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Protein Overview: IMD2

General Information:
Name(s) found: IMD2 / YHR216W [SGD]
Description(s) found:
Found 23 descriptions.
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  • Inosine monophosphate dehydrogenase, catalyzes the rate-limiting step in GTP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitatio [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 523 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: GTP biosynthetic process [TASLink to PubMed article]
    Molecular Function: IMP dehydrogenase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAIRDYKTA LDFTKSLPRP DGLSVQELMD SKIRGGLTYN DFLILPGLVD FASSEVSLQT  60
   61 KLTRNITLNI PLVSSPMDTV TESEMATFMA LLGGIGFIHH NCTPEDQADM VRRVKNYENG 120
  121 FINNPIVISP TTTVGEAKSM KEKYGFAGFP VTTDGKRNAK LVGVITSRDI QFVEDNSLLV 180
  181 QDVMTKNPVT GAQGITLSEG NEILKKIKKG RLLVVDEKGN LVSMLSRTDL MKNQNYPLAS 240
  241 KSANTKQLLC GASIGTMDAD KERLRLLVKA GLDVVILDSS QGNSIFELNM LKWVKESFPG 300
  301 LEVIAGNVVT REQAANLIAA GADGLRIGMG TGSICITQEV MACGRPQGTA VYNVCEFANQ 360
  361 FGVPCMADGG VQNIGHITKA LALGSSTVMM GGMLAGTTES PGEYFYQDGK RLKAYRGMGS 420
  421 IDAMQKTGTK GNASTSRYFS ESDSVLVAQG VSGAVVDKGS IKKFIPYLYN GLQHSCQDIG 480
  481 CRSLTLLKNN VQRGKVRFEF RTASAQLEGG VHNLHSYEKR LHN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) IMD1 IMD2 IMD3 IMD4 RPL13B YAR075W
    View Details Krogan NJ, et al. (2006) COX18 IMD1 IMD2 IMD3 IMD4 PDE2 YAR075W
    View Details Gavin AC, et al. (2006) IMD2 LYS2 SXM1
    View Details Ho Y, et al. (2002) AAC3 AI1 AIM46 ARE1 BUD32 CAR2 CDC33 CIC1 CKA1 CKA2 CKB1 CPR6 CRM1 DBP7 DIA4 DRS1 EBP2 FET4 FUN12 GRS1 GRX3 GRX4 HAS1 HEF3 HHO1 IDP2 IMD2 IMD3 IMD4 KAE1 KRE33 KRI1 MAG1 MAG2 MGM101 MPH1 MSC3 MSH2 NOC2 NOP1 NOP12 NOP13 NOP4 NOP7 NPA3 NPL3 OYE2 PDC6 PHO81 PUF6 RET1 RNH202 RPC82 RPF2 RPN1 RPN5 RPN6 RPT1 RRP12 RRP5 SAH1 SEC18 SEC23 SGO1 SPT2 TIF4631 TIF4632 TMA29 URA7 UTP22 YHR033W

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run PSF2 No Comments Hazbun TR, et al. (2003)
    View Run HSL7 No Comments McCusker D, et al (2007)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run MIH1 control 1 McCusker D, et al (2007)
    View Run MIH1 control 2 McCusker D, et al (2007)
    View Run MIH1 experimental1 - mih1-1 McCusker D, et al (2007)
    View Run MIH1 experimental2 - mih1-2 McCusker D, et al (2007)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run BOI1 Sample boi 1 with ha tag from october 2005 McCusker D, et al (2007)
    View Run BOI1 Sample boi1 with gst from october 2005 McCusker D, et al (2007)
    View Run BOI1 Sample bob1 (2nd set) from october 2005 McCusker D, et al (2007)
    View Run BOI2 Boi 2 gst control McCusker D, et al (2007)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run None Entered #17 Mitotic Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen CLN3 IMD2 2 Unpublished Fields Lab Data
    View Screen NSE4 IMD2 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data IMD2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..523] PSI-BLAST 1947.0 Inosine monophosphate dehydrogenase (IMPDH)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • IMP dehydrogenase activity
    		•  2.02048863053452 bayes_pls_golite062009
  • binding
    		•  0.964202692685807 bayes_pls_golite062009
  • transporter activity
    		•  0.961062314616209 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.807029018941177 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.640881170978843 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.525366315833255 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.440262824681055 bayes_pls_golite062009
  • protein binding
    		•  0.22179604283012 bayes_pls_golite062009
  • catalytic activity
    		•  0.181756622780318 bayes_pls_golite062009
  • di-, tri-valent inorganic cation transmembrane transporter activity
    		•  0.0973526732376297 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.94

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle