
    		•
  • mitotic sister chromatid segregation
  • mitotic anaphase B
  • mitotic spindle organization in nucleus
    		•
  • microtubule motor activity
    		•
    DCG1
  • cellular_component
    		•
  • nitrogen compound metabolic process
    		•
  • molecular_function
    		•
    GNA1
  • nucleus
  • cytoplasm
    		•
  • UDP-N-acetylglucosamine biosynthetic process
    		•
  • glucosamine 6-phosphate N-acetyltransferase activity
    		•
    MCM6
  • nucleus
  • pre-replicative complex
  • cytoplasm
  • MCM complex
    		•
  • DNA replication initiation
  • DNA unwinding involved in replication
    		•
  • chromatin binding
  • ATP-dependent DNA helicase activity
    		•
    MLP1
  • nuclear envelope
  • ribonucleoprotein complex
  • nucleoplasm
    		•
  • mRNA export from nucleus
  • protein import into nucleus
  • regulation of transcription
    		•
  • ribonucleoprotein binding
    		•
    PMD1
  • cytoplasm
    		•
  • sporulation resulting in formation of a cellular spore
    		•
  • molecular_function
    		•
    PMT4
  • endoplasmic reticulum
    		•
  • protein amino acid O-linked glycosylation
    		•
  • dolichyl-phosphate-mannose-protein mannosyltransferase activity
    		•
    PRE1
  • nucleus
  • proteasome core complex, beta-subunit complex
    		•
  • ascospore formation
  • response to stress
  • ubiquitin-dependent protein catabolic process
    		•
  • endopeptidase activity
    		•
    PRE10
  • proteasome core complex, alpha-subunit complex
    		•
  • ubiquitin-dependent protein catabolic process
    		•
  • endopeptidase activity
    		•
    PRE2
  • proteasome core complex, beta-subunit complex
    		•
  • ubiquitin-dependent protein catabolic process
    		•
  • endopeptidase activity
    		•
    PRE3
  • proteasome core complex, beta-subunit complex
    		•
  • ascospore formation
  • response to stress
  • ubiquitin-dependent protein catabolic process
    		•
  • endopeptidase activity
    		•
    PRE4
  • proteasome core complex, beta-subunit complex
    		•
  • ubiquitin-dependent protein catabolic process
    		•
  • endopeptidase activity
    		•
    PRE5
  • proteasome core complex, alpha-subunit complex
    		•
  • ubiquitin-dependent protein catabolic process
    		•
  • endopeptidase activity
    		•
    PRE6
  • mitochondrion
  • proteasome core complex, alpha-subunit complex
  • cytosol
    		•
  • ubiquitin-dependent protein catabolic process
    		•
  • endopeptidase activity
    		•
    PRE7
  • proteasome core complex, beta-subunit complex
    		•
  • ubiquitin-dependent protein catabolic process
    		•
  • endopeptidase activity
    		•
    PRE8
  • proteasome core complex, alpha-subunit complex
    		•
  • ubiquitin-dependent protein catabolic process
    		•
  • endopeptidase activity
    		•
    PRE9
  • proteasome core complex, alpha-subunit complex
    		•
  • filamentous growth
  • ubiquitin-dependent protein catabolic process
    		•
  • endopeptidase activity
    		•
    PUP1
  • proteasome core complex, beta-subunit complex
    		•
  • ubiquitin-dependent protein catabolic process
    		•
  • endopeptidase activity
    		•
    PUP2
  • proteasome core complex, alpha-subunit complex
    		•
  • ascospore formation
  • response to stress
  • ubiquitin-dependent protein catabolic process
    		•
  • endopeptidase activity
    		•
    PUP3
  • proteasome core complex, beta-subunit complex
    		•
  • ubiquitin-dependent protein catabolic process
    		•
  • endopeptidase activity
    		•
    RFT1
  • endoplasmic reticulum membrane
    		•
  • oligosaccharide transport
  • protein amino acid N-linked glycosylation
    		•
  • oligosaccharide transmembrane transporter activity
    		•
    SCL1
  • mitochondrion
  • proteasome core complex, alpha-subunit complex
    		•
  • ubiquitin-dependent protein catabolic process
    		•
  • endopeptidase activity
    		•
    SGA1
  • fungal-type vacuole
