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Protein Overview: NUP100

General Information:
Name(s) found: NUP100 / YKL068W [SGD]
Description(s) found:
Found 29 descriptions.
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  • Subunit of the nuclear pore complex (NPC) that is localized to both sides of the pore; contains a repetitive GLFG motif that interacts with mRNA export factor Mex67p and with karyopherin Kap95p; homologous to Nup116p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 959 amino acids

    Gene Ontology:
    Cellular Component: nuclear pore [IDALink to PubMed article]
    Biological Process: mRNA export from nucleus [TASLink to PubMed article]
    rRNA export from nucleus [TASLink to PubMed article]
    nuclear pore organization [TASLink to PubMed article]
    snRNP protein import into nucleus [TASLink to PubMed article]
    mRNA-binding (hnRNP) protein import into nucleus [TASLink to PubMed article]
    snRNA export from nucleus [TASLink to PubMed article]
    tRNA export from nucleus [TASLink to PubMed article]
    NLS-bearing substrate import into nucleus [TASLink to PubMed article]
    protein export from nucleus [TASLink to PubMed article]
    ribosomal protein import into nucleus [TASLink to PubMed article]
    Molecular Function: structural molecule activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFGNNRPMFG GSNLSFGSNT SSFGGQQSQQ PNSLFGNSNN NNNSTSNNAQ SGFGGFTSAA  60
   61 GSNSNSLFGN NNTQNNGAFG QSMGATQNSP FGSLNSSNAS NGNTFGGSSS MGSFGGNTNN 120
  121 AFNNNSNSTN SPFGFNKPNT GGTLFGSQNN NSAGTSSLFG GQSTSTTGTF GNTGSSFGTG 180
  181 LNGNGSNIFG AGNNSQSNTT GSLFGNQQSS AFGTNNQQGS LFGQQSQNTN NAFGNQNQLG 240
  241 GSSFGSKPVG SGSLFGQSNN TLGNTTNNRN GLFGQMNSSN QGSSNSGLFG QNSMNSSTQG 300
  301 VFGQNNNQMQ INGNNNNSLF GKANTFSNSA SGGLFGQNNQ QQGSGLFGQN SQTSGSSGLF 360
  361 GQNNQKQPNT FTQSNTGIGL FGQNNNQQQQ STGLFGAKPA GTTGSLFGGN SSTQPNSLFG 420
  421 TTNVPTSNTQ SQQGNSLFGA TKLTNMPFGG NPTANQSGSG NSLFGTKPAS TTGSLFGNNT 480
  481 ASTTVPSTNG LFGNNANNST STTNTGLFGA KPDSQSKPAL GGGLFGNSNS NSSTIGQNKP 540
  541 VFGGTTQNTG LFGATGTNSS AVGSTGKLFG QNNNTLNVGT QNVPPVNNTT QNALLGTTAV 600
  601 PSLQQAPVTN EQLFSKISIP NSITNPVKAT TSKVNADMKR NSSLTSAYRL APKPLFAPSS 660
  661 NGDAKFQKWG KTLERSDRGS STSNSITDPE SSYLNSNDLL FDPDRRYLKH LVIKNNKNLN 720
  721 VINHNDDEAS KVKLVTFTTE SASKDDQASS SIAASKLTEK AHSPQTDLKD DHDESTPDPQ 780
  781 SKSPNGSTSI PMIENEKISS KVPGLLSNDV TFFKNNYYIS PSIETLGNKS LIELRKINNL 840
  841 VIGHRNYGKV EFLEPVDLLN TPLDTLCGDL VTFGPKSCSI YENCSIKPEK GEGINVRCRV 900
  901 TLYSCFPIDK ETRKPIKNIT HPLLKRSIAK LKENPVYKFE SYDPVTGTYS YTIDHPVLT

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) GLE2 NOP14 NUP1 NUP100 NUP116 NUP133 NUP157 NUP159 NUP170 NUP188 NUP2 NUP42 POM152
    View Details Qiu et al. (2008) GLE1 GLE2 KAP123 MEX67 NDC1 NIC96 NOP14 NSP1 NUP1 NUP100 NUP116 NUP120 NUP133 NUP145 NUP157 NUP159 NUP170 NUP188 NUP192 NUP2 NUP42 NUP49 NUP53 NUP57 NUP82 NUP84 NUP85 POM152 SEC13 SUS1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen UBC7 NUP100 2 Unpublished Fields Lab Data
    View Screen CLA4 NUP100 2 Unpublished Fields Lab Data
    View Screen MIG2 NUP100 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data NUP100 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..752] MSA 20.175996 View MSA. No confident structure predictions are available.
    2 View Details [753..959] MSA 1.105938 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.86

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle