Protein Overview: MIG2

General Information:
Name(s) found:	MIG2 / YGL209W [SGD]
Description(s) found: Found 26 descriptions. SHOW ALL	Protein containing zinc fingers, involved in repression, along with Mig1p, of SUC2 (invertase) expression by high levels of glucose; binds to Mig1p-binding sites in SUC2 promoter [SGD]
Organism:	Saccharomyces cerevisiae
Length:	382 amino acids
Gene Ontology:
Cellular Component:	nucleus [TAS]
Biological Process:	negative regulation of transcription from RNA polymerase II promoter by glucose [IGI][IMP]
Molecular Function:	sequence-specific DNA binding [IDA] specific transcriptional repressor activity [IGI][IMP]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPKKQTNFPV DNENRPFRCD TCHRGFHRLE HKKRHLRTHT GEKPHHCAFP GCGKSFSRSD  60
   61 ELKRHMRTHT GQSQRRLKKA SVQKQEFLTV SGIPTIASGV MIHQPIPQVL PANMAINVQA 120
  121 VNGGNIIHAP NAVHPMVIPI MAQPAPIHAS AASFQPATSP MPISTYTPVP SQSFTSFQSS 180
  181 IGSIQSNSDV SSIFSNMNVR VNTPRSVPNS PNDGYLHQQH IPQQYQHQTA SPSVAKQQKT 240
  241 FAHSLASALS TLQKRTPVSA PSTTIESPSS PSDSSHTSAS SSAISLPFSN APSQLAVAKE 300
  301 LESVYLDSNR YTTKTRRERA KFEIPEEQEE DTNNSSSGSN EEEHESLDHE SSKSRKKLSG 360
  361 VKLPPVRNLL KQIDVFNGPK RV

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	MLP2	#25 Asynchronous Prep3-TiO2 Flowthrough	Keck JM, et al. (2011)
View Run	MLP2	#26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2	Keck JM, et al. (2011)
View Run	MLP2	#32 Asynchronous Prep-No Phosphopeptide enrichment	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	MIG2	KEG1	2	Unpublished Fields Lab Data
View Screen	MIG2	EDC1	2	Unpublished Fields Lab Data
View Screen	MIG2	MET28	2	Unpublished Fields Lab Data
View Screen	MIG2	NUP100	2	Unpublished Fields Lab Data
View Screen	MIG2	YLR415C	2	Unpublished Fields Lab Data
View Screen	MIG2	RKI1	2	Unpublished Fields Lab Data

Microscopy / Localization Data

New Feature: Upload Your Own Microscopy Data

	PROTEIN(S)	PUBLICATION
View Data	MIG2	Huh WK, et al. (2003)

Protein Structure Data

[What does the above image mean?]
[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..66]	PSI-BLAST	103.927757	Five-finger GLI1
2	View Details	[67..117]	PSI-BLAST	103.927757	Five-finger GLI1
3	View Details	[118..202]	deduced	N/A	No confident structure predictions are available.
4	View Details	[203..255]	PSI-BLAST	128.68867	No description for 1lu6A_ was found.
5	View Details	[256..382]	PSI-BLAST	128.68867	No description for 1lu6A_ was found.

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
transcription regulator activity	4.70988788192472	bayes_pls_golite062009
nucleic acid binding	4.58713908116892	bayes_pls_golite062009
DNA binding	4.56219307357342	bayes_pls_golite062009
transcription factor activity	3.50954949535763	bayes_pls_golite062009
transcription repressor activity	3.27542149084008	bayes_pls_golite062009
RNA polymerase II transcription factor activity	3.22082323675675	bayes_pls_golite062009
binding	3.10743787485868	bayes_pls_golite062009
transcription activator activity	2.19952417915035	bayes_pls_golite062009
chromatin binding	2.18464662431232	bayes_pls_golite062009
specific RNA polymerase II transcription factor activity	1.63161912031789	bayes_pls_golite062009
sequence-specific DNA binding	1.42975942698743	bayes_pls_golite062009
transcription factor binding	1.39608963544799	bayes_pls_golite062009
transcription corepressor activity	1.34049786451995	bayes_pls_golite062009
protein binding	1.00484935878505	bayes_pls_golite062009
structure-specific DNA binding	0.790771220986801	bayes_pls_golite062009
transcription cofactor activity	0.77874411480713	bayes_pls_golite062009
double-stranded DNA binding	0.53991278722671	bayes_pls_golite062009
catalytic activity	0.245893663605433	bayes_pls_golite062009

No functions predicted.

Term	Confidence	Notes
transcription regulator activity	4.70988788192472	bayes_pls_golite062009
nucleic acid binding	4.58713908116892	bayes_pls_golite062009
DNA binding	4.56219307357342	bayes_pls_golite062009
transcription factor activity	3.50954949535763	bayes_pls_golite062009
transcription repressor activity	3.27542149084008	bayes_pls_golite062009
RNA polymerase II transcription factor activity	3.22082323675675	bayes_pls_golite062009
binding	3.10743787485868	bayes_pls_golite062009
transcription activator activity	2.19952417915035	bayes_pls_golite062009
chromatin binding	2.18464662431232	bayes_pls_golite062009
specific RNA polymerase II transcription factor activity	1.63161912031789	bayes_pls_golite062009
sequence-specific DNA binding	1.42975942698743	bayes_pls_golite062009
transcription factor binding	1.39608963544799	bayes_pls_golite062009
transcription corepressor activity	1.34049786451995	bayes_pls_golite062009
protein binding	1.00484935878505	bayes_pls_golite062009
structure-specific DNA binding	0.790771220986801	bayes_pls_golite062009
transcription cofactor activity	0.77874411480713	bayes_pls_golite062009
double-stranded DNA binding	0.53991278722671	bayes_pls_golite062009
catalytic activity	0.245893663605433	bayes_pls_golite062009

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.80

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2