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View Protein Complex Details

Complex Overview

From Publication: Mewes, H. W. et al. MIPS: Analysis and annotation of proteins from whole genomes. Nucleic Acids Res. 32, D41-D44
Notes: MIPS hand-curated complex set. MIPS complex ID: 440.30.20
Complex Size: 24 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
DRS1
  • nuclear outer membrane
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • ATP-dependent RNA helicase activity
  • GAR1
  • box H/ACA snoRNP complex
  • nuclear outer membrane
  • nucleolus
  • small nucleolar ribonucleoprotein complex
  • ribosome biogenesis
  • RNA binding
  • IFH1
  • nucleus
  • nucleolus
  • transcription from RNA polymerase III promoter
  • transcription from RNA polymerase II promoter
  • chromatin silencing at telomere
  • transcription factor activity
  • specific RNA polymerase II transcription factor activity
  • NOP1
  • nuclear outer membrane
  • nucleolus
  • ribosome
  • small nucleolar ribonucleoprotein complex
  • rRNA modification
  • RNA methylation
  • maturation of SSU-rRNA
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • snoRNA 3'-end processing
  • methyltransferase activity
  • NPL3
  • nucleus
  • cytoplasm
  • mRNA export from nucleus
  • pseudohyphal growth
  • poly(A) RNA binding
  • mRNA binding
  • NSR1
  • nucleus
  • mitochondrion
  • nucleolus
  • telomere maintenance
  • ribosomal small subunit assembly
  • rRNA processing
  • RNA binding
  • single-stranded DNA binding
  • POP1
  • ribonuclease MRP complex
  • nucleolar ribonuclease P complex
  • tRNA processing
  • rRNA processing
  • mRNA cleavage
  • ribonuclease P activity
  • ribonuclease MRP activity
  • POP2
  • cytoplasm
  • CCR4-NOT core complex
  • nuclear-transcribed mRNA poly(A) tail shortening
  • regulation of transcription from RNA polymerase II promoter
  • RNA elongation from RNA polymerase II promoter
  • 3'-5'-exoribonuclease activity
  • RAT1
  • nucleus
  • mitochondrion
  • nuclear outer membrane
  • termination of RNA polymerase II transcription, poly(A)-coupled
  • RNA processing
  • 5'-3' exoribonuclease activity
  • RNT1
  • nuclear outer membrane
  • nucleolus
  • nucleoplasm
  • ribosome biogenesis
  • ribonuclease III activity
  • RRP3
  • nuclear outer membrane
  • nucleolus
  • ribosome biogenesis
  • ATP-dependent RNA helicase activity
  • SBP1
  • nuclear outer membrane
  • nucleolus
  • negative regulation of translation in response to stress
  • response to stress
  • snoRNA binding
  • SNM1
  • ribonuclease MRP complex
  • rRNA processing
  • mRNA cleavage
  • RNA binding
  • ribonuclease MRP activity
  • SRD1
  • nucleus
  • cytoplasm
  • rRNA processing
  • molecular_function
  • UTP10
  • mitochondrion
  • small nucleolar ribonucleoprotein complex
  • maturation of SSU-rRNA
  • ribosome biogenesis
  • snoRNA binding
  • UTP11
  • small nucleolar ribonucleoprotein complex
  • maturation of SSU-rRNA
  • ribosome biogenesis
  • snoRNA binding
  • UTP13
  • small nucleolar ribonucleoprotein complex
  • maturation of SSU-rRNA
  • snoRNA binding
  • UTP4
  • small nucleolar ribonucleoprotein complex
  • maturation of SSU-rRNA
  • ribosome biogenesis
  • snoRNA binding
  • UTP5
  • small nucleolar ribonucleoprotein complex
  • maturation of SSU-rRNA
  • ribosome biogenesis
  • snoRNA binding
  • UTP6
  • small nucleolar ribonucleoprotein complex
  • maturation of SSU-rRNA
  • ribosome biogenesis
  • snoRNA binding
  • UTP7
  • nuclear outer membrane
  • small nucleolar ribonucleoprotein complex
  • ribosome biogenesis
  • rRNA processing
  • snoRNA binding
  • UTP8
  • small nucleolar ribonucleoprotein complex
  • maturation of SSU-rRNA
  • ribosome biogenesis
  • snoRNA binding
  • UTP9
  • nucleus
  • nucleolus
  • small nucleolar ribonucleoprotein complex
  • maturation of SSU-rRNA
  • ribosome biogenesis
  • snoRNA binding
  • YME2
  • mitochondrion
  • mitochondrial inner membrane
  • rRNA processing
  • mitochondrial genome maintenance
  • exonuclease activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    small nucleolar ribonucleoprotein complex 4.183E-20 24 72 13 6292
    nuclear outer membrane 5.3875E-10 24 86 8 6292
    nuclear membrane 1.4309E-9 24 97 8 6292
    nucleolus 1.8932E-9 24 211 10 6292
    ribonucleoprotein complex 6.7183E-9 24 514 13 6292
    outer membrane 1.7512E-7 24 178 8 6292
    organelle outer membrane 1.7512E-7 24 178 8 6292
    nuclear lumen 2.5275E-7 24 453 11 6292
    nuclear envelope 4.1411E-7 24 199 8 6292
    nuclear membrane-endoplasmic reticulum network 1.3361E-6 24 232 8 6292
    organelle lumen 1.08E-5 24 660 11 6292
    intracellular organelle lumen 1.08E-5 24 660 11 6292
    membrane-enclosed lumen 1.9073E-5 24 700 11 6292
    nuclear part 5.0758E-5 24 1103 13 6292
    envelope 5.6305E-5 24 505 9 6292
    organelle envelope 5.6305E-5 24 505 9 6292
    endomembrane system 7.1464E-5 24 398 8 6292
    ribonuclease MRP complex 6.1594E-4 24 10 2 6292
    organelle membrane 6.3461E-4 24 692 9 6292
    macromolecular complex 7.7987E-4 24 1635 14 6292
    non-membrane-bounded organelle 1.6426E-3 24 959 10 6292
    intracellular non-membrane-bounded organelle 1.6426E-3 24 959 10 6292
    membrane part 2.2838E-3 24 662 8 6292
    nucleus 2.346E-3 24 2041 15 6292
    intracellular part 2.9448E-3 24 4938 24 6292
    intracellular 3.5241E-3 24 4975 24 6292
    box H/ACA snoRNP complex 7.6148E-3 24 2 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    rRNA processing 2.0556E-20 24 128 15 6292
    ribosome biogenesis 2.3815E-20 24 346 19 6292
    rRNA metabolic process 5.9637E-20 24 137 15 6292
    ribonucleoprotein complex biogenesis 1.0614E-19 24 374 19 6292
    ncRNA processing 6.2067E-17 24 215 15 6292
    RNA processing 3.1405E-16 24 380 17 6292
    ncRNA metabolic process 9.2491E-16 24 257 15 6292
    cellular component biogenesis 1.2795E-14 24 694 19 6292
    maturation of SSU-rRNA 3.4828E-13 24 59 9 6292
    RNA metabolic process 8.4426E-11 24 954 18 6292
    gene expression 1.0011E-9 24 1283 19 6292
    nucleic acid metabolic process 6.4802E-8 24 1415 18 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 3.41E-7 24 1566 18 6292
    cellular nitrogen compound metabolic process 2.4472E-6 24 1770 18 6292
    nitrogen compound metabolic process 2.9521E-6 24 1791 18 6292
    cellular macromolecule metabolic process 2.1855E-5 24 2285 19 6292
    macromolecule metabolic process 3.4384E-5 24 2349 19 6292
    cellular process 2.1149E-4 24 4426 24 6292
    primary metabolic process 9.4559E-4 24 2896 19 6292
    ribosomal subunit assembly 1.1234E-3 24 55 3 6292
    ribosome assembly 1.7443E-3 24 64 3 6292
    cellular metabolic process 1.8975E-3 24 3033 19 6292
    organelle assembly 2.1663E-3 24 69 3 6292
    metabolic process 3.426E-3 24 3157 19 6292
    negative regulation of translation in response to stress 3.8144E-3 24 1 1 6292
    regulation of translation in response to stress 3.8144E-3 24 1 1 6292
    mRNA cleavage 3.9653E-3 24 25 2 6292
    ribonucleoprotein complex assembly 4.9022E-3 24 92 3 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    snoRNA binding 3.1327E-18 24 31 10 6292
    RNA binding 4.7651E-12 24 367 14 6292
    nucleic acid binding 1.0609E-9 24 666 15 6292
    binding 9.1202E-6 24 1294 15 6292
    nuclease activity 7.7575E-5 24 199 6 6292
    ribonuclease activity 2.0572E-4 24 149 5 6292
    ribonuclease MRP activity 6.1594E-4 24 10 2 6292
    exonuclease activity 6.648E-4 24 46 3 6292
    hydrolase activity, acting on ester bonds 1.4192E-3 24 341 6 6292
    endoribonuclease activity, producing 5'-phosphomonoesters 2.0555E-3 24 18 2 6292
    endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 3.3597E-3 24 23 2 6292
    ribonuclease III activity 3.8144E-3 24 1 1 6292
    exoribonuclease activity, producing 5'-phosphomonoesters 4.2858E-3 24 26 2 6292
    exoribonuclease activity 4.2858E-3 24 26 2 6292
    endoribonuclease activity 4.6179E-3 24 27 2 6292
    ATP-dependent RNA helicase activity 4.9616E-3 24 28 2 6292
    RNA-dependent ATPase activity 5.3167E-3 24 29 2 6292
    exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 7.2617E-3 24 34 2 6292
    5'-3' exoribonuclease activity 7.6148E-3 24 2 1 6292

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