    		•
  • ascospore formation
  • glycogen catabolic process
    		•
  • glucan 1,4-alpha-glucosidase activity
    		•
    SNQ2
  • mitochondrion
  • plasma membrane
    		•
  • response to drug
  • response to singlet oxygen
    		•
  • xenobiotic-transporting ATPase activity
    		•
    TOS8
  • nucleus
    		•
  • regulation of transcription involved in G1/S-phase of mitotic cell cycle
    		•
  • transcription factor activity
    		•
    UMP1
  • nucleus
  • cytoplasm
    		•
  • response to DNA damage stimulus
  • proteasome assembly
  • ubiquitin-dependent protein catabolic process
    		•
  • molecular_function
    		•
    YCR076C
  • cellular_component
    		•
  • biological_process
    		•
  • molecular_function
    		•
    YDR179W-A
  • cellular_component
    		•
  • biological_process
    		•
  • molecular_function
    		•
    YJL132W
  • membrane fraction
    		•
  • biological_process
    		•
  • molecular_function
    		•
    YKR070W
  • mitochondrion
    		•
  • biological_process
    		•
  • molecular_function
    		•
    YLR211C
  • cytoplasm
    		•
  • biological_process
    		•
  • molecular_function
    		•
    YLR290C
  • mitochondrion
    		•
  • biological_process
    		•
  • molecular_function
    		•

    Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    proteasome core complex 5.6697E-32 33 16 14 6292
    proteasome complex 2.0812E-22 33 48 14 6292
    proteasome core complex, alpha-subunit complex 5.5334E-17 33 7 7 6292
    proteasome core complex, beta-subunit complex 5.5334E-17 33 7 7 6292
    protein complex 6.1582E-5 33 1137 16 6292
    macromolecular complex 1.473E-3 33 1635 17 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    modification-dependent protein catabolic process 2.9502E-16 33 156 15 6292
    ubiquitin-dependent protein catabolic process 2.9502E-16 33 156 15 6292
    proteolysis involved in cellular protein catabolic process 3.9467E-16 33 159 15 6292
    modification-dependent macromolecule catabolic process 6.3281E-16 33 164 15 6292
    cellular protein catabolic process 1.1948E-15 33 171 15 6292
    proteolysis 5.0104E-15 33 188 15 6292
    protein catabolic process 5.4273E-15 33 189 15 6292
    macromolecule catabolic process 1.9651E-13 33 294 16 6292
    cellular macromolecule catabolic process 8.264E-13 33 265 15 6292
    cellular catabolic process 5.2446E-10 33 415 15 6292
    catabolic process 5.8243E-10 33 496 16 6292
    cellular protein metabolic process 5.8834E-6 33 1074 17 6292
    protein metabolic process 1.2893E-5 33 1136 17 6292
    sporulation 4.3394E-4 33 125 5 6292
    sporulation resulting in formation of a cellular spore 4.3394E-4 33 125 5 6292
    anatomical structure formation involved in morphogenesis 5.0171E-4 33 129 5 6292
    cell differentiation 9.3855E-4 33 148 5 6292
    cellular macromolecule metabolic process 1.2624E-3 33 2285 21 6292
    macromolecule metabolic process 1.8962E-3 33 2349 21 6292
    sexual sporulation 2.6149E-3 33 112 4 6292
    sexual sporulation resulting in formation of a cellular spore 2.6149E-3 33 112 4 6292
    cell development 2.6149E-3 33 112 4 6292
    ascospore formation 2.6149E-3 33 112 4 6292
    reproductive process in single-celled organism 4.9856E-3 33 134 4 6292
    reproductive developmental process 7.5906E-3 33 151 4 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    endopeptidase activity 1.3767E-21 33 54 14 6292
    peptidase activity, acting on L-amino acid peptides 7.7136E-18 33 95 14 6292
    peptidase activity 1.864E-13 33 192 14 6292
    hydrolase activity 8.0313E-8 33 911 18 6292
    catalytic activity 1.652E-3 33 2150 20 6292
    oligosaccharide transmembrane transporter activity 5.2448E-3 33 1 1 6292
    glucosamine 6-phosphate N-acetyltransferase activity 5.2448E-3 33 1 1 6292
    glucan 1,4-alpha-glucosidase activity 5.2448E-3 33 1 1 6292
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle